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排序方式: 共有5928条查询结果,搜索用时 78 毫秒
141.
Benoit Peyronnet Emmanuel Oger Zineddine Khene Gregory Verhoest Romain Mathieu Mathieu Roumiguié Jean-Baptiste Beauval Benjamin Pradere Alexandra Masson-Lecomte Christophe Vaessen Hervé Baumert Jean-Christophe Bernhard Nicolas Doumerc Stéphane Droupy Franck Bruyere Alexandre De La Taille Morgan Roupret Karim Bensalah 《World journal of urology》2015,33(11):1815-1820
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Laurence Ladrière Karim Louchami Aouatif Laghmich Francine Malaisse-Lagae Willy J. Malaisse 《Endocrine》2001,14(3):383-397
Under conditions of sustained hyperglycemia, glycogen accumulates in pancreatic islets, but not so in acinar pancreatic cells.
We investigated whether advantage could be taken of such a situation in the perspective of the noninvasive imaging of the
endocrine pancreas. Control rats or animals injected with streptozotocin (STZ) were infused with solutions of d-glucose mixed with a tracer amount of d-[U-14C]glucose, and the radio-active glycogen content of both liver and pancreas was then measured. After 48 h of infusion, the
radio-active glycogen content of the pancreas was 30 times lower in STZ rats than in control animals, coinciding with a 50
times lower insulin content. In the control rats, a sizable labeling of pancreatic glycogen was also recorded when d-[U-14C]glucose was infused for only the last 4 h of unlabeled d-glucose infusion; such a labeling was not decreased when the animals were further infused for 1 h with only the unlabeled
hexose. Moreover, a pronounced difference in the pancreatic gland and blood radioactive content of control rats was still
observed when the hyperglycemic animals were killed only 40 min after the iv injection of d-[U-14C]glucose. In STZ rats transplanted with islets and later infused with d-[U-14C]glucose, the total radioactive content and radioactive glycogen content were both much higher in the transplanted islets
than in the pancreatic gland. These results allow one to define the conditions under which the administration of either 2-deoxy-2-[18F]fluoro-d-glucose or 11C-labeled d-glucose could conceivably be used to favor the selective labeling of the endocrine, as distinct from exocrine, pancreas. 相似文献
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Thierry Boulain Julie Boisrame-Helms Stephan Ehrmann Jean-Baptiste Lascarrou Adrien Bouglé Arnaud Chiche Karim Lakhal Stéphane Gaudry Sébastien Perbet Arnaud Desachy Séverin Cabasson Isabelle Geneau Patricia Courouble Noémie Clavieras Pablo L. Massanet Frédéric Bellec Yoan Falquet François Réminiac Philippe Vignon Pierre-François Dequin Ferhat Meziani 《Intensive care medicine》2015,41(2):248-256
150.
Karim R. Saab Jessica Kendrick Joseph M. Yracheta Miguel A. Lanaspa Maisha Pollard Richard J. Johnson 《Journal of the American Society of Nephrology : JASN》2015,26(2):247-257
African Americans are at increased risk for cardiovascular and metabolic diseases, including obesity, high BP, diabetes, CKD, myocardial infarction, and stroke. Here we summarize the current risks and provide an overview of the underlying risk factors that may account for these associations. By reviewing the relationship between cardiovascular and renal diseases and the African-American population during the early 20th century, the historic and recent associations of African heritage with cardiovascular disease, and modern population genetics, it is possible to assemble strong hypotheses for the primary underlying mechanisms driving the increased frequency of disease in African Americans. Our studies suggest that underlying genetic mechanisms may be responsible for the increased frequency of high BP and kidney disease in African Americans, with particular emphasis on the role of APOL1 polymorphisms in causing kidney disease. In contrast, the Western diet, particularly the relatively high intake of fructose-containing sugars and sweetened beverages, appears to be the dominant force driving the increased risk of diabetes, obesity, and downstream complications. Given that intake of added sugars is a remediable risk factor, we recommend clinical trials to examine the reduction of sweetened beverages as a primary means for reducing cardiovascular risk in African Americans. 相似文献