全文获取类型
收费全文 | 15892篇 |
免费 | 734篇 |
国内免费 | 164篇 |
专业分类
耳鼻咽喉 | 182篇 |
儿科学 | 260篇 |
妇产科学 | 125篇 |
基础医学 | 1902篇 |
口腔科学 | 368篇 |
临床医学 | 1045篇 |
内科学 | 4218篇 |
皮肤病学 | 305篇 |
神经病学 | 1264篇 |
特种医学 | 619篇 |
外科学 | 2893篇 |
综合类 | 55篇 |
预防医学 | 468篇 |
眼科学 | 163篇 |
药学 | 1047篇 |
中国医学 | 18篇 |
肿瘤学 | 1858篇 |
出版年
2023年 | 103篇 |
2022年 | 166篇 |
2021年 | 356篇 |
2020年 | 214篇 |
2019年 | 261篇 |
2018年 | 330篇 |
2017年 | 268篇 |
2016年 | 326篇 |
2015年 | 336篇 |
2014年 | 461篇 |
2013年 | 564篇 |
2012年 | 906篇 |
2011年 | 931篇 |
2010年 | 519篇 |
2009年 | 452篇 |
2008年 | 843篇 |
2007年 | 878篇 |
2006年 | 909篇 |
2005年 | 944篇 |
2004年 | 938篇 |
2003年 | 878篇 |
2002年 | 902篇 |
2001年 | 374篇 |
2000年 | 356篇 |
1999年 | 430篇 |
1998年 | 262篇 |
1997年 | 191篇 |
1996年 | 197篇 |
1995年 | 153篇 |
1994年 | 142篇 |
1993年 | 125篇 |
1992年 | 218篇 |
1991年 | 218篇 |
1990年 | 172篇 |
1989年 | 191篇 |
1988年 | 204篇 |
1987年 | 152篇 |
1986年 | 142篇 |
1985年 | 137篇 |
1984年 | 88篇 |
1983年 | 57篇 |
1982年 | 37篇 |
1981年 | 38篇 |
1980年 | 27篇 |
1979年 | 66篇 |
1978年 | 52篇 |
1977年 | 31篇 |
1975年 | 36篇 |
1971年 | 22篇 |
1969年 | 24篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
K Ohtsuka K Tsuji Y Nakagawa H Ueda O Ozawa T Uchida T Ichikawa 《Journal of nutritional science and vitaminology》1990,36(3):265-276
O-beta-D-Galactopyranosyl-(1----4)-O-beta-D-galactopyranosyl-(1----4)-D- glucopyranose (designated as 4'GL) is produced from lactose by Cryptococcus laurentii. The influence of chronic ingestion of 4'GL on body weight gain, organ weight, serum lipids, and liver lipids was investigated in rats. The body weight gains of the 5% and 10% 4'GL-diet groups were higher than that of the control group. Food intake and fecal dry weight were significantly increased (p less than 0.05) by 4'GL feeding. The 4'GL diet produced a significant increase (p less than 0.01) in the wet weight and contents of both the cecum and the colon. However, no significant increase was observed in the weight of the stomach, small intestine, liver, or other organs. The effects of 4'GL on serum and liver lipid levels were not observed in this experiment. The digestion of 4'GL was measured in vitro using the artificial gastric juice, alpha-amylase of human saliva, alpha-amylase of hog pancreas, and mucosa of rat intestine. 4'GL was not hydrolyzed by these enzymes. Long-term ingestion of 4'GL did not cause any induction of 4'GL hydrolyzing enzyme activity in the rat small intestine. 相似文献
22.
23.
Yuichi Sanada Kazuhiro Yoshida Hiroyuki Itoh Satoko Kunita Kazuto Jinushi Hideo Matsuura 《Journal of hepato-biliary-pancreatic sciences》2007,14(4):401-409
We report a case of groove pancreatitis (GP) associated with a true pancreatic cyst. An 81-year-old man who had suffered epigastric pain for 4 months was referred to Saisekai Kure Hospital. Computed tomography and endoscopic retrograde pancreatography showed a cystic lesion in the groove area of the pancreas. Serum amylase elevation and imaging findings suggested GP due to the cyst. Six weeks of medical treatment did not improve the clinical symptoms. Therefore, pancreatoduodenectomy was performed. Histologic examination revealed a true cyst with intraluminal necrosis, which produced a protein plug that obstructed the Santorini duct. The parenchyma surrounding the groove area showed marked fibrosis and inflammatory cell infiltration. GP due to true pancreatic cyst was diagnosed. Although GP is usually caused by overconsumption of alcohol, which leads to changes in the pancreatic juice and the ultimate blockage of pancreatic outflow, the histologic features in our patient suggest that true pancreatic cyst stands as a secondary cause of GP. 相似文献
24.
25.
Skip mediastinal nodal metastases in non-small cell lung cancer 总被引:1,自引:0,他引:1
Fumihiro Tanaka Kazumasa Takenaka Hiroki Oyanagi Takuji Fujinaga Yosuke Otake Kazuhiro Yanagihara Harumi Ito Hiromi Wada 《European journal of cardio-thoracic surgery》2004,25(6):744-1120
Objective: To reveal the incidence and clinical significance of mediastinal nodal metastases without N1-station nodal metastases (‘skip-N2 metastases’) in non-small cell lung cancer (NSCLC). Methods: A total of 450 NSCLC patients who underwent tumor resection with a systemic mediastinal nodal dissection were retrospectively reviewed. p53 status and proliferative activity represented as proliferative index (PI) were also examined immunohistochemically. Results: Skip-N2 metastases were documented in 49 (13%) patients of all 450 patients; among 334 patients without N1-nodal involvement, 18% patients had skip-N2 metastases. The postoperative survival of skip-N2 patients was almost same as that for patients with metastases to both N1 and N2 nodes. Skip-N2 metastases were significantly more frequent in male patients and squamous cell carcinoma patients. In addition, the mean PI for tumor with skip-N2 metastases was significantly higher than that for any other pathologic nodal (pN)-status diseases. Combined with histologic type and PI, the incidences of skip-N2 metastases for adenocarcinoma showing lower PI were only 5% (7/137) of all patients and 7% (7/94) of patients without N1-nodal involvement. Conclusions: N1 nodal status is not a useful predictor of N2 nodal status in NSCLC, because skip-N2 metastases were documented in 18% patients showing no N1-nodal involvement. However, N1 node-guided dissection might be performed in patients with adenocarcinoma showing lower PI, because the incidence of skip-N2 metastases was extremely low. 相似文献
26.
Kazumasa Miyake Atsushi Tatsuguchi Mikiko Tachibana Masanobu Kusunoki Yoko Shinji Kei Shinoki Tetsuro Hiratsuka Kazuhiro Nagata Hitoshi Nishigaki Seiji Futagami Ken Wada Taku Tsukui Toshiro Yoshiyuki Akira Tokunaga Takashi Tajiri Choitsu Sakamoto 《Digestive endoscopy》2004,16(2):172-175
A 52‐year‐old Japanese woman who presented with gastrointestinal (GI) bleeding underwent a proximal gastrectomy for a gastrointestinal stromal tumor (GIST) with a foveolar hyperplasia at the apex of the tumor, 4.5 cm in size, located in the upper body of the stomach. Although GIST are often asymptomatic and are found only incidentally, clinical symptoms such as bleeding, abdominal pain, or obstruction, occasionally lead to a premorbid diagnosis. When submucosal tumors present GI bleeding, the source of the bleeding usually is an ulceration of the mucosa over the tumor. However, in the present study, it was thought that the bleeding originated from the region of foveolar hyperplasia. 相似文献
27.
28.
29.
A Tsuji M Takao T Asano T Fujioka H Nakamura K Mukai 《Hinyokika kiyo. Acta urologica Japonica》1987,33(5):738-742
A black adenoma of the adrenal cortex was surgically removed from an 18-year-old female who had clinical and laboratory findings characteristic of Cushing's syndrome. The electron microscopic study revealed typical features of steroid-producing cells, including a prominent smooth and rough endoplasmic reticulum, and mitochondria. In addition, many of the adenoma cells contained numerous pigmented granules which were lipofuscin. Three months after the surgery, the hormone levels returned to the normal range. The Japanese literature of functional black adenoma is reviewed. 相似文献
30.
E Nakashima K Yokogawa F Ichimura T Hashimoto T Yamana A Tsuji 《Journal of pharmaceutical sciences》1987,76(1):10-13
The effects of fasting on the pharmacokinetics of biperiden in rats were examined. Total clearance of biperiden was greater than 90% ascribable to hepatic clearance and was essentially blood-flow dependent. The number of compartments in the preferred pharmacokinetic model of biperiden changed from three (for normal rats) to two (for fasted rats). The smaller mean residence time (MRT) values found for fasted rats were attributable to decreases in distribution volume. Biperiden showed much higher lipophilicity than haloperidol, thiopental, and hexobarbital, and its tissue-to-plasma partition coefficient in adipose tissue was 20-fold higher than that in muscle. The influence of changes in volumes of adipose tissue and muscle on distribution volume (Vdss/BW) was evaluated from tissue-to-plasma partition coefficients. The value of Vdss/BW was predicted to decrease with decrease of adipose tissue, and to increase with decrease of muscle tissue. These results suggest that the observed decrease of Vdss/BW in fasted rats reflects reduced capacity to trap biperiden in the body, especially in adipose tissue. Possible clinical implications of these results are discussed. 相似文献