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61.
62.
Dr. Masao Arai MD Maki Niioka BS Katsuya Maruyama MD Norihito Wada MD Noboru Fujimoto PhD Tetsu Nomiyama MD Shoutarou Tanaka MD Isao Okazaki MD 《Digestive diseases and sciences》1996,41(5):995-1000
We treated 18 patients with chronic hepatitis C by recombinant interferon-α (6 MIU for 24 weeks). In seven patients, serum aminotransferase levels declined to normal (responders). To evaluate the effect of interferon on matrix metalloproteinases (MMPs) and their inhibitors, namely tissue inhibitors of metalloproteinases (TIMPs), the serum levels of these enzymes were determined by enzyme immunoassay (EIA) using a specific monoclonal antibody. In responders, there was a tendency, but not a significant one, towards either an increase in serum MMP 1 levels or a decrease in serum TIMP 1 levels. In contrast, in nonresponders, both a significant decrease in MMP 1 and MMP 3 and a significant increase in TIMP 1 were observed. The number of cases of either increase in serum MMP levels or decrease in serum TIMP levels was significantly larger in responders than in nonresponders. Furthermore, the ratio of MMP 1 to TIMP 1 significantly increased in responders, suggesting that the balance between matrix formation and degradation in hepatic fibrosis tended to move toward degradation. These data indicate that interferon may exert a beneficial effect on hepatic fibrosis in parallel with improvement of aminotransferase activity. 相似文献
63.
64.
Shinji Naganawa Rintaro Ito Yutaka Kato Hisashi Kawai Toshiaki Taoka Tadao Yoshida Katsuya Maruyama Katsutoshi Murata Gregor Krzdrfer Josef Pfeuffer Mathias Nittka Michihiko Sone 《Magnetic resonance in medical sciences》2021,20(1):91
Purpose:To evaluate the feasibility for the detection of slight contrast effects after intravenous administration of single dose gadolinium-based contrast agent (IV-SD-GBCA), the time course of the GBCA distribution up to 24 h was examined in various fluid spaces and brain parenchyma using 3D-real IR imaging and MR fingerprinting (MRF).Methods:Twenty-four patients with a suspicion of endolymphatic hydrops were scanned at pre-administration and at 10 min, 4 and 24 h post-IV-SD-GBCA. 3D-real IR images and MRF at the level of the internal auditory canal were obtained. The signal intensity on the 3D-real IR image of the cerebrospinal fluid (CSF) in the cerebellopontine angle cistern (CPA), Sylvian fissure (Syl), lateral ventricle (LV), and cochlear perilymph (CPL) was measured. The T1 and T2 values of cerebellar gray (GM) and white matter (WM) were measured using MRF. Each averaged value at the various time points was compared using an analysis of variance.Results:The signal intensity on the 3D-real IR image in each CSF region peaked at 4 h, and was decreased significantly by 24 h (P < 0.05). All patients had a maximum signal intensity at 4 h in the CPA, and Syl. The mean CPL signal intensity peaked at 4 h and decreased significantly by 24 h (P < 0.05). All patients but two had a maximum signal intensity at 4 h. Regarding the T1 value in the cerebellar WM and GM, the T1 value at 10 min post-IV-GBCA was significantly decreased compared to the pre-contrast scan, but no significant difference was observed at the other time points. There was no significant change in T2 in the gray or white matter at any of the time points.Conclusion:Time course of GBCA after IV-SD-GBCA could be evaluated by 3D-real IR imaging in CSF spaces and in the brain by MRF. 相似文献
65.
Nolan A. Huck Janelle Siliezar-Doyle Elena S. Haight Ryosuke Ishida Thomas E. Forman Shaogen Wu Huaishuang Shen Yoshinori Takemura J. David Clark Vivianne L. Tawfik 《The Journal of neuroscience》2021,41(19):4349
Complex regional pain syndrome (CRPS) is a chronic pain disorder with a clear acute-to-chronic transition. Preclinical studies demonstrate that toll-like receptor 4 (TLR4), expressed by myeloid-lineage cells, astrocytes, and neurons, mediates a sex-dependent transition to chronic pain; however, evidence is lacking on which exact TLR4-expressing cells are responsible. We used complementary pharmacologic and transgenic approaches in mice to more specifically manipulate myeloid-lineage TLR4 and outline its contribution to the transition from acute-to-chronic CRPS based on three key variables: location (peripheral vs central), timing (prevention vs treatment), and sex (male vs female). We demonstrate that systemic TLR4 antagonism is more effective at improving chronic allodynia trajectory when administered at the time of injury (early) in the tibial fracture model of CRPS in both sexes. In order to clarify the contribution of myeloid-lineage cells peripherally (macrophages) or centrally (microglia), we rigorously characterize a novel spatiotemporal transgenic mouse line, Cx3CR1-CreERT2-eYFP;TLR4fl/fl (TLR4 cKO) to specifically knock out TLR4 only in microglia and no other myeloid-lineage cells. Using this transgenic mouse, we find that early TLR4 cKO results in profound improvement in chronic, but not acute, allodynia in males, with a significant but less robust effect in females. In contrast, late TLR4 cKO results in partial improvement in allodynia in both sexes, suggesting that downstream cellular or molecular TLR4-independent events may have already been triggered. Overall, we find that the contribution of TLR4 is time- and microglia-dependent in both sexes; however, females also rely on peripheral myeloid-lineage (or other TLR4 expressing) cells to trigger chronic pain.SIGNIFICANCE STATEMENT The contribution of myeloid cell TLR4 to sex-specific pain progression remains controversial. We used complementary pharmacologic and transgenic approaches to specifically manipulate TLR4 based on three key variables: location (peripheral vs central), timing (prevention vs treatment), and sex (male vs female). We discovered that microglial TLR4 contributes to early pain progression in males, and to a lesser extent in females. We further found that maintenance of chronic pain likely occurs through myeloid TLR4-independent mechanisms in both sexes. Together, we define a more nuanced contribution of this receptor to the acute-to-chronic pain transition in a mouse model of complex regional pain syndrome. 相似文献
66.
Daisuke Tajima Takuji Nakamura Fumio Ichinose Nobuhiko Okamoto Yuko Tomonoh Keiko Uda Rie Furukawa Katsuya Tashiro Muneaki Matsuo 《Brain & development》2021,43(3):482-485
Paroxysmal abnormal eye movement in early infancy is one of the initial symptoms of glucose transporter 1 deficiency syndrome (GLUT1DS). We describe four early infants with transient hypoglycorrhachia presenting with abnormal eye movements. Their symptoms disappeared after the introduction of a ketogenic diet (KD), and their development was normal. Since no variants in SLC2A1 were detected, the CSF-to-blood glucose ratios (C/B) were re-examined, and within normal range. None of the four patients displayed recurrent symptoms after withdrawal from the KD. Because long-term KD has potential adverse effects and could affect the quality of life of patients and their families, re-examination of CSF glucose during late infancy should be considered in the case of absence of the SLC2A1 pathogenic variant. 相似文献
67.
Hideki Moriyama Mari Shimada Shuhei Yoshida Hirofumi Takemura 《Asian journal of endoscopic surgery》2021,14(1):136-139
Previous reports have described laparoscopic mesh repair for lumbar hernia due to iliac crest bone harvest, but there have been no reports of reoperation with laparoscopic mesh repair for recurrent cases after laparoscopic mesh repair. Here, we describe the case of a 72-year-old Japanese woman with lumbar hernia recurrence 6 years after laparoscopic mesh repair for lumbar hernia due to iliac crest bone harvest. We performed a successful reoperation with laparoscopic mesh repair. Laparoscopic surgery should be considered to elucidate the mechanism of recurrence, previous mesh position, and the area that must be covered to prevent recurrence again. 相似文献
68.
Koizumi Noriyuki Hanamura Yukio Nishida Kazuya Mori Atsushi Watabe Keiji Takemura Takeshi Man Alias Kassim Faizul M. Morioka Shinsuke 《Conservation Genetics Resources》2015,7(1):133-135
Conservation Genetics Resources - We have developed microsatellite DNA markers for Mesopodopsis orientalis (Tattersall 1908), a widely distributed mysid crustacean in shallow waters of the coastal... 相似文献
69.
Plasma interleukin-6 is associated with coagulation in poorly controlled patients with Type 2 diabetes. 总被引:2,自引:0,他引:2
Y Aso K Okumura N Yoshida K Tayama T Kanda I Kobayashi Y Takemura T Inukai 《Diabetic medicine》2003,20(11):930-934
AIMS: We investigated the relationship between interleukin (IL)-6 and coagulation, i.e. whether changes in the plasma IL-6 are associated with those in coagulation markers (D dimer and fibrinogen) after glycaemic control with sulphonylurea or insulin in poorly controlled patients with Type 2 diabetes. METHODS: We studied 42 patients with Type 2 diabetes, including 19 subsequently treated with sulphonylurea, 23 treated with insulin and 48 control subjects. All patients were in poor glycaemic control and were hospitalized for 3 weeks. At the beginning and end of treatment, we measured plasma concentrations of IL-6, fibrinogen, and D dimer. RESULTS: Plasma concentrations of IL-6 and D dimer were significantly higher in diabetic patients than in controls (P<0.0001 for both). In all patients with diabetes, the plasma concentration of IL-6 decreased significantly (P<0.001) after treatment. Changes in the plasma IL-6 during hospitalization were positively correlated with those in plasma D dimer and fibrinogen (r=0.664, P<0.0001; r=0.472, P=0.0042, respectively). Treatment with sulphonylurea or insulin caused a similar fall in the plasma IL-6 concentration with a concomitant decrease in the BMI and an equal improvement in glycaemia. CONCLUSIONS: In poorly controlled patients with Type 2 diabetes, plasma IL-6 concentrations were reduced significantly even by short-term metabolic control. As changes in the plasma concentrations of D dimer are related to plasma IL-6, plasma IL-6 may reflect a pro-coagulant as well as an inflammatory state in patients with Type 2 diabetes. 相似文献
70.
Takeshi Imura Yuki Nagasawa Tetsuji Inagawa Naoki Imada Hiroaki Izumi Katsuya Emoto Itaru Tani Hiroyuki Yamasaki Yuichiro Ota Shuichi Oki Tadanori Maeda Osamu Araki 《Journal of Physical Therapy Science》2015,27(5):1383-1386
[Purpose] The efficacy of diffusion tensor imaging in the prediction of motor outcomes
and activities of daily living function remains unclear. We evaluated the most appropriate
diffusion tensor parameters and methodology to determine whether the region of interest-
or tractography-based method was more useful for predicting motor outcomes and activities
of daily living function in stroke patients. [Subjects and Methods] Diffusion tensor
imaging data within 10 days after stroke onset were collected and analyzed for 25
patients. The corticospinal tract was analyzed. Fractional anisotropy, number of fibers,
and apparent diffusion coefficient were used as diffusion tensor parameters. Motor
outcomes and activities of daily living function were evaluated on the same day as
diffusion tensor imaging and at 1 month post-onset. [Results] The fractional anisotropy
value of the affected corticospinal tract significantly correlated with the motor outcome
and activities of daily living function within 10 days post-onset and at 1 month
post-onset. Tthere were no significant correlations between other diffusion tensor
parameters and motor outcomes or activities of daily living function. [Conclusion] The
fractional anisotropy value of the affected corticospinal tract obtained using the
tractography-based method was useful for predicting motor outcomes and activities of daily
living function in stroke patients.Key words: Stroke, Diffusion tensor tractography, Activities of daily living function 相似文献