收费全文 | 775篇 |
免费 | 70篇 |
国内免费 | 1篇 |
耳鼻咽喉 | 11篇 |
儿科学 | 23篇 |
妇产科学 | 10篇 |
基础医学 | 113篇 |
口腔科学 | 4篇 |
临床医学 | 126篇 |
内科学 | 179篇 |
皮肤病学 | 3篇 |
神经病学 | 81篇 |
特种医学 | 8篇 |
外科学 | 52篇 |
综合类 | 2篇 |
一般理论 | 1篇 |
预防医学 | 112篇 |
眼科学 | 7篇 |
药学 | 64篇 |
中国医学 | 1篇 |
肿瘤学 | 49篇 |
2024年 | 1篇 |
2023年 | 19篇 |
2022年 | 28篇 |
2021年 | 70篇 |
2020年 | 44篇 |
2019年 | 52篇 |
2018年 | 44篇 |
2017年 | 38篇 |
2016年 | 22篇 |
2015年 | 33篇 |
2014年 | 28篇 |
2013年 | 48篇 |
2012年 | 72篇 |
2011年 | 63篇 |
2010年 | 19篇 |
2009年 | 16篇 |
2008年 | 23篇 |
2007年 | 41篇 |
2006年 | 30篇 |
2005年 | 23篇 |
2004年 | 23篇 |
2003年 | 38篇 |
2002年 | 21篇 |
2001年 | 6篇 |
2000年 | 5篇 |
1999年 | 2篇 |
1998年 | 5篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1992年 | 2篇 |
1991年 | 7篇 |
1990年 | 7篇 |
1989年 | 3篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 3篇 |
1973年 | 1篇 |
- WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC?
- WHAT QUESTION DID THIS STUDY ADDRESS?
- WHAT DOES THIS STUDY ADD TO OUR KNOWLEDGE?
- HOW MIGHT THIS CHANGE CLINICAL PHARMACOLOGY OR TRANSLATIONAL SCIENCE?
Method: Seventy-five individuals (Mage = 73.9 years, range = 55–88 years; 56% female) with MCI–ASD (n = 30) and MCI–AMD (n = 45) were recruited primarily from a hospital-based memory disorders clinic. Participants were administered self-report and objective measures assessing six functional domains: financial management, driving, telephone use, nutrition evaluation, grocery shopping, and medication management. Self-awareness discrepancy scores were calculated for each of these IADLs, and participants were classified as either “overestimating ability” or “accurately/underestimating ability.”
Results: Individuals with MCI–AMD performed significantly worse on objective measures of financial management, driving, and nutrition evaluation than those with MCI–ASD. Across MCI subtypes, participants were most likely to lack awareness of their difficulties in nutrition evaluation (31%), financial management (25%), and driving (23%) domains. Individuals with MCI–AMD were significantly more likely than those with MCI–ASD to overestimate performance on driving and telephone use domains.
Conclusion: Individuals with MCI–AMD are more likely than those with MCI–ASD to have impairment in their everyday function and to lack awareness into their IADL difficulties. When possible, clinicians should obtain objective measures in combination with detailed informant reports of functional abilities in order to evaluate capacity to independently engage in various daily activities. Finally, level of self-awareness varies across IADL domains, providing further evidence that insight is not a unitary construct. 相似文献
- Vasomotor function of the vascular endothelium was examined in human subcutaneous arteries excised from 8 hypercholesterolaemic and 7 normolipidaemic subjects.
- Left gluteal skin biopsies were performed under local anaesthesia. Subcutaneous arteries were isolated and two vessels from each subject mounted in separate myographs. A 20 ml fasting blood sample was taken at the time of the biopsy.
- Hypercholesterolaemic subjects had either never been treated with lipid lowering therapy or therapy had been stopped at least two weeks before the study (n=2). At the time of the study total plasma cholesterol levels (control: 4.6±0.3 vs hypercholesterolaemic: 8.3±0.6 mmol l−1: P<0.01) were significantly elevated in hypercholesterolaemic subjects when compared with controls.
- Full concentration-response curves to the vasoconstrictor noradrenaline and the vasodilators acetylcholine and substance P were constructed. A single point concentration-response to sodium nitroprusside (10 μM) was also obtained. Dilator responses were obtained in vessels pre-constricted with a submaximal concentration of noradrenaline. Vessels were then incubated for 30 min with either L- or D-arginine (10 μM) and the concentration-response curves to the three dilator agonists repeated in the presence of the amino acid.
- Maximum relaxation responses to acetylcholine (control vs hypercholesterolaemic: 83.3±6.1% vs 47.4±13.5%; P<0.05), but not to substance P or sodium nitroprusside, were dampened in the hypercholesterolaemic group when compared with controls.
- Neither incubation with L-arginine nor D-arginine had any effect on maximum relaxation responses to acetylcholine in either the control group (pre L-arginine vs plus L-arginine: 83.3±6.1 vs 82.3±5.5%, pre D-arginine vs plus D-arginine: 98.9±1.2 vs 98.2±1.1%) or the hypercholesterolaemic group (pre L-arginine vs plus L-arginine: 47.4±13.5 vs 55.3±14.3%, pre D-arginine vs plus D-argenine: 43.3±13.6 vs 65.4±12.3%).
- When results from the two study groups were pooled, the strongest predictor of maximum relaxation obtained to acetylcholine was apolipoprotein A1 (r=0.67; P=0.001).
- In conclusion, relaxation responses mediated by the endothelium-dependent agonist acetylcholine, but not by substance P, are impaired in hypercholesterolaemic patients. L-Arginine did not improve the impaired relaxation responses to acetylcholine. We suggest that impaired endothelium-dependent relaxation is specific to acetylcholine and not to an abnormal L-arginine-nitric oxide pathway in subcutaneous arteries excised from this study group.