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71.
Satoshi Oki Hideyuki Shirasawa Masaki Yoda Noboru Matsumura Takahide Tohmonda Kazuki Yuasa Masaya Nakamura Morio Matsumoto Keisuke Horiuchi 《Journal of orthopaedic research》2015,33(11):1732-1738
Frozen shoulder is a relatively common disorder that leads to severe pain and stiffness in the shoulder joint. Although this disorder is self‐limiting in nature, the symptoms often persist for years, resulting in severe disability. Recent studies using human specimens and animal models have shown distinct changes in the gene expression patterns in frozen shoulder tissue, indicating that novel therapeutic intervention could be achieved by controlling the genes that are potentially involved in the development of frozen shoulder. To achieve this goal, it is imperative to develop a reliable animal joint contracture model in which gene expression can be manipulated by gene targeting and transgenic technologies. Here, we describe a novel shoulder contracture mouse model. We found that this model mimics the clinical presentation of human frozen shoulder and recapitulates the changes in the gene expression pattern and the histology of frozen shoulder and joint contracture in humans and other larger animal models. The model is highly reproducible, without any major complications. Therefore, the present model may serve as a useful tool for investigating frozen shoulder etiology and for identifying its potential target genes. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1732–1738, 2015. 相似文献
72.
A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma 总被引:35,自引:0,他引:35
Shiina S Teratani T Obi S Sato S Tateishi R Fujishima T Ishikawa T Koike Y Yoshida H Kawabe T Omata M 《Gastroenterology》2005,129(1):122-130
BACKGROUND & AIMS: Percutaneous radiofrequency ablation is a recently introduced treatment for hepatocellular carcinoma, whereas ethanol injection is now a standard therapy. We compared their long-term outcomes. METHODS: Two hundred thirty-two patients with hepatocellular carcinoma who had 3 or fewer lesions, each 3 cm or less in diameter, and liver function of Child-Pugh class A or B were entered onto a randomized controlled trial. The primary end point was survival, and the secondary end points were overall recurrence and local tumor progression. RESULTS: One hundred eighteen patients were assigned to radiofrequency ablation and 114 to ethanol injection. The number of treatment sessions was smaller (2.1 times vs 6.4 times, respectively, P < .0001) and the length of hospitalization was shorter (10.8 days vs 26.1 days, respectively, P < .0001) in radiofrequency ablation than in ethanol injection. Four-year survival rate was 74% (95% CI: 65%-84%) in radiofrequency ablation and 57% (95% CI: 45%-71%) in ethanol injection. Radiofrequency ablation had a 46% smaller risk of death (adjusted relative risk, 0.54 [95% CI: 0.33-0.89], P = .02), a 43% smaller risk of overall recurrence (adjusted relative risk 0.57 [95% CI: 0.41-0.80], P = .0009), and an 88% smaller risk of local tumor progression (relative risk, 0.12 [95% CI: 0.03-0.55], P = .006) than ethanol injection. The incidence of adverse events was not different between the 2 therapies. CONCLUSIONS: Judging from higher survival but similar adverse events, radiofrequency ablation is superior to ethanol injection for small hepatocellular carcinoma. 相似文献
73.
Kazuki Kurihara Hiroshi Kawaguchi Takayuki Obata Hiroshi Ito Eiji Okada 《Biomedical optics express》2015,6(9):3197-3209
Subject-specific head models of which their geometry is based on structural magnetic resonance images are essential to accurately estimate the spatial sensitivity profiles for image reconstruction in diffuse optical tomography. T1-weighted magnetic resonance images, which are commonly used for structural imaging, are not sufficient for the threshold-based segmentation of the superficial tissues. Two types of pulse sequences, which provide a high contrast among the superficial tissues, are introduced to complement the segmentation to construct the subject-specific head models. The magnetic resonance images acquired by the proposed pulse sequences are robust to the threshold level and adequate for the threshold-based segmentation of the superficial tissues compared to the T1- and T2-weighted images. The total scan time of the proposed pulse sequences is less than one-fourth of that for the T2-weighted pulse sequence.OCIS codes: (170.2655) Functional monitoring and imaging, (170.3660) Light propagation in tissues 相似文献
74.
Hideki Ishikura Takeya Ono Sadaaki Oki Yasukazu Saito Namiko Umei Wakako Tsumiyama Atsushi Tasaka Kazuki Aihara Yuta Sato Tomohiro Matsumoto Akira Otsuka 《Journal of Physical Therapy Science》2015,27(9):2821-2823
[Purpose] The purpose of this study was to investigate how a stretching torque affects
muscular contractures. [Subjects] The subjects of this study were 48 male Wistar rats.
[Methods] Subjects were divided into 4 groups as follows: Group 1 was the control; Group 2
had muscles in continuous fixation; Group 3 had muscles stretched in the direction of
dorsiflexion by a spring balancer set at a torque of 0.3N for a period of 30 minutes after
continuous fixation; and Group 4 had muscles stretched in the direction of dorsiflexion by
a spring balancer set at a torque of 3.0N for a period of 30 minutes after continuous
fixation. Joint fixation periods were for 2 and 4-weeks. Ankle joint range of motion and
soleus flexibility were analyzed. [Results] For the 2-week joint fixation, soleus
flexibility in Group 4 showed an increase compared with that of Group 3. For both fixation
periods, range of motion in Group 4 showed an increase compared with that of Group 3.
[Conclusion] For both fixation periods, stretching improved joint range of motion. In the
2-week joint fixation, soleus flexibility improved. However, soleus flexibility did not
improve in the 4-week joint fixation.Key words: Muscular contracture, Stretching, Muscular flexibility 相似文献
75.
Yasunobu Yamashita MD Jun Kato MD PhD Kazuki Ueda MD PhD Yasushi Nakamura MD PhD Hiroko Abe MD Takashi Tamura MD Masahiro Itonaga MD Takeichi Yoshida MD PhD Hiroki Maeda MD Kosaku Moribata MD PhD Toru Niwa MD PhD Takao Maekita MD PhD Mikitaka Iguchi MD PhD Hideyuki Tamai MD PhD Masao Ichinose MD PhD 《Journal of clinical ultrasound : JCU》2015,43(2):89-97
76.
Hiromi Tateno MD PhD Ryuji Sakakibara MD PhD Shunsuke Shiina BSci Hirokazu Doi PhD Fuyuki Tateno MD PhD Mitsutoshi Sato PhD Tohru Masaka PhD Masahiko Kishi MD PhD Yohei Tsuyusaki MD Yosuke Aiba MD Tsuyoshi Ogata MSc Yasuo Suzuki MD PhD 《Journal of the American Geriatrics Society》2015,63(11):2416-2418
77.
78.
Kazuki Nonaka Noriaki Kume Yoshishige Urata Shinji Seto Takaaki Kohno Sumihisa Honda Soji Ikeda Takahiro Muroya Yosihiko Ikeda Yoshito Ihara Toru Kita Takahito Kondo 《Circulation journal》2007,71(1):100-105
BACKGROUND: Oxidative stress plays a role in the development of chronic peripheral arterial disease (PAD) because under these conditions redox regulation is impaired, inducing the S-glutathionylation of proteins. A method of estimating the levels of S-glutathionylated proteins has been developed using biotinylated glutathione S-transferase, which allows the study of their crucial role in the oxidative stress-related progression of PAD. METHODS AND RESULTS: The serum levels of S-glutathionylated proteins were examined in 41 patients with arteriosclerosis obliterans (ASO) and 38 age-matched non-ASO patients using biotinylated glutathione S-transferase. The levels were higher in the patients with ASO, even early on, and positively correlated with the ankle/brachial index. In vitro, the levels of S-glutathionylated proteins were reduced in the presence of glutathione and glutaredoxin. CONCLUSIONS: Serum levels of S-glutathionylated proteins are a sensitive risk-marker for ASO at an early stage. 相似文献
79.
Akihiro Nakamura Yuto Monma Shoko Kajitani Kazuki Noda Sota Nakajima Hideaki Endo Tohru Takahashi Eiji Nozaki 《Heart and vessels》2016,31(9):1446-1455
Both postprandial hyperlipidemia and hyperinsulinemia have been thought to play an important role in the development of atherosclerosis, and to be a potent risk factor for cardiovascular event. To examine effects of glycemic state on postprandial hyperlipidemia and hyperinsulinemia in patients with coronary artery disease (CAD), a total of 112 consecutive male patients with angiographically confirmed CAD were loaded with a high-fat and high-glucose test meal. CAD patients were divided into three groups as “non-diabetic”, “prediabetic”, and “diabetic” CAD groups. The serum triglyceride (TG) and remnant-like particle cholesterol (RLP-C) levels at the 6th hour in diabetic CAD group showed significantly higher than non-diabetic CAD group, and the incremental area under the curves (iAUCs) of these levels in diabetic CAD group were significantly greater than non-diabetic CAD group (TG, P = 0.0194; RLP-C, P = 0.0219). There were no significant differences in the iAUCs of TG or RLP-C between prediabetic and non-diabetic CAD group. The AUCs of plasma insulin levels or insulin resistance index (IRI): (AUCs of insulin) × (AUCs of glucose) as the insulin resistance marker were greater in diabetic CAD group than non-diabetic CAD group (insulin, P = 0.0373; IRI, P = 0.0228). The AUCs of serum TG or RLP-C levels showed a correlation with the AUCs of plasma insulin (AUC-TG, r = 0.5437, P < 0.0001; AUC-RLP-C, r = 0.6847, P < 0.0001), and they correlated well with the insulin resistance index (AUC-TG, r = 0.7724, P < 0.0001; AUC-RLP-C, r = 0.7645, P < 0.0001). We found that the insulin resistance showed a close relationship with postprandial hyperlipidemia in CAD patients. Diabetic, but not prediabetic state, may be a risk for postprandial impaired lipid metabolism in CAD patients. 相似文献