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91.
Changes in energy during treatment of depression: an analysis of fluoxetine in double-blind, placebo-controlled trials 总被引:8,自引:0,他引:8
Judge R Plewes JM Kumar V Koke SC Kopp JB 《Journal of clinical psychopharmacology》2000,20(6):666-672
More than two thirds of patients with depression present with symptoms of fatigue, low energy, and listlessness. Because daytime sedation may be a concern in such patients, a "nonsedating" antidepressant should be considered. The authors examined the effects of fluoxetine on depression-related disturbances in energy. Data from seven double-blind, placebo-controlled clinical trials in 2,075 patients with major depression were retrospectively analyzed. The Hamilton Rating Scale for Depression (HAM-D) Retardation factor score (total of items 1, 7, 8, and 14) was used as the primary measure of energy improvement, whereas the HAM-D-17 total score was used to assess changes in overall depression. Elderly patients (aged 60 years and older) were included in the overall group and were also analyzed separately. In addition, a subgroup analysis was performed using the HAM-D Retardation factor score to categorize patients as having low (score < 8) or high (score > or = 8) levels of retardation at baseline. Beginning at week 3, fluoxetine-treated patients experienced statistically significant reductions in their HAM-D Retardation factor score compared with placebo-treated patients. The reductions for the elderly subgroup were less than those for the overall population, but they were still statistically significant beginning at week 4. Patients in both the low and high baseline retardation groups improved significantly. HAM-D-17 total scores for fluoxetine-treated patients in all groups (total, elderly, high retardation, and low retardation) improved significantly compared with placebo-treated patients. These findings demonstrate that fluoxetine-treated patients experience an improvement in energy symptoms as their overall depression improves. 相似文献
92.
Aldosterone, a new appreciation of its role in heart failure 总被引:1,自引:0,他引:1
Understanding of the role, triggers, and impact of the renin-angiotensin-aldosterone system in cardiovascular disease has significantly broadened. In recent years substantial discoveries have been made regarding the pathophysiology of heart failure, particularly in the area of neurohormonal activation. New interest in therapy with aldosterone antagonists was stimulated by results of a 2-year study of 1663 patients with heart failure that showed a 30% relative risk reduction of death among patients given a subhemodynamic dosage of spironolactone, a nonselective aldosterone antagonist, compared with placebo, in addition to standard therapy of diuretics, angiotensin-converting enzyme inhibitors, beta-blockers, and digitalis. 相似文献
93.
HPLC测定益肤霜中红霉素和地塞米松的含量 总被引:5,自引:0,他引:5
采用HPLC测定益肤霜中红霉素和地塞米松的含量,控制制剂的质量。色谱条件:固定相为Kromasil C18柱;流动相为乙腈-0.2mol/L醋酸铵-水,流速0.8ml/min;检测波长215nm。以c对峰面积A作直线回归,红霉素在1.5-24g/L地塞米松在20-300mg/L的范围内,其浓度与峰面积呈直线关系。红霉素回收率为99.69%;地塞米松的回收率为100.28%。本法操作简便,结果准确, 相似文献
94.
95.
Intakes of calcium, iron, potassium, and magnesium are reported for 77 men and 187 women aged 65 and over and living at home in N. Glasgow. Calcium intakes were below the national average. The importance of milk as a source of calcium and the relevance of calcium intake to bone disease in old age are discussed. Iron intakes were probably adequate, but those of potassium and magnesium may well be below optimum levels. 相似文献
96.
97.
Bram?Fioole Marike?Kokke Richard?van Hillegersberg Inne?HM?Borel RinkesEmail author 《BMC surgery》2005,5(1):7
Background
The purpose of this study was to evaluate the long-term results of partial liver resection for benign liver lesions. 相似文献98.
A patent is a legal device that grants an inventor market exclusivity over a new invention or medication. Market exclusivity
can mean tremendous economic rewards for the patent holder because it provides the inventor with a monopoly over the invention
for the 20-year patent term. Obtaining a patent and retaining market exclusivity can be a treacherous process, especially
in the arena of biotechnology patents. Scientific, legal, and practical considerations must be carefully weighed to best protect
an inventor’s rights. This article explores some common patenting pitfalls as well as emerging issues that are specific to
the area of biotechnology patenting. 相似文献
99.
Marfan's syndrome is a systemic disorder of connective tissue caused by mutations in the extracellular matrix protein fibrillin 1. Cardinal manifestations include proximal aortic aneurysm, dislocation of the ocular lens, and long-bone overgrowth. Important advances have been made in the diagnosis and medical and surgical care of affected individuals, yet substantial morbidity and premature mortality remain associated with this disorder. Progress has been made with genetically defined mouse models to elucidate the pathogenetic sequence that is initiated by fibrillin-1 deficiency. The new understanding is that many aspects of the disease are caused by altered regulation of transforming growth factor beta (TGFbeta), a family of cytokines that affect cellular performance, highlighting the potential therapeutic application of TGFbeta antagonists. Insights derived from studying this mendelian disorder are anticipated to have relevance for more common and non-syndromic presentations of selected aspects of the Marfan phenotype. 相似文献
100.
Background The National Health Strategy envisages a health system incorporating patient views; and providing accessible, consultant-led
dialysis services with patient choice of dialysis modality, in all regions.
Aims To describe patients’ experiences of renal services against National Health Strategy objectives.
Methods Telephone interviews with 192 dialysis patients from three hospitals in the Eastern region.
Results One-quarter of participants (16% of haemodialysis [HD] and 46% of peritoneal dialysis patients) lived outside the Eastern
region, and travelled there because dialysis was not available locally. Two-thirds (65%) had a choice of dialysis modality.
High satisfaction with interpersonal care was observed (83–98% satisfaction). Dissatisfaction with physical environment included
parking (39–56%), waiting areas (62–69%), HD unit space (74%). Regarding support services, dietary services were satisfactory
(92–95%), with lower satisfaction ratings for social and financial support services (62%).
Conclusions Structural and management issues must be addressed to advance a quality agenda for renal care in Ireland. 相似文献