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排序方式: 共有4564条查询结果,搜索用时 15 毫秒
991.
H V Schaff M Tago B J Gersh J R Pluth J Fetter M P Kaye 《The Journal of thoracic and cardiovascular surgery》1983,85(3):434-439
A method of heterotopic cardiac transplantation has been developed which is performed through a left thoracotomy and requires only two vascular anastomoses. Systemic heparinization and cardiopulmonary bypass are not necessary. Preliminary experiments demonstrated that this heterotopic transplant technique was effective for left ventricular assist; in some experiments, a multimode atrioventricular programmable pacemaker was used to provide sequential pacing for "counterpulsation." This technique or similar techniques may have potential clinical benefit for patients with intractable left ventricular failure. 相似文献
992.
Alain Gouyette David J. Kerr Stan B. Kaye Albert Setanoians James Cassidy Christopher Bradley Gordon Forrest Mike Soukop 《Cancer chemotherapy and pharmacology》1988,22(2):114-119
Summary Flavone acetic acid pharmacokinetics were studied in 31 patients in a phase I clinical trial. The drug was given by i.v. infusions over 1, 1.5, 3, and 6 h at doses ranging from 0.5 to 6.4 g/m2. The pharmacokinetic parameters were determined according to a nonlinear model including Michaelis-Menten-type kinetics. The mean elimination half-life is 4.8 h and the mean volume of distribution of the central compartment, 7.61. Our model predicted a maximal tolerated dose (MTD) of 11.1 g/m2 on the basis of the therapeutic window concept, very close to the clinically observed MTD of 10 g/m2. This model is also operational when different protocols of inoculation are considered, such as a divided-dose schedule vs a unique infusion, and indicates that, at the MTD, injections should be made every 72 h to avoid drug accumulation. 相似文献
993.
L W Kaye 《Home health care services quarterly》1989,10(1-2):177-191
This study documents high levels of role complexity and functional overlap in the field of home health care. Personnel perform a wide range of "professional/organizational" and "community/familial" service functions though the emphasis is on the delivery of a battery of pseudo family-like tasks. The importance of a familial orientation does not significantly decline when controlling for length of employment or organizational rationality. Role orientation is, however, significantly associated with a worker's chronological age. Results lead to program planning recommendations meant to influence staff training paradigms in home health care. 相似文献
994.
A previously developed method based on alpha 1-acid glycoprotein for the resolution of the enantiomers of the Pfizer antischistosomal drug oxamniquine was used to examine possible enantioselectivity in the in vitro microsomal hydroxylation of a metabolic precursor, UK-3883, but was found to be limited by the poor operational stability of the analytical column ("EnantioPac") employed. As an alternative approach, a "Pirkle" covalently-bonded dinitrobenzoyl leucine column was used, with simple precolumn solute derivatization to the carbamate to improve chromatographic performance. The method allowed preliminary examination of the stereochemistry of the in vitro biotransformation, hydroxylation of UK-3883 to oxaminquine, which yielded evidence for substrate enantioselectivity in favour of the dextrorotatory enantiomer of UK-3883. 相似文献
995.
James Cassidy Craig Lewis Lynn Adams Albert Setanoians Martine Bayssas George G. Boder Elaine M. Rankin Stanley B. Kaye 《Cancer chemotherapy and pharmacology》1989,24(4):233-237
Summary LY 195448 is a phenethanolamine that has shown anti-tumour activity in a range of murine tumour models, although its mechanism of action is unknown. Pre-clinical studies have indicated the absence of standard side effects such as myelosuppression and gastrointestinal toxicity. The present phase I trial was carried out in nine patients at doses ranging up to 133 mg/m2. The major toxicities up to that dose were mild, reversible hypotension, tachycardia and tremor. No haematological or biochemical toxicity was observed. Murine pharmacokinetics were assessed at a dose level that was effective in experimental tumours and compared with human pharmacokinetic parameters derived from this study. The results indicated the clinical possibility of reaching peak drug levels associated with experimental activity. However, no responses were seen at the doses used. This study was terminated prior to its completion due to an unexplained loss of activity against murine tumours since September 1987. No significant loss of the in vitro anti-mitotic activity originally reported by Boder et al. [3] was observed. Possible reasons for the apparent loss of in vivo activity have been intensively investigated, but no cause has been determined. Therefore, clinical trials with LY 195448 have been discontinued. 相似文献
996.
B L Herwaldt E T Kaye T J Lepore J D Berman H P Baden 《The Journal of infectious diseases》1992,165(5):968-971
A 27-year-old woman who acquired cutaneous leishmaniasis in Central America was inadvertently treated with 10 times the intended daily dose of the pentavalent antimonial compound sodium stibogluconate (Pentostam): 8500 mg (143 mg/kg) instead of 850 mg. The patient felt "wiped out" during the 4-h infusion of the drug. After the mistake in dosing was discovered, she was vigorously hydrated and carefully monitored in an intensive care unit for greater than 48 h. Her vital signs were stable, and no arrhythmias were noted. Her alanine aminotransferase level rose briefly to 2.4 times the upper limit of normal, and her white blood cell count briefly fell 43% to a low of 3700/microliter. Her skin lesions subsequently healed without further therapy. Although sodium stibogluconate has been associated with a variety of side effects, in this case, a single high dose of the drug was tolerated without serious toxicity. 相似文献
997.
Kaye CF 《Health services management》1990,86(1):16-18
Over the past six or seven years Basingstoke and North Hampshire HA has invested considerable effort in pioneering a particular approach to the provision of care and support to the extremely physically disabled. Charles Kaye describes the development of the service and pursuit of quality assurance. 相似文献
998.
999.
C. Alexandre A. Rampazzo G. Martinez Z. Prost D. Willard K. Kaye A. de Gaulmyn D. Durazzi C. Doyen R. Gaillard M.O. Krebs Y. Contejean I. Amado 《Neuropsychiatrie de l'enfance et de l'adolescence》2013,61(7-8):422-427
Adolescents referred to general psychiatry services sometimes present a psychotic state occurring in the outcome of learning skills impairments existing since the early childhood, behavioural disorders and emotional disturbances. These young patients and their families are usually wandering between numerous practitioners, but very often, their questions about diagnosis remain unanswered. These patients are a real challenge for a team specialized in adult psychiatry: the therapeutic strategies are difficult to define and often poorly efficient (poor response or side effects with antipsychotics, comorbidity of learning disorders that hampers schooling as well as social and occupational reinstatement etc.). These complex “adolescents psychoses” can be viewed in the continuum of an atypical development, in order to elaborate an harmonious, consistent and efficient care program. Our close partnership with child psychiatry practitioners enables us to elaborate an original diagnostic and therapeutic approach in adult psychiatry. For these patients, we conduct a comprehensive and multidisciplinary investigation of the neurodevelopmental period – since early childhood until the emergence of the first psychotic symptoms – in an analogy with what is done in children. We present here the clinical case of a young woman for whom the semiological review of all the symptoms and the neuropsychological evaluation allowed to rethink the diagnosis since a first diagnosis of schizophrenia to a pervasive development disorder and more particularly a Gerstmann Developpemental Syndrom. The latter associates the classical tetrad of the lesional syndrome (learning calculation impairment, dysgraphia, digital agnosia and right/left indistinction) with others various learning disabilities (constructive dyspraxia, dyslexia, attention disorders etc.) and behavioural disorders. Furthermore, this integrative approach allowed thinking an adapted and efficient care program, which combined a pharmacological treatment (chlorpromazine, mirtazapine et methylphenidate), the resumption of an orthophonic program (to mitigate the linguistic and logico-mathematical difficulties), a psychomotor program and subsequently, a cognitive remediation program for dysexecutive functions done concomitantly to the construction of a psychosocial rehabilitation project. 相似文献
1000.