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991.
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993.
Bharti Uma Sharma Eshan Parihar Jyoti Sharma Namrata 《Proceedings of the National Academy of Sciences, India. Section B.》2019,89(4):1373-1378
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences - Artemisia maritima L., a potent source of Santonin (a drug used to expel roundworms), forms isolated... 相似文献
994.
Chowdhary Kanika Kaushik Nutan 《Proceedings of the National Academy of Sciences, India. Section B.》2019,89(4):1379-1387
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences - Microbial biopesticides offer an eco-friendly alternative to synthetic chemical pesticides. Bioassay-guided... 相似文献
995.
Dey D Medicherla S Neogi P Gowri M Cheng J Gross C Sharma SD Reaven GM Nag B 《Metabolism: clinical and experimental》2003,52(8):1012-1018
Agonists of the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR gamma) are pharmacologically active antihyperglycemic agents that act by increasing peripheral tissue sensitivity to insulin. Many of these agonists have antihyperglycemic activity that is directly proportional to their ability to bind and activate PPAR gamma; however, recent data bring this relationship into question. In this report we describe a new PPAR gamma agonist, CLX-0921, that is derived from a natural product. This thiazolidinedione (TZD) has a spectrum of activity that differs from commercially available TZDs. It is a weak activator of PPAR gamma (EC(50) of 0.284 micromol/L) compared to rosiglitazone (EC(50) 0.009 micromol/L). Despite this difference, the drug maintains potent glucose uptake activity in vitro and glucose-lowering activity in vivo that is equipotent to that of rosiglitazone. Moreover, CLX-0921 showed a 10-fold reduction in in vitro adipogenic potential compared to rosiglitazone. CLX-0921 also increases glycogen synthesis, an activity not typically associated with rosiglitazone or pioglitazone. Thus CLX-0921 appears to have a distinct spectrum of activity relative to other TZDs. 相似文献
996.
Mahajan VK Sharma NL Sharma RC 《International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association》2004,72(4):473-479
Lupus vulgaris is a variant of cutaneous tuberculosis. Its more destructive and mutilating clinical forms have become rarer in consonance of a general decline of cutaneous tuberculosis. It is rarely seen now in developed countries due to stringent control measures, improved quality of living and effective therapeutic regimens. Misdiagnosis, neglect, or late diagnosis may result in severe, ulcerative and mutilating "wolf eaten" skin lesions.This paper describes four such cases of "were-wolf" cutaneous tuberculosis. Early diagnosis and treatment is important to prevent much of the disfigurement. 相似文献
997.
Anomalous origin of the left pulmonary artery from the ascending aorta in a patient with tetralogy of Fallot and "absent pulmonary valve". 总被引:1,自引:0,他引:1
The rare association of tetralogy of Fallot, rudimentary formation of the leaflets of the pulmonary valve, and anomalous origin of the left pulmonary artery from the ascending aorta is described in a two-month-old infant. The diagnosis was made by cardiac catheterisation and angiography. 相似文献
998.
Immunopathologic and clinical studies in pulmonary hypertension associated with systemic lupus erythematosus 总被引:6,自引:0,他引:6
Francisco P. Quismorio Jr. M.D. Professor of Medicine Om Sharma M.D. Associate Professor of Medicine Michael Koss M.D. Associate Professor of Pathology Thomas Boylen M.D. Professor of Medicine Allen W. Edmiston M.D. Associate Professor of Medicine Phyllis J. Thornton M.D. Clinical Instructor Dorothy Tatter M.D. Associate Professor of Pathology 《Seminars in arthritis and rheumatism》1984,13(4):349-359
PH is an uncommon manifestation of SLE. The symptoms of PH develop within a few years after the onset of the multisystem disease. The most common presenting complaints of SLE patients with PH are dyspnea on exertion, chest pain, nonproductive cough, edema, and fatigue or weakness. The important physical findings are a loud second pulmonic heart sound and a right ventricular lift. The chest roentgenogram shows a cardiomegaly, a prominent pulmonary segment, and usually clear lung fields. Pulmonary function tests may show evidence of restrictive lung disease; however, the physiologic abnormalities are mild and out of proportion to the severity of the PH. The diagnosis of PH is established by cardiac catheterization showing elevated pulmonary artery pressure, normal capillary wedge pressure, and no evidence of intracardiac or extracardiac shunts. Pathologic examination of the lung demonstrates angiomatoid lesions involving muscular pulmonary arteries. There is a thickening of the media and subintima of the arterioles. Immunoglobulin and complement deposits are found in the walls of pulmonary arteries. Immunoglobulin eluted from the lung contains rheumatoid factor and antinuclear antibody including antibody to DNA activity. DNA antigen is also present in walls of blood vessels. These results suggest an immune complex deposition process as a mechanism in the pathogenesis of PH in SLE. The clinical course of PH in SLE is variable. Symptoms may be mild and the disease follows a stable and protracted course for several years. It can, however, develop a progressive course ending in death in a few years. The clinical response of SLE patients with PH to treatment with high doses of systemic corticosteroids is not consistent or predictable. 相似文献
999.
During the last 25 years, 20 patients with cirrhosis of liver with severe cyanosis and gross clubbing simulating congenital cyanotic heart disease were subjected to cardiac catheterization and angiography, splenography, liver function tests, and liver biopsy. No portopulmonary fistulas could be demonstrated. The cyanosis and clubbing were secondary to right to left intrapulmonary shunting across multiple tiny pulmonary arteriovenous fistulas. In 15 cases, selective pulmonary angiography revealed discrete arteriovenous fistulas. In five cases, the angiogram did not reveal any convincing evidence of pulmonary arteriovenous fistulas. In two of these five cases, peripheral vein contrast echocardiography demonstrated right to left intrapulmonary shunting and seems a sensitive investigation. Open lung biopsy in one case showed evidence of pulmonary arteriovenous fistulas. 相似文献
1000.
Shiv Kumar Sarin Ashish Kumar Yogesh Kumar Chawla Sanjay Saran Baijal Radha Krishna Dhiman Wasim Jafri Laurentius A Lesmana Debendranath Guha Mazumder Masao Omata Huma Qureshi Rizvi Moattar Raza Peush Sahni Puja Sakhuja Mohammad Salih Amal Santra Barjesh Chander Sharma Praveen Sharma Gamal Shiha Jose Sollano 《Hepatology International》2007,1(3):398-413
The Asian Pacific Association for the Study of the Liver (APASL) Working Party on Portal Hypertension has developed consensus
guidelines on the disease profile, diagnosis, and management of noncirrhotic portal fibrosis and idiopathic portal hypertension.
The consensus statements, prepared and deliberated at length by the experts in this field, were presented at the annual meeting
of the APASL at Kyoto in March 2007. This article includes the statements approved by the APASL along with brief backgrounds
of various aspects of the disease. 相似文献