Inhaled natural human interferon alpha induces bronchospastic reactions in asthmatics.

There is a relationship between viral infection and aggravation of bronchial asthma symptoms. Viruses belong to the strongest and fast acting inducers of interferon (IFN), which, in turn, may enhance histamine release from effector cells. We have administered IFN intrabronchially to 49 patients suffering from bronchial asthma. The impairment of lung ventilation with significant decrease of forced expiratory volume in one second (FEV1) have been observed in majority of the patients who inhaled crude or purified IFN preparations.     

战士体内VitB_1、VitB_2储备水平检测

选择南方热区某特种部队战士５２人，分两组分别口服５ｍｇＶｉｔＢ１和ＶｉｔＢ２，收集４ｈ尿液，用荧光法进行负荷试验。结果：ＶｉｔＢ１组，所测２９人中，１５人缺乏，９人不足，２人正常，３人充裕；ＶｉｔＢ２组，所测２３人中，１１人缺乏，１２人不足，反映该部队全年约５％的发病是由于ＶｉｔＢ１、ＶｉｔＢ２缺乏不足所致。其原因为膳食摄入不够     

微粒皮肤移植治疗特大面积烧伤：附7例报告

报告应用微粒皮肤移植技术抢救成功７例特大面积烧伤病人。文中介绍了手术方法、注意事项，指出了本术式的优缺点，并对该领域国内外的发展状况，作了简单叙述。     

Activated neutrophils aggravate endothelial dysfunction after reperfusion of the ischemic feline myocardium.

Endothelial dysfunction, as evidenced by decreased stimulated release of endothelium-derived relaxing factor (EDRF), occurs after reperfusion of the ischemic myocardium. To better understand this endothelial dysfunction, isolated cat hearts were perfused under constant flow by the Langendorff procedure with Krebs-Henseleit solution devoid of blood cells. Following global ischemia (90 minutes) and reperfusion (20 minutes), coronary vasorelaxation to the endothelium-dependent vasodilator acetylcholine (ACh) was 70 +/- 3% of initial values (p less than 0.01) compared with 90 +/- 4% in nonischemic control perfused hearts. No decrement occurred in response to the endothelium-independent vasodilator nitroglycerin (NTG). Coronary artery rings isolated from the ischemic left circumflex coronary artery showed a similar degree of endothelial dysfunction to ACh, with normal relaxation in response to NaNO2. Autologous cat neutrophils (100 million cells), activated with 100 nmol/L f-met-leu-phe infused into the heart directly before and throughout reperfusion, resulted in a further decrement in ACh-induced vasodilation, to 55 +/- 5% of initial response, with no effect on NTG-induced vasodilation. Similar results were obtained with coronary artery rings isolated from perfused cat hearts and exposed to neutrophils. This neutrophil-enhanced endothelial dysfunction was inhibited by human superoxide dismutase as well as by an antibody to the adherence glycoprotein complex CD-18 (i.e., MAbR 15.7). Therefore endothelial dysfunction occurs initially upon reperfusion of the previously ischemic heart and is aggravated by superoxide radicals produced by activated neutrophils.     

头皮缺损颅骨外露的修复

我科1980～1991年收治外伤性或颅面部肿瘤切除后头皮缺损颅骨外露9例,分别应用吻合血管的游离大网膜结合中厚皮片移植、游离皮瓣或轴型皮瓣转位结合皮片移植修复。讨论了修复时机、修复方法以及手术注意事项。认为双侧股前外侧游离皮瓣是修复全头皮缺损颅骨外露的可取方法,而吻合血管的游离大网膜移植修复颅骨外露的方法应尽量避免。     

小剂量γ线照射及合并噪声暴露对豚鼠外周血NK细胞活性的影响

实验研究了小剂量γ线照射及合并噪声暴露对脉鼠外周血ＮＫ细胞活性的影响。结果表明，单纯γ线照射和单纯噪声暴露组动物外周血ＮＫ细胞活性较对照组部有一定程度的增高，其中尤以后者为明显。但噪声暴露对γ线照射引起的ＮＫ细胞活性无明显影响；而γ线照射对噪声暴露引起的ＮＫ细胞活性却表现有一定的拮抗作用，其机理有待探讨。     

Correlation between Cyclin A Gene Expression in Adult Patients with Acute Leukemia and Drug Resistance

Adultacuteleukemia (AL)isoneofthemostcommonmalignanttumorsofhematology .Withtherecentprogressinchemotherapyandsupportivether apy ,theremissionandsurvivalrateinALhavebeenmarkedlyimproved .However ,drugresistanceandrelapsearestillimportantfactorsaffectinglongsur vivalofthese patients .Theabnormalregulationofcellcycleisanotherfactorthatcannotbeignoredex ceptformultipledrugresistance (MDR) .WedetectcyclinA ,multidrugresistantgene (mdrl) ,topoiso meraseⅡα(TopⅡα)andbcl 2inadultpatientswithA…     

从早产儿脐带血中分离出流行性出血热病毒的探讨

１９９２年１２月作者从一位ＥＨＦ患者的早产儿脐带血中分离出ＥＨＦＶ，证实ＥＨＦＶ沿母、婴垂直途径传播的可能性。     

辽宁产东亚钳蝎毒镇痛作用与脑内中枢关系的研究

应用立体定位、核团内注射与电解损毁核团技术及微电极细胞外记录方法，以猫丘脑后核内脏大神经诱发单位放电为内脏痛指标，观察向尾状核、中脑导水管周围灰质及杏仁内侧核内注入东亚钳蝎毒及在电解损毁３个核团前后ＰＯ内脏大神经诱发单位放电的变化。在损毁诸核之前刺激内脏大神经引起单位诱发放电，损毁诸核之后诱发放电减弱或消失，这与辽宁产东亚钳蝎毒注入诸核团中的作用相一致。表明蝎毒的作用部位与上述核团有关，更进一步证明蝎毒作用部位     

广东汉族人群HLA-Cw多态性及单体型分析

目的检测广东汉族人群HLA．Cw及HLA-A、B、DRB1基因频率，分析该人群HLA-Cw等位基因多态性及其单体型特点。方法骨髓移植供者185例，抗凝血提取DNA，半量全自动PCR-RSSO分型检测HLA-A、B、Cw、DRB1基因型。结果在分辨水平检出Cw等位基因11个，其中分布频率较高的依次为：Cw*03(0．2580)、Cw*07(0．1887)、Cw*01(0．1732)、Cw*08(0．1070)。统计分析呈现显著连锁不平衡的HLA-Cw．A单体型7个，HLA-Cw-B单体型20个，HLA—Cw．DRB1单体型10个。结论广东汉族群体HLA-Cw基因具有较为丰富的多态性，其与HLA-A、B、DRB1间连锁不平衡单体型具有地区性遗传特征。