全文获取类型
收费全文 | 5921篇 |
免费 | 434篇 |
国内免费 | 43篇 |
专业分类
耳鼻咽喉 | 56篇 |
儿科学 | 149篇 |
妇产科学 | 65篇 |
基础医学 | 1050篇 |
口腔科学 | 108篇 |
临床医学 | 452篇 |
内科学 | 1428篇 |
皮肤病学 | 198篇 |
神经病学 | 467篇 |
特种医学 | 130篇 |
外科学 | 679篇 |
综合类 | 18篇 |
预防医学 | 236篇 |
眼科学 | 104篇 |
药学 | 552篇 |
中国医学 | 14篇 |
肿瘤学 | 692篇 |
出版年
2023年 | 42篇 |
2022年 | 60篇 |
2021年 | 149篇 |
2020年 | 80篇 |
2019年 | 108篇 |
2018年 | 127篇 |
2017年 | 112篇 |
2016年 | 144篇 |
2015年 | 147篇 |
2014年 | 179篇 |
2013年 | 219篇 |
2012年 | 333篇 |
2011年 | 388篇 |
2010年 | 193篇 |
2009年 | 188篇 |
2008年 | 345篇 |
2007年 | 354篇 |
2006年 | 348篇 |
2005年 | 338篇 |
2004年 | 367篇 |
2003年 | 358篇 |
2002年 | 327篇 |
2001年 | 118篇 |
2000年 | 88篇 |
1999年 | 92篇 |
1998年 | 64篇 |
1997年 | 66篇 |
1996年 | 45篇 |
1995年 | 44篇 |
1994年 | 46篇 |
1993年 | 38篇 |
1992年 | 74篇 |
1991年 | 78篇 |
1990年 | 81篇 |
1989年 | 70篇 |
1988年 | 76篇 |
1987年 | 77篇 |
1986年 | 76篇 |
1985年 | 57篇 |
1984年 | 47篇 |
1983年 | 48篇 |
1982年 | 28篇 |
1981年 | 20篇 |
1980年 | 16篇 |
1979年 | 33篇 |
1978年 | 10篇 |
1977年 | 18篇 |
1969年 | 11篇 |
1967年 | 7篇 |
1966年 | 8篇 |
排序方式: 共有6398条查询结果,搜索用时 15 毫秒
41.
42.
Kuniaki Tanaka Yoshifumi Tomita Mari Tsuruta Fumiko Konishi Masao Okuda Kunisuke Himeno Kikuo Nomoto 《Immunopharmacology and immunotoxicology》1990,12(2):277-291
Chlorella vulgaris, an unicellular green algae, or its acetone-extract (Ac-Ex) were administered orally to Meth A tumor bearing BALB/c or (BALB/c DBA/2)F1 (CDF1) mice. When CDF1 mice were fed daily with 10% dried powder of Chlorella vulgaris (CVP) containing diet before and after Meth A tumor inoculation, the growth of rechallenged Meth A tumor was significantly suppressed in an antigen-specific manner. Augmentation of antitumor resistance was exhibited also by Winn assay using lymph node cells of tumor-bearing mice orally administered with CVP or Ac-Ex. Antigen-specific concomitant immunity in these mice were mediated by cytostatic T cells but not by cytotoxic T cells. Natural killer cells seemed not to contribute in antitumor resistance in this system. 相似文献
43.
A study on the immunopathological similarities between IgA nephropathy and Henoch-Schoenlein purpura (HSP) nephritis is described. Various examinations were performed as follows. (1) Pathological studies: light microscopic findings and immunofluorescent staining; (2) Measurement of the levels of IgA in pharyngeal washings and sera, and those of IgA quantitated by radial immunodiffusion; (3) Elution studies: renal biopsy specimens obtained from patients with IgA nephropathy and HSP nephritis were treated with citrate buffer (pH 3.2) and the "eluate" was neutralized by sodium hydroxide. The "eluate" was then applied to the acid-treated sections obtained from the same and other patients with IgA nephropathy as well as sections from patients with HSP nephritis and other glomerular diseases. The sections were stained with FITC-conjugated heavy chain specific antihuman IgA antisera and then examined with a fluorescent microscope. There were no differences in pathological findings of IgA nephropathy and HSP nephritis in the light microscopic and immunofluorescent examinations. The levels of IgA in pharyngeal washings and sera were significantly increased in patients with both diseases. IgA antibodies deposited in kidneys from patients with HSP nephritis crossreacted with kidneys from some patients with IgA nephropathy, and vice versa. However, antibodies from patients with IgA nephropathy and HSP nephritis did not react with normal glomeruli or other nephritic glomeruli. It is concluded that there are some immunopathological similarities between IgA nephropathy and HSP nephritis. 相似文献
44.
45.
46.
47.
48.
Kiyoshi Imaizumi Junko Kimura Mari Matsuo Kenji Kurosawa Mitsuo Masuno Norio Niikawa Yoshikazu Kuroki 《American journal of medical genetics》2002,107(1):58-60
We describe a de novo balanced reciprocal translocation between the long arms of chromosomes 5 and 8 [46,XX,t(5;8)(q35;q24.1)] in a 15-month-old girl with a typical Sotos syndrome phenotype. Involvement of the 5q35 region was previously reported (Maroun et al. [1994: Am J Med Genet 50:291-293]) as one of translocation breakpoints in the present patient. We suggest that the gene responsible for Sotos syndrome is located to a distal long-arm region of chromosome 5. 相似文献
49.
Shimada M Hino F Yamamoto J Mukai H Hosobe T Onodera S Hoshina S Machida K 《Rinsho byori. The Japanese journal of clinical pathology》2003,51(11):1061-1067
The isothermal and chimeric primer-initiated amplification of nucleic acids (ICAN) is a new isothermal DNA amplification method composed of exo Bca DNA polymerase, RNaseH and DNA-RNA chimeric primers. We developed the simultaneous detection system for Chlamydia trachomatis/Neisseria gonorrhoeae DNA, combined with luminescence detection by a probe hybridization. In the performance tests, this system was able to detect 10 to 100 copies of C. trachomatis/N. gonorrhoeae DNA for only 3.5 hours, and was highly specific to C. trachomatis/N. gonorrhoeae without any cross-reaction to C. pneumoniae, N. lactamica, N. sicca or N. meningitidis. When we tested 60 clinical samples of urine and cervical swabs, the interpretive results were completely consistent with those obtained by Roche PCR system. Of 13 positive samples by the ICAN and PCR systems for C. trachomatis, four were negative by EIA method(IDEIA Chlamydia). These results indicate that the ICAN system is an efficient and sensitive system to simultaneously detect C. trachomatis/N. gonorrhoeae DNA. 相似文献
50.
Patients with IgA nephropathy show an emergence of IgA dominant circulating immune complexes (CIC) as well as increased levels of serum IgA and/or IgA bearing peripheral blood lymphocytes. In order to elucidate immunological aberrations responsible for the increased IgA synthesis in such patients, quantitative and qualitative analysis was performed on T alpha cells which have been recently identified as possessing IgA specific helper activity on human B cells. Three different methods were employed to quantitate T alpha cells. These methods included a rosette formation of T cells with either bovine red cells coated with the IgA fraction of anti-bovine red cell antiserum or those coated with TNP and anti-TNP IgA antibody, and an analysis of T cells combined with fluorescein conjugated human IgA myeloma protein. T alpha cells were sorted by a fluorescence activated cell sorter and co-cultured with a B cell rich fraction to evaluate whether there is a qualitative difference in IgA specific helper activity between patients and healthy adults. T alpha cells were significantly increased in patients with IgA nephropathy while there were no significant changes in patients with chronic proliferative glomerulonephritis without mesangial deposition of IgA. There was no qualitative difference in IgA specific helper activity of T alpha cells between patients and healthy adults. It is suggested that increased levels of T alpha cells in patients with IgA nephropathy may be responsible for increased synthesis of IgA in such patients. 相似文献