全文获取类型
收费全文 | 69106篇 |
免费 | 5183篇 |
国内免费 | 267篇 |
专业分类
耳鼻咽喉 | 760篇 |
儿科学 | 2493篇 |
妇产科学 | 1639篇 |
基础医学 | 8301篇 |
口腔科学 | 1100篇 |
临床医学 | 9315篇 |
内科学 | 13158篇 |
皮肤病学 | 944篇 |
神经病学 | 6088篇 |
特种医学 | 1789篇 |
外国民族医学 | 1篇 |
外科学 | 8208篇 |
综合类 | 1156篇 |
一般理论 | 63篇 |
预防医学 | 7477篇 |
眼科学 | 1702篇 |
药学 | 4650篇 |
1篇 | |
中国医学 | 175篇 |
肿瘤学 | 5536篇 |
出版年
2023年 | 478篇 |
2022年 | 652篇 |
2021年 | 1567篇 |
2020年 | 1062篇 |
2019年 | 1614篇 |
2018年 | 1876篇 |
2017年 | 1368篇 |
2016年 | 1497篇 |
2015年 | 1678篇 |
2014年 | 2339篇 |
2013年 | 3276篇 |
2012年 | 4995篇 |
2011年 | 5216篇 |
2010年 | 2873篇 |
2009年 | 2563篇 |
2008年 | 4546篇 |
2007年 | 4502篇 |
2006年 | 4320篇 |
2005年 | 4205篇 |
2004年 | 3996篇 |
2003年 | 3544篇 |
2002年 | 3312篇 |
2001年 | 1363篇 |
2000年 | 1221篇 |
1999年 | 1142篇 |
1998年 | 738篇 |
1997年 | 573篇 |
1996年 | 472篇 |
1995年 | 420篇 |
1994年 | 404篇 |
1993年 | 376篇 |
1992年 | 641篇 |
1991年 | 594篇 |
1990年 | 530篇 |
1989年 | 501篇 |
1988年 | 452篇 |
1987年 | 415篇 |
1986年 | 414篇 |
1985年 | 408篇 |
1984年 | 321篇 |
1983年 | 282篇 |
1982年 | 230篇 |
1981年 | 204篇 |
1980年 | 181篇 |
1979年 | 202篇 |
1978年 | 124篇 |
1977年 | 141篇 |
1976年 | 91篇 |
1975年 | 85篇 |
1974年 | 101篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
Fix Joseph A. Alexander Jose Cortese Margot Engle Karen Leppert Paula Repta A. J. 《Pharmaceutical research》1990,7(4):384-387
Short-chain alkyl esters of L-dopa were administered to rats and mice via oral and rectal routes. Plasma L-dopa esters and L-dopa were determined in the systemic and portal circulation by HPLC. A comparison of isopropyl, butyl, and 4-hydroxybutyl esters of L-dopa demonstrated significantly higher levels of the esters in both systemic and portal blood samples following rectal administration than following oral administration. In most cases, oral administration resulted in nondetectable (<0.01 µg/ml) levels of the esters in plasma. Correspondingly, the plasma levels of L-dopa itself were consistently higher following rectal administration. At very high oral doses (500 mg L-dopa equivalents/kg body weight), systemic plasma levels of the butyl ester could be detected (1.25 µg/ml at 10 min), which might indicate saturation of the esterase activity of the small intestine. These studies indicate that the systemic availability of L-dopa from short-chain alkyl esters of L-dopa may be best optimized by rectal administration, which avoids the relatively high esterase activity characteristic of the small intestine. 相似文献
102.
Diagnosis of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes in a Chinese family by PCR/restriction enzyme analysis 总被引:1,自引:0,他引:1
下载免费PDF全文
![点击此处可从《Journal of clinical pathology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
C W Lam K Jain K Y Chan D K Silva Y W Chan L J C Wong 《Journal of clinical pathology》1995,48(5):M285-M288
The clinical presentation and the biochemical and molecular genetic findings are described in a 13 year old Chinese boy with MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes). The diagnosis was initially suspected because of the characteristic clinical features and the strong family history of convulsions. Using polymerase chain reaction—restriction enzyme analysis, the heteroplasmic nt3243 A→G mutation in mtDNA of peripheral blood leucocytes and a muscle sample was demonstrated. The oligosymptomatic relatives were then screened by this method and the degree of heteroplasmy was analysed. This appears to be the first report of a MELAS family in Hong Kong with this described mutation. Molecular genetic techniques are advantageous in the diagnosis of MELAS. 相似文献
103.
W W Wong W J Cochran W J Klish E O Smith L S Lee M L Fiorotto P D Klein 《European journal of clinical nutrition》1988,42(3):233-242
We estimated body fat in 20 normal adults (10 males and 10 females) from 18O- and 2H-dilution spaces and from the equations of Durnin & Womersley and Pollock, Schmidt & Jackson based on skinfold thickness measurements. Differences between methods for body fat estimation were found to be sex-dependent: subsequent analyses indicated significant differences between methods within each sex. Regardless of sex, the highest fat estimates were obtained with the 18O-dilution method, followed by those obtained with the 2H-dilution method or the Durnin & Womersley equation. The lowest fat estimates were obtained using the Pollock, Schmidt & Jackson equation. The 18O-dilution method and the Durnin & Wormersley anthropometric method are both suitable and appropriate for body fat estimation in adults studied under field conditions. 相似文献
104.
105.
Walter F. McKeever Karen S. Seitz Annette J. Krutsch Patti L. Van Eys 《Neuropsychologia》1995,33(12):1627-1635
Rasmussen and Milner [N.Y. Acad. Sci. Vol. 299, pp. 355–379, 1977] published data on late-lesioned (after age 6) epileptic patients who had suffered left hemisphere lesions. They estimated that left hemisphere dominance occurred in 96% of dextrals and 70% of sinistrals. These figures have been regarded as valid estimates for normal dextrals and sinistrals. We administered the Bilateral Object Naming Latency Task, a verbal tachistoscopic task with very good psychometric properties, to 188 dextral and 72 sinistral normals. Results showed that 93.6% of the dextrals and 80.3% of the sinistrals were left hemisphere dominant. A consideration of results from a number of carefully conducted dichotic listening studies suggests, as do present results, that the 70% left-dominance estimate of Rasmussen and Milner for normal sinistrals may be too low by about 10%. It is suggested that ‘bilateral dominance’, present in 15% of the epileptic sinistrals of Rasmussen and Milner, may be much less common in normal sinistrals. 相似文献
106.
107.
本实验研究血液与非血液灌流条件下缺血预处理(IP)对心肌的保护作用。应用离体大鼠Langendorf灌流模型,分血液灌流IP组、非血液(KrebsHenseleit液,KH液)灌流IP组及相应的对照组。测量心肌电生理特性等指标。结果与KH液灌流心脏相似,用血液灌流的大鼠心脏经IP后,在随后的停灌和复灌期间,心室颤动阈升高,心律失常发生率明显降低。实验结论为在用血液灌流离体大鼠心脏模型上,IP对心肌的保护作用与用生理溶液灌流的模型基本相同。 相似文献
108.
The doubly labelled water method was used to estimate energy expenditure in 20 formula-fed infants (10 aged 1 month and 10 aged 4 months). We then compared the energy expenditure values with energy balance values calculated from energy intake and energy cost of growth. Our purpose was to compare various published equations for calculating CO2 expiration rates (and thus energy expenditure values) from the isotopic data. Those equations in which we used measured values for 18O and 2H isotope dilution spaces and estimated or measured values for insensible water losses yielded energy expenditure values (69.7 +/- 8.4 kcal/kg/d) that agreed most closely with energy balance data (70.3 +/- 11.9 kcal/kg/d). Equations in which we used a constant ratio of 1.03 between the 2H and 18O isotope dilution spaces resulted in energy expenditure values (66.3 +/- 10.2 kcal/kg/d) lower than those predicted by the energy balance data. Data analysis by nonlinear curve fitting compared to logarithmic transformation did not alter the estimates of energy expenditure obtained in these infants. 相似文献
109.
S G Wong 《Journal of the American Optometric Association》1988,59(8):594-597
For a number of years, optometrists have had informal working and referral relationships with many hospitals. Many hospitals were requesting diagnostic and treatment services from community optometrists while many optometrists were also requesting official recognition. With changes in the medical staff standard of the Joint Commission on Accreditation of Hospitals (JCAH)a that allowed independently licensed practitioners to be on staff, a number of optometrists have been requesting clinical privileges and to be on the Medical Staff. Practicing in a hospital can augment one's practice and can allow the optometrist greater opportunities to interact with other professionals and utilize the hospital's diagnostic facilities. 相似文献
110.