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51.
Psychiatric morbidity in Hobart's dependent aged 总被引:1,自引:0,他引:1
D W Kay T A Holding B Jones S Littler 《The Australian and New Zealand journal of psychiatry》1987,21(4):463-475
Psychiatric morbidity in the dependent aged was studied in the elderly population of Hobart's nursing homes and long-stay hospitals. Only patients with home addresses in Hobart and who were admitted for the first time aged 70 years or over were included. Three hundred and twelve persons were interviewed with a standard interview, and an informant was interviewed when appropriate. The medical records were searched for diagnoses and drug treatments. Physical disability was rated on an ad hoc scale. Comparisons were made of the prevalence of dementia, depression and anxiety in different types of unit, and between these and two domiciliary samples, one of which received domiciliary nursing services (n = 100) and the other not (n = 100). The differential use of institutions by men and women, and a possible sex difference in the prevalence of dementia is discussed. 相似文献
52.
Localized primary (AL) amyloid tumor of the breast. Cytologic, histologic, immunocytochemical and ultrastructural observations 总被引:2,自引:0,他引:2
J F Silverman D J Dabbs H T Norris W J Pories J Legier S Kay 《The American journal of surgical pathology》1986,10(8):539-545
Two examples of localized primary amyloid tumor of the breast are presented, including one patient with metachronous bilateral lesions. Our findings and review of the literature indicate that this rare lesion occurs predominantly in elderly females and can be mammographically and clinically confused with carcinoma. Fine-needle aspiration biopsy can be a useful procedure to make a preliminary diagnosis. Congo red staining with prior potassium permanganate incubation confirmed the AL type of amyloid in our two cases; this might be the predominant type in the localized form involving the breast. Immunofluorescence studies demonstrated IgA, with kappa and lambda light-chain deposition within the amyloid foci in one case, and intracytoplasmic IgG with both light chains within plasma cells and amyloid deposits of the second case. Ultrastructural examination of one of the cases showed characteristic findings of straight, nonbranching fibrils of 4-9 nm, diagnostic of amyloid. From our findings and a review of the literature, we conclude that amyloid tumors of the breast can occur in three separate settings: secondary amyloidosis, systemic or multiple myeloma associated amyloidosis, and as a localized primary type having a benign course. 相似文献
53.
本文用Balb/c小鼠观察了巯亚硝基蛋白在体内产生一氧化氮的量效关系,结果发现,SNO-Hb在体内可剂量信赖地产生NO。 相似文献
54.
反相高效液相色谱法测定洛氟沙星的血药浓度 总被引:7,自引:1,他引:6
采用反相HPLC法测定洛氟沙星的血药浓度,血浆样品用二氯甲烷在pH7.0条件下提取后进样,流动相为10m mol/L磷酸二氢钾-10m mol/L溴化四丁铵-乙腈-三乙胺(45:44:10:1,磷酸调节pH2.8),紫外检测器λ=295nm,最低检测浓度10μg/L,线性范围:0.1 ̄6.0mg/L,r=0.9999,日内RSD为1.38% ̄3.42%,日间RSD为1.11% ̄2.89%。 相似文献
55.
56.
在动物实验的基础上,比较了抗AFP单克隆抗体(mAb)和抗AFP多克隆抗体(pAb)两种不同抗体双弹头标记物在肝癌患者体内的生物代谢情况。结果显示,两种抗体标记物的血浆清除半衰期均在24h左右,mAb标记物的清除较pAb标记物略慢。尿清除的半衰期,mAb标记物约为120h,而pAb标记物则约为18h,表明二者的体内生物代谢不同,疗效可能不一。 相似文献
57.
1. The effect of omega-3 fatty acid supplementation on alpha 1-adrenergic receptor-mediated phosphoinositide turnover in the hearts of 6-week streptozotocin diabetic rats was studied. 2. The diabetic state was characterized by decreased body weight gain, hypoinsulinemia and hyperglycemia. Omega-3 fatty acid treatment did not have any significant effects on the above parameters. 3. Plasma triglyceride and cholesterol levels were significantly higher in diabetic rats compared with controls. 4. Omega-3 fatty acid treatment reduced the plasma triglyceride levels in the diabetic rats, whereas plasma cholesterol levels remained unaffected. 5. Norepinephrine (10 and 100 microM) stimulated inositol monophosphate (IP1) formation was significantly decreased in the diabetic rat heart compared with controls. Omega-3 fatty acid treatment had no significant effect on the norepinephrine-mediated IP1 formation in these rats. 6. Inositol bisphosphate (IP2) formation in response to 100 microM of norepinephrine was significantly lower in the diabetic rat heart; which was also not affected by omega-3 fatty acid treatment. 相似文献
58.
Ductal adenoma of the breast 总被引:1,自引:0,他引:1
Ductal adenoma is a recently described benign tumour of the breast that can be mistaken for carcinoma in both frozen and paraffin sections. Such a case is presented. Fortunately a mastectomy was not performed, but the patient did undergo axillary node dissection. Surgeons and pathologists should familiarize themselves with this lesion so that patients do not have to undergo unnecessary mastectomies and axillary node dissections. 相似文献
59.
60.
Cyclophosphamide and etoposide therapy with GM-CSF for VAD-resistant multiple myeloma 总被引:1,自引:0,他引:1
Meletios A. Dimopoulos Kay B. Delasalle Richard Champlin Raymond Alexanian 《British journal of haematology》1993,83(2):240-244
Few effective regimens are available for patients with advanced multiple myeloma resistant to or relapsing after both alkylating agents and VAD. We treated 52 patients with advanced and refractory multiple myeloma with the combination of cyclophosphamide (3.0 g/m2 ) and etoposide (900 mg/m2 ) followed by GM-CSF at a daily dose of 0.125 mg/m2 until recovery of granulocytes. 42% of patients responded with a median time of 19 d for recovery of granulocytes to 0.5 x 109 /1 and a 4% mortality rate. Eight responding patients received a second myeloablative treatment supported by either autologous bone marrow (six patients) or blood stem cells (two patients). The median survival time for all patients was 11 months and the median remission time for responding patients was 8 months. The combination of cyclophosphamide and etoposide provided an effective rescue treatment for many patients with advanced multiple myeloma resistant to conventional therapies. This programme also allowed early marrow or blood stem cell collection in support of subsequent myeloablative therapy for selected patients. 相似文献