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排序方式: 共有530条查询结果,搜索用时 515 毫秒
61.
Shoichi Yamagata M.D. Akira Ishimori Hachirō Satō Tetsurō Taneda Kuni Ishihara Naohumi Tōhei Masasuke Masuda Keiichi Kawai Yoshio Hara Kenkichi Konishi Shinroku Ashizawa Hachiro Nakano Sōtarō Fukuchi Haruya Okabe Kenji Tsuneoka Yasushi Saitō Tadayoshi Takemoto Kimie Kurokawa Hirohumi Niwa Eizō Kaneko Hisayuki Masuda Takeo Wada Katsumi Sato Nobuya Ogawa 《Journal of gastroenterology》1975,10(4):323-341
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Using pretest data to screen low‐reactivity individuals in the autonomic‐based concealed information test
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The concealed information test (CIT) can be used to assess whether an individual possesses crime‐related information. However, its discrimination performance has room for improvement. We examined whether screening out participants who do not respond distinctively on a pretest improves the diagnosticity of a mock‐crime CIT. Before conducting the CIT, we gave a pretest to 152 participants, 80 of whom were assigned as guilty. Pretest screening significantly improved the diagnostic value of the mock‐crime CIT; however, it also led to a substantial number of undiagnosed participants (33.6%). Pretest screening holds promise, but its application would benefit from dedicated measures for screening out participants. 相似文献
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Rat erythrocytes, separated from other blood cells by SE-cellulose chromatography, were lysed by exposure to hypotonic solution, dialyzed and ultracentrifuged. The supernatant contained a substance which enhanced the activity of colony stimulating factor (CSF) in soft agar cultures of granulocyte-macrophage progenitor cells (CFU-C) from normal mouse bone marrow. The growth-enhancing effect of the erythrocyte factor was observed when mouse L-cell conditioned medium was used as the CSF source and also when serum from endotoxin-treated mice or from mice undergoing graft-versus-host reaction was used as the stimulant. The erythrocyte factor effect was also detected by 3H-thymidine uptake of bone marrow cells in liquid cultures. These results suggest that the effect of the erythrocyte factor on CSF is not restricted to CSF from a specific source nor to semi-solid agar cultures. 相似文献
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Ken Kitahara Yuji Nakamura Yayoi Tsuneoka Satomi Adachi-Akahane Hikaru Tanaka Hiroshi Yamazaki Akira Takahara Junichi Yamazaki Takanori Ikeda Atsushi Sugiyama 《Cardiovascular toxicology》2013,13(3):234-243
Electropharmacological effects of oseltamivir were studied in comparison with pilsicainide using halothane-anesthetized dogs (n = 4) and isolated left atrium of guinea pigs (n = 5). Oseltamivir (0.3, 3 and 30 mg/kg, i.v.) or pilsicainide (1 and 3 mg/kg, i.v.) was additionally administered to the dogs. The low dose of oseltamivir provided clinically relevant plasma concentrations with C max of 4 μM. The low and middle doses of oseltamivir increased cardiac output, whereas the middle dose increased blood pressure and delayed intra-atrial conduction and ventricular repolarization. The high dose of oseltamivir exerted negative chronotropic, inotropic and hypotensive effects, while it delayed intra-atrial, atrioventricular nodal and intra-ventricular conduction and ventricular repolarization. Use-dependent delay of ventricular repolarization was observed after oseltamivir, whereas reverse use-dependent prolongation was induced by pilsicainide. Moreover, oseltamivir more selectively suppressed intra-atrial conduction than intra-ventricular conduction, which was less selective for pilsicainide. Action potential assay using isolated atrium indicated that oseltamivir (10 μM) decreased V max more than pilsicainide (10 μM) and that oseltamivir (10–100 μM) prolonged action potential duration, which was not induced by pilsicainide (1–10 μM). Thus, oseltamivir in clinically relevant to its 10 times higher doses is relatively safe, whereas 10–100 times higher doses possess unique electrophysiological profile. 相似文献
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Shin-ichi Yamashita Yoshio Haga Etsuo Nemoto Naoko Imanishi Morio Ohta Katsunobu Kawahara 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2006,54(9):391-395
OBJECTIVE: The purpose of this study was to determine if our predictive scoring system, E-PASS, can estimate the surgical outcome. METHODS: We conducted a multicenter cohort study for 3 years in four national hospitals. A consecutive series of 731 patients who underwent elective thoracic operations were analyzed. The preoperative risk score (PRS) and the comprehensive risk score (CRS) of the E-PASS were determined preoperatively and immediately after the operation, respectively. The cost of the surgical admission and the severity of the postoperative complications were recorded at the time of discharge. RESULTS: The CRS significantly correlated with the severity of the postoperative complications (rs = 0.728, P < 0.0001) and the charge (rs = 0.530, P< 0.0001). When the estimated/real morbidity ratio (MR) among the hospitals was compared, it varied from 0.16 to 0.59. A significant increase in the cost was observed according to the CRS. CONCLUSION: The E-PASS scoring system may be useful for standardizing the patient population and surgical severity to compare the surgical outcome. 相似文献