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991.
Marugami N Hirohashi S Kitano S Takahama J Ito T Torimoto K Hirao Y Kichikawa K 《Radiation Medicine》2008,26(1):42-45
We present a case of polypoid endometriosis of the ureter that showed bilateral polypoid intraluminal masses in the lower
part of the ureter mimicking ureteral fibroepithelial polyps, arising with a background of pelvic endometriosis and a history
of gonadotropin releasing hormone (GnRH) therapy. Magnetic resonance imaging revealed the masses to have high signal intensity
on T2-weighted imaging. The location and bilaterality of the polypoid intraluminal masses are considered useful points in
the differential diagnosis of fibroepithelial polyps. 相似文献
992.
Fujii S Matsusue E Kigawa J Sato S Kanasaki Y Nakanishi J Sugihara S Kaminou T Terakawa N Ogawa T 《European radiology》2008,18(2):384-389
Our purpose is to evaluate the diagnostic accuracy of apparent diffusion coefficient (ADC) measurement in differentiating
malignant from benign uterine endometrial cavity lesions. We retrospectively evaluated 25 uterine endometrial cavity lesions
in 25 female patients: endometrial carcinoma (n = 11), carcinosarcoma (n = 2), submucosal leiomyoma (n = 8), and endometrial
polyp (n = 4). Diffusion-weighted images were performed at 1.5 T with b factors of 0–1,000/mm2. The region of interest was defined within the tumor on T2-weighted EPI image and then manually copied to an ADC map. Thereby,
the ADC value was obtained. We compared ADC values between malignant and benign lesions using Student’s t-test. The mean and
standard deviation of ADC values (×10−3 mm2/s) were as follows: endometrial carcinoma, 0.98±0.21; carcinosarcoma, 0.97±0.02; submucosal leiomyoma, 1.37±0.28; and endometrial
polyp, 1.58±0.45. The ADC values differed significantly between malignant (0.98±0.19) and benign lesions (1.44±0.34) (P < 0.01).
We defined malignant tumors as cases with an ADC value less than 1.15 × 10−3 mm2/s for obtaining the highest accuracy. Sensitivity, specificity, and accuracy were 84.6%, 100%, and 92%, respectively. ADC
measurement can provide useful information in differentiating malignant from benign uterine endometrial cavity lesions. 相似文献
993.
Hata T Tanaka H Noguchi J Inubashiri E Yanagihara T Kondoh S 《Ultrasound in medicine & biology》2010,36(11):1808-1812
The objective of this study was to measure the fetal gastric volume using three-dimensional (3-D) ultrasound during pregnancy. Three-dimensional sonographic examinations were performed involving 35 pregnant women from 12 to 38 weeks of gestation. The fetal gastric volume was monitored every 5 min for a minimum of 40 min (40-60 min) in each woman. The rotational technique with Virtual Organ Computer-aided AnaLysis (VOCAL) was used to calculate the fetal gastric volume. Maximum and minimum gastric volumes were curvilinearly associated with the gestational age, respectively (R(2) = 0.611, p < 0.0001, and R(2) = 0.407, p < 0.0001, respectively). A curvilinear relationship was noted between the functional capacity (maximum volume - minimum volume) of the fetal stomach and gestational age (R(2) = 0.531, p < 0.0001). The maximum volume change [(maximum volume - minimum volume/maximum volume) × 100] did not change during pregnancy (mean and standard deviation, 64.1% ± 16.1%). However, gastric emptying cycles could not be determined in this study because of the short observation period and small number of subjects. Our findings suggest that the fetal gastric volume calculated by conventional two-dimensional ultrasound in previous investigations is approximately one-third of the maximum volume using 3-D ultrasound in the present study and that 3-D ultrasound is a superior means of evaluating the fetal gastric volume in utero. However, the data and their interpretation in the present study should be viewed with some degree of caution because of the small number of subjects. Further studies involving a larger sample size are needed to confirm these findings. 相似文献
994.
Naoto Furukawa Munetaka Takekuma Nobutaka Takahashi Yasuyuki Hirashima 《Archives of gynecology and obstetrics》2010,281(5):913-917
Purpose
We have conducted a retrospective, comparative analysis of the accuracy of preoperative diagnosis and frozen section diagnosis relative to postoperative diagnosis. 相似文献995.
Kozue Kishii Naoko Chiba Miyuki Morozumi Keiko Hamano-Hasegawa Iku Kurokawa Junko Masaki Kimiko Ubukata 《Journal of infection and chemotherapy》2010,16(2):87-93
To clarify molecular changes in β-lactamase-nonproducing, ampicillin-resistant (BLNAR) Haemophilus influenzae, which is increasing in pediatric patients with acute otitis media (AOM) in Japan, we identified amino acid (aa) substitutions
in penicillin-binding protein 3 for the BLNAR strains. Of 191 H. influenzae strains isolated from middle ear fluid of pediatric AOM patients between October 2005 and March 2008, BLNAR strains determined
by PCR accounted for 49.2%. Of the BLNAR strains, 91.5% possessed 4 aa substitutions: Met377Ile, Ser385Thr, Leu389Phe, and
either Asn526Lys or Arg517His. Additionally, the emergence of BLNAR strains possessing a new aa substitution of Val329Ala
in the conserved aa motif of Ser327-Thr-Val-Lys, or Val511Ala adjacent to the conserved aa motif of Lys512-Thr-Gly, was noted.
Transformation of the ftsI gene into the Rd reference strain (ATCC 51907) demonstrated that these two aa substitutions reduced susceptibility to amoxicillin
more than to cephalosporins. Pulsed-field gel electrophoretic profiles of BLNAR strains were highly diverse. These results
suggested that inadequate antibiotic use may increase BLNAR strains by selecting mutations in the ftsI gene and that such use may have favored the new aa substitutions. 相似文献
996.
997.
Shinichi Hamada Seishi Nakamura Tetsuro Sugiura Takashi Nishiue Junko Watanabe Kengo Hatada Hironori Miyoshi Masato Baden Toshiji Iwasaka 《European journal of nuclear medicine and molecular imaging》2001,28(3):327-333
To avoid the haemorrhagic risk of unnecessary thrombolysis in acute myocardial infarction (MI), early and precise diagnosis of spontaneous recanalization (SR) of the infarct-related artery is required. To clarify the accuracy of technetium-99m tetrofosmin myocardial single-photon emission tomography (SPET) in the detection of SR in patients with acute anterior MI, electrocardiography (ECG), echocardiography and 99mTc-tetrofosmin SPET imaging were performed in 49 patients with acute anterior MI before emergency coronary angiography. Defect score was calculated as the sum of the perfusion defects of each segment: from 3 (complete defect) to 0 (normal perfusion). Echocardiographic asynergic score (the sum of asynergic grades) and the greatest ST elevation of the 12-lead ECG on admission were also measured. SR was defined as Thrombolysis in Myocardial Infarction (TIMI) grade 3 flow on emergency coronary angiography. Defect score in 11 patients with SR (9.2Dž.7) was significantly lower than that in 38 patients without SR (18.5LJ.0) (P<0.001), whereas there were no significant differences in asynergic score and ST elevation between the two groups. From the receiver operating characteristic curves, the optimal cut-off points of defect score, asynergic score and ST elevation for the detection of SR were calculated to be 12, 13 and 3.5, respectively. The sensitivity and specificity of the scintigraphic defect score (91% and 89%) were significantly higher than those of the asynergic score (64% and 68%) and ST elevation (73% and 71%). Thus, 99mTc-tetrofosmin SPET imaging on admission is a very accurate method for the detection of SR in patients with acute anterior MI. 相似文献
998.
Amplification of the c-er bB-2 gene (located on 17q11.2--12) is accompanied by overexpression of its cell surface receptor product, p185(ERBB2). In pulmonary carcinomas, however, there has been disagreement between the reported frequencies of gene amplification and overexpression. To clarify their relationship, the correlation between the cellular expression of p185(ERBB2) and the level of c-erb B-2 gene amplification was studied. A total of 195 pulmonary carcinomas (182 primary and 13 metastatic) were examined immunohistochemically using a polyclonal antibody, which recognizes the internal domain of the human c-erb B-2 protein, and positive tumors were further examined for the gene amplification by dual-color fluorescence in situ hybridization using probes for centromere 17 and 17q11.2--12. By immunohistochemistry, distinct membrane staining was found in an adenocarcinoma, a large cell carcinoma and a metastatic carcinoma from the breast, and cytoplasmic and/or faint membranous staining was observed in 23 non-small cell lung carcinomas. It was in the two primaries and the metastatic carcinoma that more than 8-fold amplification of c-erb B-2 was found by fluorescence in situ hybridization. Especially, in the two primary carcinomas, tumor cells had amplified genes with the signals forming one or two clusters, indicating that the amplified gene was present in homogeneously staining regions. Among the 23 tumors, three tumors showed low-level amplification (less than 3-fold), which was differentiated from polysomy 17 found in the other two. In the 30 non-small cell lung carcinomas selected at random from 151 with negative immunostaining, there were five trisomy 17, but no tumors with the gene amplification. This suggests that although c-erb B-2 amplification in pulmonary carcinoma is rare, it occurs in the form of a homogeneously staining region and is thought to control the overexpression of the protein in the cell membrane. New adjuvant therapy using a humanized antibody to the oncoprotein may be beneficial to patients with these tumors. 相似文献
999.
Junichi Honda Takehide Fumimori Nobukuni Yosida Junko Yonemitsu Hiromoto Kitajima Kotaro Oizumi 《Food and Agricultural Immunology》2001,13(4):265-273
We investigated the influence of extracts from the mackerel (BM-1) on the production of IL-2 and IFNγ from lymphocytes. Intracellular IL-2 or IFNγ of lymphocytes activated with anti-CD3 monoclonal antibody (MAb) and PMA, or anti-CD3 MAb and PHA were analyzed by a flow-cytometer. The number of IL-2 or IFNγ positive-lymphocytes (CD4 positive or CD8 positive) was significantly decreased when the lymphocytes were treated with BM-1. Moreover, the production of IL-2 or IFNγ from lymphocytes were determined by ELISA systems. BM-1 inhibited the production of IL-2 and IFN γ from lymphocytes in a dose-dependent manner. Furthermore, we observed the effects of BM-1 on the calcium mobilization of lymphocytes activated with anti-CD3 MAb. BM-1 did not effect the initial, rapid phase (EGTA-insensitive component) of the TCR-stimulated increase in [Ca2+]i. BM-1 inhibited the influx of extracellular Ca2+. These results suggest that BM-1 inhibits the production of IL-2 and IFNγ from lymphocytes via the suppression of calcium influx through plasma membrane channels. 相似文献
1000.
Recent Advances In the Pathology of Alcoholic Myopathy 总被引:5,自引:0,他引:5
Victor R. Preedy Junko Adachi Timothy J. Peters Simon Worrall Seppo Parkkila Onni Niemela Migiwa Asamo Yasuhino Ueno Kunihiko Takeda Masayoshi Yamauchi Kazuhiko Sakamoto Masaru Takagi Hisato Nakajima Gotaro Toda 《Alcoholism, clinical and experimental research》2001,25(S1):54S-59S
This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were Victor R. Preedy and Junko Adachi. The presentations were (1) Alcoholic myopathy: Past, present and future, by Timothy J. Peters and Victor R. Preedy; (2) Protein adducts in the type I and II fiber-predominant muscles of the ethanol-fed rat, by Simon Worrall, Seppo Parkkila, and Onni Niemela; (3) Hydroperoxides and changes in alcoholic myopathy, by Junko Adachi, Migiwa Asamo, and Yasuhino Ueno; and (4) A close association between testicular atrophy, muscle atrophy, and the increase in protein catabolism after chronic ethanol administration, by Kunihiko Takeda, Masayoshi Yamauchi, Kazuhiko Sakamoto, Masaru Takagi, Hisato Nakajima, and Gotaro Toda. 相似文献