收费全文 | 2417篇 |
免费 | 155篇 |
国内免费 | 3篇 |
耳鼻咽喉 | 16篇 |
儿科学 | 51篇 |
妇产科学 | 18篇 |
基础医学 | 414篇 |
口腔科学 | 67篇 |
临床医学 | 187篇 |
内科学 | 505篇 |
皮肤病学 | 46篇 |
神经病学 | 254篇 |
特种医学 | 51篇 |
外科学 | 303篇 |
综合类 | 3篇 |
预防医学 | 187篇 |
眼科学 | 20篇 |
药学 | 197篇 |
中国医学 | 6篇 |
肿瘤学 | 250篇 |
2024年 | 2篇 |
2023年 | 24篇 |
2022年 | 51篇 |
2021年 | 70篇 |
2020年 | 36篇 |
2019年 | 82篇 |
2018年 | 80篇 |
2017年 | 51篇 |
2016年 | 55篇 |
2015年 | 100篇 |
2014年 | 102篇 |
2013年 | 150篇 |
2012年 | 204篇 |
2011年 | 224篇 |
2010年 | 111篇 |
2009年 | 130篇 |
2008年 | 182篇 |
2007年 | 176篇 |
2006年 | 156篇 |
2005年 | 155篇 |
2004年 | 139篇 |
2003年 | 119篇 |
2002年 | 73篇 |
2001年 | 11篇 |
2000年 | 9篇 |
1999年 | 19篇 |
1998年 | 18篇 |
1997年 | 10篇 |
1996年 | 4篇 |
1995年 | 5篇 |
1994年 | 4篇 |
1993年 | 2篇 |
1992年 | 5篇 |
1991年 | 2篇 |
1990年 | 2篇 |
1987年 | 1篇 |
1985年 | 3篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1981年 | 3篇 |
1977年 | 1篇 |
1976年 | 1篇 |
Purpose
Extended-duration thromboprophylaxis (EDTPPX) is the practice of prescribing antithrombotic therapy for 21 days after discharge, commonly used in surgical patients who are at high risk for venothromboembolism (VTE). While guidelines recommend EDTPPX, criteria are vague due to a paucity of data. The criteria can be further informed by cost-effectiveness thresholds. This study sought to determine the VTE incidence threshold for the cost-effectiveness of EDTPPX compared to inpatient prophylaxis.Methods
A decision tree was used to compare EDTPPX for 21 days after discharge to 7 days of inpatient prophylaxis with base case assumptions based on an abdominal oncologic resection without complications in an otherwise healthy individual. Willingness to pay was set at $50,000/quality-adjusted life year (QALY). Sensitivity analyses were performed to assess uncertainty within the model, with particular interest in the threshold for cost-effectiveness based on VTE incidence.Results
EDTPPX was the dominant strategy when VTE probability exceeds 2.39 %. Given a willingness to pay threshold of $50,000/QALY, EDTPPX was the preferred strategy when VTE incidence exceeded 1.22 and 0.88 % when using brand name or generic medication costs, respectively.Conclusions
EDTPPX should be recommended whenever VTE incidence exceeds 2.39 %. When post-discharge estimated VTE risk is 0.88–2.39 %, patient preferences about self-injections and medication costs should be considered. 相似文献Introduction
Mainly due to the high percentage of infection and the ineffectiveness of treatments, Helicobacter pylori is a global health problem. Knowing the age at acquisition is key to preventing the infection.Patients
Sixty-seven mothers and their respective children participated. To evaluate the presence of H. pylori, the faeces of the mother and her child were analysed using the HpSA antigen test.Results
71.6% (48/67) of pregnant mothers were positive for H. pylori at the term of their pregnancy. In newborns, 8.96% (6/67) of them showed H. pylori colonisation/persistent infection. During the first month of life, a prevalence and incidence of infection of 23.9% and 13%, respectively, was observed.Conclusion
Overall, the results suggest that there is a high risk of H. pylori infection during the first month of life, even of the persistent type. 相似文献Median age at diagnosis of lung cancer is 70 years. Its presentation in patients 40 or younger is uncommon and it has been proposed that maybe it is a different disease due to its clinical characteristics and genetic makeup. There are a limited number of studies in this population and they report different clinic-pathological characteristics in comparison with older patients.
MethodsWe described the incidence of lung cancer patients diagnosed at age 40 or younger at the Instituto Nacional de Enfermedades Neoplasicas (INEN), Lima-Peru; from 2009 to 2017 and evaluated the characteristic of NSCLC. Epidemiologic and clinic-pathological data was collected from clinical files. Analysis was carried out using SPSSvs19 software.
ResultsWe identified 3823 patients with lung cancer seen at INEN during the study period. Among these, 166 (4.3%) patients were 40 years or younger, and 137/166 (82.5%) were NSCLC. Median age at diagnosis was 36 years (range 14–40 years) and 59.1% of patients were female. A smoking history was present in 14.4% of patients. Frequent symptoms at diagnosis were cough (62.0%), chest pain (51.8%) and dyspnea (40.9%). Adenocarcinoma was the most common histological type (63.3%). Most patients had advanced disease at diagnosis (84.7%). The median overall survival was 8.2 months.
ConclusionsThe proportion of young patients with lung cancer in our population is higher than that reported in the most recent literature. Lung cancer in the young is mostly sporadic, more frequent in women, usually adenocarcinoma type and it presents with advanced disease, resulting in a very poor survival.
相似文献