全文获取类型
收费全文 | 1830篇 |
免费 | 89篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 31篇 |
妇产科学 | 16篇 |
基础医学 | 241篇 |
口腔科学 | 29篇 |
临床医学 | 109篇 |
内科学 | 390篇 |
皮肤病学 | 37篇 |
神经病学 | 286篇 |
特种医学 | 58篇 |
外科学 | 258篇 |
综合类 | 9篇 |
预防医学 | 61篇 |
眼科学 | 45篇 |
药学 | 173篇 |
中国医学 | 6篇 |
肿瘤学 | 167篇 |
出版年
2023年 | 5篇 |
2022年 | 19篇 |
2021年 | 30篇 |
2020年 | 20篇 |
2019年 | 31篇 |
2018年 | 35篇 |
2017年 | 24篇 |
2016年 | 35篇 |
2015年 | 43篇 |
2014年 | 62篇 |
2013年 | 74篇 |
2012年 | 128篇 |
2011年 | 152篇 |
2010年 | 63篇 |
2009年 | 59篇 |
2008年 | 104篇 |
2007年 | 122篇 |
2006年 | 113篇 |
2005年 | 130篇 |
2004年 | 141篇 |
2003年 | 107篇 |
2002年 | 114篇 |
2001年 | 21篇 |
2000年 | 13篇 |
1999年 | 28篇 |
1998年 | 17篇 |
1997年 | 21篇 |
1996年 | 30篇 |
1995年 | 17篇 |
1994年 | 22篇 |
1993年 | 18篇 |
1992年 | 11篇 |
1991年 | 16篇 |
1990年 | 10篇 |
1989年 | 18篇 |
1988年 | 11篇 |
1987年 | 8篇 |
1986年 | 7篇 |
1985年 | 8篇 |
1984年 | 5篇 |
1983年 | 5篇 |
1982年 | 6篇 |
1981年 | 3篇 |
1980年 | 4篇 |
1978年 | 6篇 |
1977年 | 3篇 |
1976年 | 2篇 |
1975年 | 3篇 |
1969年 | 2篇 |
1957年 | 1篇 |
排序方式: 共有1933条查询结果,搜索用时 687 毫秒
51.
Hiroji Uemura Futoshi Sano Akira Nomiya Toshihiro Yamamoto Masafumi Nakamura Yasuhide Miyoshi Kenta Miki Kazumi Noguchi Shin Egawa Yukio Homma Yoshinobu Kubota 《World journal of urology》2013,31(5):1123-1128
Purpose
To explore the possibility of targeted biopsy (TBx) using transrectal ultrasound (US) with perflubutane microbubbles, we studied the findings of different cancerous tissue imaging modalities and evaluated needle biopsy in prostate cancer (PCa) using contrast-enhanced US (CEUS) in a multicenter clinical trial.Methods
Seventy-one patients undergoing prostate biopsy received intravenous injection of perflubutane microbubbles (Sonazoid®). We evaluated and compared images obtained by CEUS. The safety observation period was 2 days after contrast administration.Results
Among the 30 patients with cancer, one or more sites with findings suggestive of cancer in CEUS were detected in 23 patients (32.4%) by TBx. Although 22 patients had positive cores of cancer by systematic biopsy (SBx), 8 patients had positive cores of cancer in TBx alone (11.3%). There was a significant difference in cancer detection rate by TBx between two cohorts with PSA < 10 ng/mL (22.9%) and PSA ≥ 10 ng/mL (52.2%) (P < 0.02). Close observation of various CEUS findings with Sonazoid® enabled targeting of cancerous areas, and consequently, a significant difference (P < 0.05) in the detection rate of cancer was recognized in the transition zone (TZ): SBx; 21/120 (17.5%) and TBx; 17/55 (30.9%). The incidence of adverse events was 6.7% and that of adverse reactions was 4%.Conclusions
CEUS with Sonazoid® improved the detection rate of PCa by visualizing cancerous lesions. More detailed examination of CEUS images provided efficient characterization especially in the TZ area. TBx according to this procedure is expected to enable a lower number of biopsies and more accurate diagnosis of PCa. 相似文献52.
Yasuhiko Hirose Takahiro Yasui Kazumi Taguchi Yasuhiro Fujii Kazuhiro Niimi Shuzo Hamamoto Atsushi Okada Yasue Kubota Noriyasu Kawai Yasunori Itoh Keiichi Tozawa Shoichi Sasaki Kenjiro Kohri 《Urological research》2013,41(4):279-294
Renal tubular cell injury induced by oxalate plays an important role in kidney stone formation. Water containing oxygen nano-bubbles (nanometer-sized bubbles generated from oxygen micro-bubbles; ONB) has anti-inflammatory effects. Therefore, we investigated the inhibitory effects of ONB water on kidney stone formation in ethylene glycol (EG)-treated rats. We divided 60 rats, aged 4 weeks, into 5 groups: control, the water-fed group; 100 % ONB, the 100 % ONB water-fed group; EG, the EG treated water-fed group; EG + 50 % ONB and EG + 100 % ONB, water containing EG and 50 % or 100 % ONB, respectively. Renal calcium oxalate (CaOx) deposition, urinary excretion of N-acetyl-β-d-glucosaminidase (NAG), and renal expression of inflammation-related proteins, oxidative stress biomarkers, and the crystal-binding molecule hyaluronic acid were compared among the 5 groups. In the control and 100 % ONB groups, no renal CaOx deposits were detected. In the EG + 50 % ONB and EG + 100 % ONB groups, ONB water significantly decreased renal CaOx deposits, urinary NAG excretion, and renal monocyte chemoattractant protein-1, osteopontin, and hyaluronic acid expression and increased renal superoxide dismutase-1 expression compared with the EG group. ONB water substantially affected kidney stone formation in the rat kidney by reducing renal tubular cell injury. ONB water is a potential prophylactic agent for kidney stones. 相似文献
53.
Mitsuhiro Kamiyoshihara Hitoshi Igai Takashi Ibe Yoichi Ohtaki Jun Atsumi Seshiru Nakazawa Kazumi Tanaka Kai Obayashi Kimihiro Shimizu Izumi Takeyoshi 《General thoracic and cardiovascular surgery》2013,61(5):280-291
Purpose
Most thoracic surgeons have experienced difficulty dissecting the pulmonary hilus because of scarring. In such potentially dangerous situations, we advocate a method of clamping and severing the pulmonary lobar root structure en masse. The aim of this study was to evaluate en masse lobectomy, particularly considering the constellation of pulmonary vessels and the bronchus.Methods
Twelve patients (median age 70 years) underwent en masse lobectomy. We retrospectively evaluated the surgical procedures and clinical outcomes. Care was taken to consider the remaining vessels and bronchus, which regulate the direction of device placement.Results
Seven patients had inflammatory lung disease, four had primary pulmonary carcinoma, and one had suffered blunt chest trauma. Ten operations were elective and two were emergent. Lobectomy included the right upper lobe in two cases, the right middle lobe in three, the right lower lobe in two, the right middle-lower lobe in two, and the left lower lobe in three. A stapler was used in ten patients, and sutures were applied in three (both were used in one case). Morbidities included a pyothorax and a persistent air leak; both made a recovery. Mortality included one emergency case of acute respiratory distress syndrome. No bronchopleural or bronchovascular fistulas occurred.Conclusions
We believe that the en masse lobectomy is an alternative and necessary technique in critical or unexpected situations, possibly as a last resort. Trauma and severe inflammation may be good indications for en masse lobectomy. 相似文献54.
55.
Horinouchi Tomoko Maeyama Kaori Nagai Masashi Mizobuchi Masami Takagi Yasuko Okada Yuka Kato Takeshi Nishimura Mio Kawasaki Yoko Yoshioka Mieko Takada Satoshi Matsumoto Hisayuki Nakamachi Yuji Saegusa Jun Fukushima Sachiyo Fujioka Kazumichi Tomioka Kazumi Nagase Hiroaki Nozu Kandai Iijima Kazumoto Nishimura Noriyuki 《Journal of autism and developmental disorders》2022,52(2):483-489
Journal of Autism and Developmental Disorders - Neonatal jaundice has been suggested as a perinatal risk factor for autism spectrum disorder (ASD). We examined UGT1A1 polymorphisms to assess the... 相似文献
56.
57.
Maeshiro K Sugawara M Sakai A Sugawara K 《Shinrigaku kenkyu : The Japanese journal of psychology》2007,78(2):182-188
This study developed revised Japanese versions of the self-perception profile for Children, for Adolescents and for College Students. The original versions have an idiosyncratic and time-consuming item format, which was revised by using only one statement for each item. Subjects were fifth to sixth grade students (Boys=129, Girls= 152), tenth to twelfth grade students (Boys=112, Girls=100), and college students (Boys=96, Girls=153) in Japan. The reliability and validity measures showed that the revised versions were similar to the original versions. The present study provides some evidence for the use of these scales with Japanese students. 相似文献
58.
59.
Matsuura K Tanaka Y Takagi K Hiramatsu K Kani S Gotoh T Wakimoto Y Joh T Mizokami M 《Rinsho byori. The Japanese journal of clinical pathology》2007,55(11):983-988
The Abbott Real Time HCV assay (lower limit of detection 12 IU/ml) was developed as a highly sensitive HCV RNA quantitative assay using real-time detection PCR(RTD-PCR). We assessed whether the new assay more effectively predicts sustained virological response (SVR) than conventional PCR (PCR) in 38 chronic hepatitis patients infected with HCV genotype 1b and treated with pegylated interferon alpha2b plus ribavirin. Sixteen patients reached SVR, 10 patients relapsed, 9 patients did not respond, 3 patients discontinued treatment. Positive predictive value (PPV) for SVR of undetectable HCV RNA at W4, 8, 12 by RTD-PCR and PCR was (100% vs. 100% at W4), (100% vs. 100% at W8), (83.3% vs. 72.7% at W12). HCV RNA undetectable at W12 had a higher PPV for SVR when measured by RTD-PCR than by conventional PCR. 相似文献
60.