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61.
HIROJI UEMURA MASAFUMI NAKAMURA HISASHI HASUMI SHINPEI SUGIURA KIYOSHI FUJINAMI YASUHIDE MIYOSHI MASAHIRO YAO YOSHINOBU KUBOTA 《International journal of urology》2004,11(7):494-500
BACKGROUND: The aim of this study was to identify predictors that can increase the accuracy of detecting prostate cancer on subsequent biopsies. METHODS: Between 1998 and 2003, a total of 235 men with prostate specific antigen (PSA) levels between 4.0 and 20 ng/mL underwent one or more systematic needle biopsies of the prostate. Of these men, 73 (31.1%) underwent one repeat biopsy and 26 (11.1%) underwent two or more repeat biopsies. We evaluated the results of prostate biopsies in relation to the morbidity of prostate cancer detected on repeat biopsies. RESULTS: Of the 73 men who underwent repeat biopsy, 16 (21.9%) had prostate cancer. Twenty-six men with one negative re-biopsy underwent two or more repeat biopsies, and five of these patients were found to have early stage prostate cancer. On repeat biopsy, there was a significant difference in percent free PSA between the cancer-detected group and the no-cancer-detected group (P < 0.01). A receiver operating characteristics (ROC) curve gave an optimal cut-off value for percent free PSA of 11%, demonstrating a significant difference in the cancer detection rate on repeat biopsy (P = 0.0009). Analysis of the data for re-biopsies showed that cancer-detected cases showed a raised PSA value and a simultaneously reduced percent free PSA (these differences were statistically significant). CONCLUSIONS: A low percent free PSA level increased the probability of a positive result in repeat biopsy. An increase in the accuracy of detecting cancer, especially on repeat biopsy, will promote the detection of more early stage prostate cancer. 相似文献
62.
TOMOHIRO TAKAYA CHIKAKO IKEDA NAOYA IMAGAWA KIYOSHI NIWA KANJI TAKADA 《The Journal of pharmacy and pharmacology》1995,47(6):474-478
A peroral dosage form was examined to deliver recombinant human granulocyte colony-stimulating factor (rhG-CSF) to the colon in beagle dogs. A new gelatin capsule with its inside surface coated with ethylcellulose was prepared for this purpose. RhG-CSF was dissolved with propylene glycol and was filled in the capsule. Several kinds of ethylcellulose-gelatin capsules with an ethylcellulose layer of thickness 46 to 221 mm were used. The capsule was filled with propylene glycol solution containing fluorescein as an absorption marker, castor oil derivative and citric acid. The hardness of the capsule was tested after the gelatin layer was dissolved using a hardness tester and was dependent on the thickness of the ethylcellulose layer of the capsule. The time, Tmax, at which plasma fluorescein level reaches its maximum following oral administration of ethylcellulose capsules was used as a parameter for the in-vivo disintegration time of the ethylcellulose capsule into the colon. Capsules of thickness 84 mm with a Tmax of 4–6 h were filled with rhG-CSF solution containing fluorescein and were administered to dogs. After administration, blood samples were collected for 96 h and the blood total leucocyte (BTL) counts were measured as a pharmacological index of rhG-CSF. The maximum BTL count appeared at 10 h then gradually decreased and returned to its normal level at 48 h. These results suggest the usefulness of ethylcellulose capsules for the delivery of rhG-CSF to the colon and the possibility of a new oral rhG-CSF dosage form has been elucidated. 相似文献
63.
YOSHIHIRO KADONO MD HIROYUKI KANEDA MD KIYOSHI MAEDA MD 《Psychiatry and clinical neurosciences》1995,49(4):231-236
Abstract We found inhibitory effects of antidepressants (clomipramine, maprotyline, mianserin and zimelidine) and 5-hydroxytryptophan (5-HTP) on thyroid stimulating hormone (TSH) release induced by ether stress in freely moving rats. We confirmed that ether stress suppressed the plasma TSH levels after 30 min. We then injected intravenously 250 ng thyrotropin releasing hormone (TRH), 0.1 mg/kg clomipramine, 2.5 mg/kg maprotyline, 2.5 mg/kg mianserin, 0.5 mg/kg zimelidine and 25 mg/kg 5-HTP simultaneously. These materials blocked the influences on plasma TSH levels by the ether stress. Serotonergic antidepressants (clomipramine, zimelidine) and 5-HTP (precursor of serotonin) had a higher potency against the ether stress. These results suggest that antagonizing effects against the ether stress may involve the serotonergic system in the pituitary gland. 相似文献
64.
YOSHINORI ITOH TAKETOSHI SUGIMOTO YOJIRO UKAI AKIRA MORINO KIYOSHI KIMURA 《The Journal of pharmacy and pharmacology》1995,47(10):833-836
The concentration of NS-3 (montirelin hydrate, CG 3703), a thyrotropin-releasing hormone (TRH) analogue, in the cerebral cortex of urethane-anaesthetized rats was measured after its systemic administration (1 mgkg?1, i.v.), using in-vivo microdialysis coupled with a radioimmunoassay. The concentration in microdialysates was highest (24nM) during the first 20 min after injection, and it fell below the detection limit (3.5 nM) 100 min after treatment. The maximal interstitial concentration was estimated to be 0.51 μM. From these results, it is suggested that NS-3 can readily penetrate into the brain. 相似文献
65.
KAZUHIKO SEYA IZUMI MIKI KIYOSHI MURATA HISAE JUNKE SHIGERU MOTOMURA TSUTOMU ARAKI YASUTO ITOYAMA YOSHITERU OSHIMA 《The Journal of pharmacy and pharmacology》1998,50(7):803-807
We have investigated the pharmacological properties of pteleprenine, a quinoline alkaloid, on contractile responses of the guinea-pig ileum and on inotropic responses of the canine left atrium. Although pteleprenine (0·1–1 μM) had no effect on the contraction of the ileum induced by acetylcholine at 10 μM it significantly inhibited acetylcholine-induced contraction of the ileum. Pteleprenine (0·1–10 μM) reduced nicotine induced-contraction of the ileum in a concentration-dependent manner yet had no maximum relaxant effect even at a concentration of 10 μM From Schild analysis the pA2 of pteleprenine on the guinea-pig ileum was found to be 6-6. The contraction of the ileum induced by 10 μM 1,1-dimethyl-4-phenylpiperazinium, a specific agonist of nicotinic acetylcholine. receptors, was concentration-dependently suppressed by 10 nM-10 μM pteleprenine. In contrast, 0.1–10 μM pteleprenine did not antagonize the acetylcholine- and nicotine-induced negative inotropic contractile responses of the canine left atrium. These results show that pteleprenine has inhibitory action against nicotinic acetylcholine receptors in the guinea-pig ileum but not in the canine left atrium. Our findings also suggest that pteleprenine might be a novel lead compound as a nicotinic receptor antagonist. 相似文献
66.
KIMITAKA KOGURE YUKIO NAGAMACHI KIYOSHI SASAMOTO TERUO OGAWA 《Journal of gastroenterology and hepatology》1987,2(4):325-331
A 38 year old man with a huge liver cell adenoma extending to the pelvis was treated by left lateral lobectomy. The tumour, which was well-encapsulated by fibrous membrane, was 18 × 19 × 6 cm in size and weighed 1500g. Histopathologically, this tumour was composed of well-differentiated liver cell trabeculae and a small number of pseudobiliary ducts, but no Glisson sheaths. For the past 4 years 8 months he has remained asymptomatic. Thirty cases of liver cell adenoma found in Japanese literature are reviewed here and possible pathogenic implications are discussed. 相似文献
67.
KAZUTOSHI FUJITA KAZUO NISHIMURA YUTAKA YASUNAGA OSAMU MIYAKE SEIICHI HIROTA AKIHIKO OKUYAMA 《International journal of urology》2003,10(9):492-494
A 36-year-old man presented with macroscopic hematuria associated with right flank pain. Examination of the patient revealed a cystic mass in the right kidney. Because the mass had increased in size, enucleation of the mass was performed. Histopathological findings revealed nephroblastoma, therefore, radical nephrectomy was performed. We believe the pathogenesis of the cystic formation to be a process in which a tumor that had developed in the pericalyceal region spontaneously ruptured, exuding urine into the perinephric space, forming a cystic mass. The patient is alive with no evidence of disease 24 months after the operation. 相似文献
68.
NAMIO HIROSHI; KOYAMA YASUO; KODAMA TETSUO; ITABASHI MASAYUKI; HIROTA TERUYUK 《Japanese journal of clinical oncology》1980,10(2):321-332
A case of multiple carcinomas, three in the stomach, six inthe colon and rectum and one in the nasal vestibule, is reported.The first carcinoma developed in the stomach when the patientwas 36 and was treated by partial distal gastrectomy in a ruralhospital. Subsequently, he received laparotomies six times in28 years, in which six independently developing carcinomas inthe stomach and colorectum were removed. Five adenomas of therectum were removed also by endoscopic polypectomy. A sebaceousgland carcinoma of the nasal vestibule was excised later. Hedied at age 64 of general carcinosis. At autopsy, two more primarycarcinomas were found, one in the stomach remnant and the otherin the descending colon. An adenoma in the right lobe of thethyroid was also found. Metastatic lesions were disseminatedto the lung, liver, lymph nodes, bone and several other organs. 相似文献
69.
OZAKI HIDEO; ITO ICHIJI; SANO RYOZO; HIROTA TERUYUKI; SHIMOSATO YUKIO 《Japanese journal of clinical oncology》1971,1(1):83-94
A case of primary choriocarcinoma of the stomach in an adultmale has been reported. The diagnosis was authenticated by morphological,biological and immunological examinations. In spite of the radicaloperation for the primary gastric lesion and anti-cancer chemotherapyusing Mitomycin-C and Endoxan, early death resulted from bleedingfrom a metastatic focus in the liver. Histologically, the choriocarcinomawas associated with adenocarcinoma in this case, similar tocases reported in the literature. Metastatic foci in the liver,lungs and lymph node possessed features of choriocarcinoma.At autopsy meticulous search failed to reveal any other possibleprimary foci than the stomach. Five cases of primary gastric choriocarcinoma verified histologicallyand biologically have been found in English and German literatures,which were reviewed, and histogenesis of gastric choriocarcinomawas discussed.
*The case was presented at the 25th Annual Meeting of the JapaneseCancer Association (1966). 相似文献
70.
Basilua Andre MUZEMBO Masamitsu EITOKU Yuta INAOKA Makiko OOGIKU Mitomo KAWAKUBO Ryuta TAI Momoko TAKECHI Ken-ichi HIRABAYASHI Naofumi YOSHIDA Nlandu Roger NGATU Ryoji HIROTA Bernardus SANDJAYA Narufumi SUGANUMA 《Industrial health》2014,52(3):256-261
Allergy to laboratory animals is a well known occupational hazard and remains a health
concern for individuals in contact with lab animals. This study evaluates the prevalence
of allergy symptoms among medical researchers exposed to laboratory animals. We analyzed
data from a cross-sectional survey, involving subjects (n=169, 21–59 yr), working in Kochi
Medical School, Japan. They were asked to fill out a questionnaire to evaluate symptoms
related to contact with laboratory animals. The overall response rate was 86.2%. The
prevalence of laboratory animal allergy was 17.6%. The symptoms most reported were
allergic rhino-conjunctivitis and asthma. A small number of the subjects received
education on the allergy issue and 62.5% of subjects with an allergy to laboratory animals
claimed to have atopy. Protection from animal allergens should be a high priority for
institutions using lab animals; providing continuous education to animal handlers would be
meaningful to reduce and control exposure. 相似文献