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991.
Kasai K Ushio A Kasai Y Sawara K Miyamoto Y Oikawa K Kuroda H Takikawa Y Suzuki K 《International journal of clinical oncology / Japan Society of Clinical Oncology》2011,16(3):221-229
Background
This study evaluated the efficacy of combined 5-fluorouracil (5-FU) and pegylated interferon (PEG-IFN) α-2b in patients with advanced hepatocellular carcinoma (HCC). 相似文献992.
993.
We describe the successful use of a combination of nonsurgical root canal treatment and ultrasonic irrigation for collaborative management of a maxillary left lateral incisor with perforation of the apical third of the root. During the endodontic treatment procedure, the ultrasonically activated tip was used for intracanal irrigation. The area of perforation in the apical third of the root and the main root canal space were obturated with gutta-percha and root canal sealer, using a lateral condensation method. A follow-up clinical and radiographic examination at 5 years after treatment showed an asymptomatic tooth with excellent osseous healing. 相似文献
994.
Kazuhiro Tada Kiyoshi Kakuta Hideo Ogura Soh Sato 《Odontology / the Society of the Nippon Dental University》2010,98(1):31-36
We examined the abrasiveness of glycine powders with particle diameters of 63 and 100 μm by measuring the depth and volume
of defects produced during air polishing of human dentin. A total of 36 extracted human teeth were embedded in acrylic resin.
The resin blocks were polished until the dentin surfaces were exposed. The nozzle of an air polisher was mounted 4 mm from
the dentin surface, and the dentin surface was treated for 5 s at one of two angles of incidence (45° or 90°). Three materials
were used in the polishing process: NaHCO3 powder with a mean particle diameter of 100 μm (Handy Jet Powder), glycine powder with a mean particle diameter of 63 μm
(Handy Jet Powder PMTC), and glycine powder with a mean particle diameter of 100 μm (Handy Jet Powder Recall). The defect
depth at both angles was significantly deeper after treatment with Handy Jet Powder or Handy Jet Powder PMTC. The defect volume
was the greatest with Handy Jet Powder, followed by Handy Jet Powder PMTC, and Handy Jet Powder Recall. The larger diameter
glycine powder resulted in less damage to the dentin. 相似文献
995.
Akira Ito Gurbadam Agvaandaram Oyun-Erdene Bat-Ochir Batsaikhan Chuluunbaatar Nyamkhuu Gonchigsenghe Tetsuya Yanagida Yasuhito Sako Narankhajid Myadagsuren Temuulen Dorjsuren Kazuhiro Nakaya Minoru Nakao Yuji Ishikawa Abmed Davaajav Nyamkhuu Dulmaa 《The American journal of tropical medicine and hygiene》2010,82(2):266-269
The combined efficacy of a long-lasting insecticidal net (LLIN) and a carbamate-treated plastic sheeting (CTPS) or indoor residual spraying (IRS) for control of insecticide-resistant mosquitoes was evaluated in experimental huts in Burkina Faso. Anopheles gambiae from the area is resistant to pyrethroids and to a lesser extent, carbamates. Relatively low mortality rates were observed with the LLIN (44%), IRS (42%), and CTPS (52%), whereas both combinations killed significantly more mosquitoes (~70% for LLIN + CTPS and LLIN + IRS). Blood feeding by An. gambiae was uninhibited by IRS and CTPS compared with LLIN (43%), LLIN + CTPS (58%), and LLIN + IRS (56%). No evidence for selection of the kdr and ace-1R alleles was observed with the combinations, whereas a survival advantage of mosquitoes bearing the ace-1R mutation was observed with IRS and CTPS. The results suggest that the combination of the two interventions constitutes a potential tool for vector-resistance management. 相似文献
996.
997.
Hideo Ochiai Kazuo Takeda Yoshikazu Tahara Kazuhiro Abe Shunsuke Noguchi Masumi Inoue Wolfgang Schwarz Masaru Kawamura 《Biochemical pharmacology》2009,78(8):1069-124
Four catechins, epigallocatechin-3-gallate, epigallocatechin, epicatechin-3-gallate, and epicatechin, inhibited activity of the Na+,K+-ATPase. The two galloyl-type catechins were more potent inhibitors, with IC50 values of about 1 μM, than were the other two catechins. Inhibition by epigallocatechin-3-gallate was noncompetitive with respect to ATP. Epigallocatechin-3-gallate reduced the affinity of vanadate, shifted the equilibrium of E1P and E2P toward E1P, and reduced the rate of the E1P to E2P transition. Epigallocatechin-3-gallate potently inhibited membrane-embedded P-type ATPases (gastric H+,K+-ATPase and sarcoplasmic reticulum Ca2+-ATPase) as well as the Na+,K+-ATPase, whereas soluble ATPases (bacterial F1-ATPase and myosin ATPase) were weakly inhibited. Solubilization of the Na+,K+-ATPase with a nonionic detergent reduced sensitivity to epigallocatechin-3-gallate with an elevation of IC50 to 10 μM. These results suggest that epigallocatechin-3-gallate exerts its inhibitory effect through interaction with plasma membrane phospholipid. 相似文献
998.
Nkouawa A Okamoto M Mabou AK Edinga E Yamasaki H Sako Y Nakao M Nakaya K Blair D Agatsuma T Enyong P Shibahara T Moyou-Somo R Ito A 《Transactions of the Royal Society of Tropical Medicine and Hygiene》2009,103(3):255-261
Paragonimiasis is a common parasitic zoonosis in Cameroon and neighbouring countries in Western Africa. Serum, sputum and faecal samples were collected in an endemic area of South West Province, Cameroon, after administration of a questionnaire to identify individuals with appropriate symptoms and histories. Microscopic examination revealed eggs in sputum from 16 people, but none in any faecal sample. These 16 were among the 25 and 26 people, respectively, positive by ELISA and by immunoblot using Paragonimus africanus crude antigens. Copro-DNA detection was attempted using 23 faecal samples (18 from sputum egg-negative and five from sputum egg-positive individuals). Copro-DNA was detected in four of the five sputum egg-positive individuals. These results strongly suggest that: (1) serology is much more sensitive than sputum examination for diagnosis of paragonimiasis; and (2) a copro-DNA test may be more sensitive than a microscopic search for eggs in faeces. Molecular sequence data from ITS2 and cox1 genes confirmed that adult worms experimentally raised in cats were P. africanus and that eggs from sputum or other worm products from human faeces also belonged to this species. Based on these results, 26 of 168 persons (15.5%) were diagnosed as suffering from paragonimiasis. 相似文献
999.
Yasuhiro Nojima Yosuke Suzuki Kazuhiro Yoshida Fumiko Abe Tuneo Shiga Takashi Takeuchi Akihiko Sugiyama Hirohiko Shimizu Atsushi Sato 《Pharmaceutical research》2009,26(9):2125-2132
Purpose We developed a lactoferrin conjugate by modifying bovine lactoferrin (bLF) with a 40-kDa branched poly(ethylene glycol) (PEG)
molecule (designated 40 k-PEG-bLf), and we evaluated its in vitro activities and pharmacokinetic properties.
Materials and Methods We prepared 40k-PEG-bLf by amino conjugation with N-hydroxysuccinimide-activated PEG. This conjugate was purified by cation exchange chromatography and its in vitro biological activities, such as iron binding, anti-inflammatory effects, and resistance to proteolytic enzymes were investigated.
In vivo pharmacokinetics analyses, were also performed to examine the rate of clearance from the plasma in rats.
Results The 40k-PEG-bLf conjugate was fully active in iron binding and exhibited 97.1 ± 5.5% (mean ± S.E., n = 6) of the original anti-inflammatory activity. The in vitro peptic susceptibility of 40 k-PEG-bLf revealed that the proteolytic half-life increased at least 6-fold that of unmodified
LF. This PEGylated conjugate demonstrated a plasma half-life that was 8.7-fold longer than that of the unmodified bLF in rats.
Conclusions The 40k-PEG-bLf exhibited improved in vitro bioactivity and stability and enhanced pharmacokinetic properties as compared to those of the unmodified bLF and the 20 k-PEG-bLf
conjugate, which was recently developed by PEGylation of bLF with a 20-kDa branched PEG [Nojima Y. et al. Bioconjugate Chem. 19:2253–2259 (2008)]. 相似文献