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991.
992.
Ito A Nishikawa Y Ohnuma K Ohnuma I Koma Y Sato A Enomoto K Tsujimura T Yokozaki H 《Hepatology (Baltimore, Md.)》2007,45(3):684-694
Spermatogenic immunoglobulin superfamily (SgIGSF) is an intercellular adhesion molecule of the nectin-like family. While screening its tissue distribution, we found that it was expressed in fetal liver but not adult liver. In the present study, we examined which cells in developing and regenerating liver express SgIGSF via immunohistochemistry and Western blot analysis. In developing mouse liver, SgIGSF expression was transiently upregulated at perinatal ages and was restricted to the lateral membrane of biliary epithelial cells (BECs). In regenerating rat livers from the 2-acetylaminofluorene/partial hepatectomy model, SgIGSF was detected exclusively in oval cells that aligned in ductal and trabecular patterns by the second week posthepatectomy. In human livers, fetal and newborn bile ducts and cirrhotic bile ductules were clearly positive for SgIGSF, whereas disease-free adult bile ducts were negative. To investigate the role of SgIGSF in bile duct/ductule formation, we used an in vitro model in which rat hepatocyte aggregates embedded in collagen gels containing insulin and epidermal growth factor extend epithelial sheets and processes in the first week and form ductules within a month. The process and ductular cells were continuously positive for SgIGSF and cytokeratin 19, a BEC marker. When the aggregate culture was started in the presence of a function-blocking anti-SgIGSF antibody, the number of epithelial processes per aggregate was reduced by 80%. CONCLUSION: We propose that SgIGSF is a novel and functional BEC adhesion molecule that is expressed for a limited time during active bile duct/ductule formation. 相似文献
993.
Mori H Sakai H Sanada M Shimamoto K Sasaki S Azuma R Higuchi T Harada H Niikura H Omine M Fujita K Takahashi N 《[Rinshō ketsueki] The Japanese journal of clinical hematology》2007,48(7):547-553
The type of leukemia was defined as HLA-DR(-) non-M3-AML, when HLA antigens were detected by flow cytometry at an incidence of < 20% of the blast population excluding M3-AML. Out of 109 patients with de novo acute myeloid leukemia, 8 patients had HLA-DR(-) non-AML-M3. According to the French-American-British criteria, 7 patients could be subdivided into 3 patients with M1, 4 patients with M2 and 1 patient with M4. The morphological features of bone marrow aspiration demonstrated no dysplasia and peroxidase stain positivity was noted in over 86% of the blast cells in all patients, the blast cells with fine granularity in 7 patients. The cytogenetic analysis revealed a normal karyotype. There was no expression marker of the blast antigens except CD13, CD14, CD33, CD34 and CD56. All of 7 patients who underwent induction therapy attained complete remission. Overall survival and disease-free survival showed no significant differences between the HLA-DR(-) non- M3-AML group and the HLA-DR(+) AML group. 相似文献
994.
Hoshino N Nakase K Tawara I Kageyama S Ohishi K Nishii K Sugimura Y Shiku H Katayama N 《Internal medicine (Tokyo, Japan)》2007,46(6):291-293
We describe a 65-year-old man who had repeated lung injuries after reduced-intensity allogeneic stem cell transplantation (RIST) for renal cell carcinoma. Severe pneumonitis developed twice at the time of neutrophil recovery and acute graft-versus-host disease. Both episodes were successfully treated with steroid pulse therapy. Metastases regressed after the first episode and were stable during these lung disorders, but he died of tumor progression 6 months after RIST. This case suggests that certain local inflammatory reactions may be associated with an anti-tumor effect. 相似文献
995.
996.
Naito S Sato K Yoshida K Higuchi H Takahashi H Kamata M Ito K Ohkubo T Shimizu T 《Psychiatry and clinical neurosciences》2007,61(4):421-427
Gender differences in the treatment response to fluvoxamine (selective serotonin re-uptake inhibitor) and milnacipran (serotonin/norepinephrine re-uptake inhibitor) were investigated in Japanese major depressive patients. A total of 125 Japanese patients was included in the present study. Sixty-six patients received fluvoxamine treatment. The daily dose was 50 mg/day for the first week and increased to 100 mg after 1 week, up to 200 mg after another week. Fifty-nine patients were given milnacipran. The daily dose was 50 mg/day for the first week, and up to 100 mg/day thereafter. Patients were divided into three groups: younger women (<44 years of age), older women (> or =44 years of age) and men. Depressive symptoms were evaluated using the Montgomery and Asberg Depression Rating Scale (MADRS) before treatment and at 1, 2, 4 and 6 weeks after the beginning of the study. In comparison with other groups, younger women treated with fluvoxamine demonstrated a significant difference in the time course of MADRS score change. However, these gender/age-related differences of antidepressant response were not observed in the patients treated with milnacipran. The results suggest that fluvoxamine is more effective in younger female patients than older female patients and male patients, while milnacipran is generally effective irrespective of gender or age. 相似文献
997.
Ukai S Yamamoto M Tanaka M Shinosaki K Takeda M 《Psychiatry and clinical neurosciences》2007,61(2):190-192
Musical hallucinations (MH) typically occur among elderly individuals and are associated with hearing impairment. The authors describe a patient with features of typical MH who was successfully treated with donepezil, a cholinesterase inhibitor, as a combination therapy and who has not shown any subsequent cognitive decline for approximately 5 years. The efficacy of donepezil in this patient indicates that age-dependent dysfunction of cholinergic neurons might be related to the development of MH. 相似文献
998.
Kinuya S Yokoyama K Fukuoka M Hiramatsu T Mori H Shiba K Watanabe N Shuke N Michigishi T Tonami N 《Nuclear medicine communications》2007,28(2):129-133
BACKGROUND AND AIM: In patients with a high risk of peritoneal dissemination of colon cancer, a treatment adjuvant to surgical resection would improve their prognosis. We aimed to determine whether radioimmunotherapy employing radiolabelled monoclonal antibody would work in this situation. METHODS: A murine model of peritoneal dissemination was established in female Balb/c nu/nu mice by intraperitoneal injection of LS180 human colon cancer cells. Radioimmunotherapy with 7.4 MBq of a murine IgG1, anti-colorectal A7 monoclonal antibody, radiolabelled with (131)I by the chloramine-T method was conducted intraperitoneally on days 0, 3, 7 and 14 after cell inoculation, respectively. RESULTS: Radioimmunotherapy at any timing improved survival of mice as compared with those of non-treated mice and mice treated with a daily dose of 30 mg x kg(-1) of 5-fluorouracil for 4 consecutive days. The best improvement was obtained when radioimmunotherapy was conducted on day 0. CONCLUSION: These results indicate that intraperitoneal radioimmunotherapy may effectively kill colon cancer cells disseminated in the peritoneal cavity before formation of tumours and, therefore, may work as an adjuvant treatment to prevent peritoneal metastasis of colon cancer. 相似文献
999.
Diagnostic image features of the omental cyst remain to be fully understood because of its rarity. We present here a case
of omental cyst in a 29-year-old man involving several diagnostic image features. Contrasted computed tomography showed thin
ring-like enhancement, and angiography revealed the feeding arteries that branched from the right gastroepiploic artery. The
cyst was excised surgically, and the final pathological diagnosis was an omental pseudocyst. 相似文献
1000.
Purpose The purpose of this study was to assess the influence of liquid crystal display (LCD) monitors on the detectability of diffuse
pulmonary diseases depicted on chest radiographs by comparing them with a high-resolution cathode ray tube (CRT) monitor.
Materials and methods A group of 17 radiologists interpreted 87 soft-copy images on LCD monitors with pixel arrays of 1024 × 1280, 1200 × 1600,
1536 × 2048, and 2048 × 2560 and on a CRT monitor with a pixel array of 2048 × 2560. They were asked to indicate their individual
confidence levels regarding the presence of diffuse pulmonary diseases. The luminance distributions of all monitors were adjusted
to the same distributions, and the ambient illumination was 200 lux. Observer performance was analyzed in terms of the receiver
operating characteristics (ROC).
Results The average ROC curves for the five monitor types were similar, and there were no statistically reliable effects of the five
monitor types on the readers’ diagnostic performances (P = 0.7587).
Conclusion The detectability of diffuse pulmonary disease on the LCD monitors with a spatial resolution equal to or higher than a matrix
size of 1024 × 1280 was found to be equivalent to that on the high-resolution CRT monitor. 相似文献