全文获取类型
收费全文 | 2210篇 |
免费 | 154篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 31篇 |
儿科学 | 34篇 |
妇产科学 | 64篇 |
基础医学 | 241篇 |
口腔科学 | 27篇 |
临床医学 | 215篇 |
内科学 | 400篇 |
皮肤病学 | 34篇 |
神经病学 | 160篇 |
特种医学 | 137篇 |
外科学 | 314篇 |
综合类 | 78篇 |
一般理论 | 2篇 |
预防医学 | 273篇 |
眼科学 | 23篇 |
药学 | 189篇 |
中国医学 | 9篇 |
肿瘤学 | 139篇 |
出版年
2023年 | 12篇 |
2022年 | 24篇 |
2021年 | 71篇 |
2020年 | 43篇 |
2019年 | 72篇 |
2018年 | 104篇 |
2017年 | 62篇 |
2016年 | 50篇 |
2015年 | 58篇 |
2014年 | 67篇 |
2013年 | 97篇 |
2012年 | 147篇 |
2011年 | 161篇 |
2010年 | 77篇 |
2009年 | 68篇 |
2008年 | 112篇 |
2007年 | 103篇 |
2006年 | 114篇 |
2005年 | 127篇 |
2004年 | 109篇 |
2003年 | 102篇 |
2002年 | 93篇 |
2001年 | 39篇 |
2000年 | 38篇 |
1999年 | 35篇 |
1998年 | 15篇 |
1997年 | 12篇 |
1996年 | 7篇 |
1995年 | 13篇 |
1994年 | 13篇 |
1993年 | 12篇 |
1992年 | 26篇 |
1991年 | 21篇 |
1990年 | 38篇 |
1989年 | 22篇 |
1988年 | 18篇 |
1987年 | 16篇 |
1986年 | 17篇 |
1985年 | 7篇 |
1984年 | 7篇 |
1979年 | 12篇 |
1978年 | 9篇 |
1975年 | 8篇 |
1974年 | 10篇 |
1973年 | 11篇 |
1972年 | 9篇 |
1969年 | 9篇 |
1968年 | 11篇 |
1966年 | 13篇 |
1965年 | 6篇 |
排序方式: 共有2370条查询结果,搜索用时 62 毫秒
51.
52.
Hassine E Bousnina S Marniche K Fennira H Ben Khelil J Ben Mustapha MA Megdiche ML Chabbou A 《Annales de médecine interne》2002,153(3):147-152
Pulmonary involvement in Beh?et's disease is an uncommon condition (12%). Thromboembolism of the superior vena cava and/or other mediastinal veins, aneurysms of the aorta and pulmonary arteries are the main vascular manifestations in addition to pulmonary infarct and intrathoracic hemorrhage. Despite their scarcity, respiratory symptoms may be life-threatening. The aim of this study was to assess the contribution of thoracic imaging for one of the most serious aspects of the disease: pulmonary artery aneurysm. We report five patients with pulmonary artery aneurysms (mean age: 39.5 years). Hemoptysia revealed Beh?et's disease in three. Initially explored by conventional radiography, computed tomography and angiography, pulmonary artery aneurysms are currently investigated well with helicoidal computed tomography, digital angiography, magnetic resonance imaging (MRI) and angio-MRI. These imaging techniques provide helpful information for the diagnosis of Beh?et's disease. 相似文献
53.
Jared A White David T Redden Mary Kate Bryant David Dorn Souheil Saddekni Ahmed Kamel Abdel Aal Jessica Zarzour David Bolus J Kevin Smith Stephen Gray Devin E Eckhoff Derek A DuBay 《HPB : the official journal of the International Hepato Pancreato Biliary Association》2014,16(12):1095-1101
ObjectivesRepeat transarterial chemoembolization (TACE) is a common intervention performed for hepatocellular carcinoma (HCC). The aim of this study was to identify predictors of the need for repeat TACE.MethodsBetween 2008 and 2012, data on patient and tumour variables were collected for 262 patients treated with a first TACE procedure for HCC. The decision to perform repeat TACE procedures was made at the completion of the first TACE or after follow-up imaging demonstrated the subtotal treatment of HCC tumours.ResultsRepeat TACE was performed in 67 of 262 (25.6%) patients. Necrosis of HCC, measured after the first TACE, was lower in patients who subsequently received repeat TACE (P = 0.042). On multivariable analysis, total tumour diameter of >5 cm [odds ratio (OR) 2.76, 95% confidence interval (CI) 1.45–5.25; P = 0.002] and increasing age (OR 1.04/year, 95% CI 1.00–1.07; P = 0.030) were predictive of the need for repeat TACE. Measures of liver function and TACE approach (selective versus non-selective) were not predictive of repeat TACE. Median survival did not differ significantly between patients who did (median survival: 21.1 months) and did not (median survival: 26.1 months) receive a repeat TACE procedure (P = 0.574).ConclusionsThe requirement for repeat TACE is associated with older age, increased HCC tumour burden and subtotal TACE-induced HCC necrosis. Importantly, repeat TACE was not associated with reduced survival. 相似文献
54.
55.
Rehab H. Abd El‐Aleam Riham F. George Kevin J. Lee Adam B. Keeton Gary A. Piazza Amr A. Kamel Mahmoud E. El‐Daly Ghaneya S. Hassan Hamdy M. Abdel‐Rahman 《Archiv der Pharmazie》2019,352(8)
A series of 1,2,4‐triazolo[1,5‐a]pyrimidine derivatives was designed, synthesized, and screened for their phosphodiesterase (PDE 4B) inhibitory activity and bronchodilation ability. Compound 7e showed 41.80% PDE 4B inhibition at 10 µM. Eight compounds were screened for their bronchodilator activity, where compounds 7f and 7e elicited promising bronchodilator activity with EC50 values of 18.6 and 57.1 µM, respectively, compared to theophylline (EC50 = 425 µM). Molecular docking at the PDE 4B active site revealed a binding mode and docking scores comparable to those of a reference ligand, consistent with their PDE 4B inhibition activity. 相似文献
56.
Abdou S. Ellabban Shereen R. Kamel Hanaa A. S. Abo Omar Ashraf M. H. El-Sherif Rasha A. Abdel-Magied 《Rheumatology international》2012,32(12):3863-3868
To investigate the role of high-frequency ultrasonography in the diagnosis of calcium pyrophosphate dihydrate (CPPD) calcifications, in the most commonly affected joints in CPPD disease. Sixty patients with knee effusion were included in the study. All patients underwent musculoskeletal ultrasonography (on the shoulder, elbow, wrist, and knee joints), radiological examination of the sites examined by US, and synovial fluid analysis (using polarized light microscopy). Out of 60 patients with knee effusion, ultrasonographic calcifications (knees, shoulders, and wrists) were present in 38 patients (63.3%) and out of those patients; 32 had calcification characteristic of CPPD crystals deposition (hyperechoic deposits) in the knee and wrist joints. Pattern II (punctate pattern) was the most common pattern of calcification. It was present in all patients who had wrist calcification (18 patients) and in the knee in either alone (21 patients) or in association with pattern I (hyperechoic band) and/or pattern III (hyperechoic nodular or oval deposits) (9 patients). The sensitivity of ultrasonography for the detection of calcification was 84.2% while that of plain radiography was 13.2%, the specificity of both ultrasonography and plain radiography for the detection of calcification was 100%, and ultrasonography is valuable for diagnosing articular chondrocalcinosis via the detection of calcifications within the joint cartilage and fibrocartilage. Both sensitivity and specificity are high for detecting CPPD deposits. 相似文献
57.
Joshi D Bicer EI Donmez C Hsiung MC Nanda NC Sadat K Sudhakar S Ibrahim H Pandey A Karia N Bhagatwala K Yin WH Jeng-Wei Chung-Yi-Chang Chung YC Tsai SK Dumaswala B Dumaswala K 《Echocardiography (Mount Kisco, N.Y.)》2012,29(5):620-630
We compared findings from intraoperative live/real time three-dimensional transesophageal echocardiography (3DTEE) and two-dimensional transesophageal echocardiography (2DTEE) with surgery in 67 patients having aortic aneurysm and/or aortic dissection. Of these, 20 patients had aortic aneurysm without dissection, 21 aortic aneurysm and dissection, and 26 aortic dissection without aneurysm. 3DTEE diagnosed the type and location of aneurysm correctly in all patients unlike 2DTEE, which missed an aneurysm in one case. There were four cases of aortic aneurysm rupture. Three of them were diagnosed by 3DTEE but only one by 2DTEE, and one missed by both techniques. The mouth of saccular aneurysm, site of aortic aneurysm rupture, and communication sites between perfusing and nonperfusing lumens of aortic dissection could be viewed en face only with 3DTEE, enabling comprehensive measurements of their area and dimensions as well as increasing the confidence level of their diagnosis. In all patients with aortic dissection, 3DTEE enabled a more confident diagnosis of dissection because the dissection flap when viewed en face presented as a sheet of tissue rather than a linear echo seen on 2DTEE which can be confused with an artifact. 2DTEE missed dissection in one patient. In six cases the dissection flap involved the right coronary artery orifice by 3DTEE and surgery. These were missed by 2DTEE. Aortic regurgitation severity was more comprehensively assessed by 3DTEE than 2DTEE. Aneurysm size by 3DTEE correlated well with 2DTEE and surgery/computed tomography scan. In conclusion, 3DTEE provides incremental information over 2DTEE in patients with aortic aneurysm and dissection. 相似文献
58.
Hooman Kamel John P. Betjemann Babak B. Navi Manu Hegde Karl Meisel Vanja C. Douglas S. Andrew Josephson 《Neurocritical care》2013,19(3):336-341
Background
To determine the incidence of electrographic seizures during continuous electroencephalography (cEEG) in the medical and surgical ICU.Methods
We retrospectively reviewed the records of all adults who underwent cEEG in our medical and surgical ICU over a 4.5 year period. Patients with acute brain injury were excluded. Our primary outcome was cEEG documentation of an electrographic seizure, defined as a rhythmic discharge or spike and wave pattern demonstrating definite evolution and lasting at least 10 s. To assess inter-rater variability in cEEG interpretation, two electrophysiologists independently reviewed all available cEEGs of subjects with electrographic seizures documented on their clinical cEEG report and those of an equal number of randomly selected subjects from the remaining cohort.Results
Kappa analysis showed a value of 0.88, indicating excellent inter-rater agreement. Electrographic seizures were identified in 12 of 105 patients (11 %, 95 % CI 5–18 %). This rate did not change after excluding patients with a history of seizure, remote brain injury, or seizure-like events before cEEG. In an ordinal logistic regression model controlling for age, sex, and SOFA score, electrographic seizures were associated with lower odds of good outcomes on the Glasgow Outcome Scale at discharge (OR 0.3, 95 % CI 0.1–0.8).Conclusion
In a tertiary care medical and surgical ICU, electrographic seizures were seen on 11 % of cEEGs ordered for the evaluation of encephalopathy, and were associated with worse functional outcomes at discharge. Our findings confirm the results of a prior study suggesting a substantial burden of electrographic seizures in critically ill encephalopathic patients. 相似文献59.
Kamel Charradi Salem Elkahoui Ferid Limam Ezzedine Aouani 《The journal of physiological sciences : JPS》2013,63(6):445-455
Obesity is a public health problem characterized by increased accumulation of fat into adipose tissues leading to oxidative stress, dyslipidemia, and chronic inflammatory status. We used an experimental model of high-fat diet-induced obesity to analyze the link between dyslipidemia, oxidative stress, and fat accumulation into adipose tissue of rats, as well as the involvement of intracellular mediators such as transition metals on signal transduction. We also looked at the ability of a grape seed and skin extract (GSSE) from a Tunisian cultivar to prevent fat-induced disturbances. Data showed that a high-fat diet (HFD) provoked dyslipidemia into plasma which is linked to an oxidative stress, an accumulation of transition metals such as manganese, copper, and zinc and a depletion of iron. GSSE prevented dyslipidemia by modulating lipase activity, together with increased antioxidant capacity and depletion of transition metals as well as of free radicals such as O2 ? and OH. These data indicated that GSSE has important preventive effects on HFD-induced obesity and oxidative stress whose transduction seems to involve transition metals. GSSE should be used as a safe anti-obesity agent that could find potential applications in metabolic disorders involving transition metals dyshomeostasis. 相似文献
60.