全文获取类型
收费全文 | 106327篇 |
免费 | 476篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 810篇 |
儿科学 | 3596篇 |
妇产科学 | 1585篇 |
基础医学 | 13171篇 |
口腔科学 | 586篇 |
临床医学 | 6477篇 |
内科学 | 21425篇 |
皮肤病学 | 487篇 |
神经病学 | 10547篇 |
特种医学 | 4771篇 |
外科学 | 18447篇 |
综合类 | 938篇 |
预防医学 | 9573篇 |
眼科学 | 1037篇 |
药学 | 5690篇 |
中国医学 | 5篇 |
肿瘤学 | 7661篇 |
出版年
2018年 | 12182篇 |
2017年 | 9977篇 |
2016年 | 11879篇 |
2015年 | 425篇 |
2014年 | 318篇 |
2013年 | 291篇 |
2012年 | 3286篇 |
2011年 | 10786篇 |
2010年 | 8516篇 |
2009年 | 6404篇 |
2008年 | 11372篇 |
2007年 | 14146篇 |
2006年 | 250篇 |
2005年 | 2281篇 |
2004年 | 2821篇 |
2003年 | 4245篇 |
2002年 | 2864篇 |
2001年 | 348篇 |
2000年 | 592篇 |
1999年 | 230篇 |
1998年 | 214篇 |
1997年 | 281篇 |
1996年 | 180篇 |
1995年 | 175篇 |
1994年 | 198篇 |
1993年 | 160篇 |
1992年 | 153篇 |
1991年 | 161篇 |
1990年 | 151篇 |
1989年 | 134篇 |
1988年 | 120篇 |
1987年 | 146篇 |
1986年 | 126篇 |
1985年 | 123篇 |
1984年 | 89篇 |
1983年 | 84篇 |
1982年 | 102篇 |
1980年 | 127篇 |
1979年 | 118篇 |
1978年 | 77篇 |
1977年 | 28篇 |
1976年 | 77篇 |
1974年 | 39篇 |
1970年 | 30篇 |
1969年 | 39篇 |
1938年 | 71篇 |
1937年 | 33篇 |
1934年 | 41篇 |
1932年 | 56篇 |
1930年 | 52篇 |
排序方式: 共有10000条查询结果,搜索用时 203 毫秒
991.
Eelco F. M. Wijdicks 《Neurocritical care》2018,29(3):385-387
Metabolic encephalopathy may be the most common diagnosis in consultative acute neurology. The origin of this term is not generally known but can be traced back. The term replaced more commonly used designations such as organic or functional. The term metabolic encephalopathy was originally linked to organ dysfunction but subsequently became more imprecise. When it expanded to include a large number of diseases, it evolved to “metabolic neuronal dysfunction” and soon could not be distinguished from “quiet delirium” and other designations. This vignette summarizes why the terminology has confused more than clarified but also why it will likely stay in the neurologist’s vernacular. 相似文献
992.
We present the case of a 38-year-old right-hand-dominant female with a longstanding extensive high flow arteriovenous malformation (AVM) affecting the left hand and forearm. The patient’s main complaints were altered sensation in the left hand and difficulty with co-ordination. Clinical examination revealed reduced global sensibility in the hand and evidence of a vascular steal phenomenon resulting in a cold thumb and small finger without trophic changes. Subsequent nerve conduction studies identified peripheral neuropathy affecting the median, ulnar and radial nerves. There was no evidence of entrapment neuropathy and the findings were attributed to nerve ischemia as a result of the steal phenomenon. This case represents an unusual complication of an AVM of the upper limb which has not been reported previously to our knowledge. Patients with complex AVMs presenting with atypical peripheral neuropathies should be assessed for the possibility of steal phenomenon.Level of Evidence: Level V, risk/prognostic study. 相似文献
993.
Setor K. Kunutsor Michael R. Whitehouse Ashley W. Blom Tim Board Peter Kay B. Mike Wroblewski Valérie Zeller Szu-Yuan Chen Pang-Hsin Hsieh Bassam A. Masri Amir Herman Jean-Yves Jenny Ran Schwarzkopf John-Paul Whittaker Ben Burston Ronald Huang Camilo Restrepo Javad Parvizi Sergio Rudelli Emerson Honda David E. Uip Guillem Bori Ernesto Muñoz-Mahamud Elizabeth Darley Alba Ribera Elena Cañas Javier Cabo José Cordero-Ampuero Maria Luisa Sorlí Redó Simon Strange Erik Lenguerrand Rachael Gooberman-Hill Jason Webb Alasdair MacGowan Paul Dieppe Matthew Wilson Andrew D. Beswick The Global Infection Orthopaedic Management Collaboration 《European journal of epidemiology》2018,33(10):933-946
One-stage and two-stage revision strategies are the two main options for treating established chronic peri-prosthetic joint infection (PJI) of the hip; however, there is uncertainty regarding which is the best treatment option. We aimed to compare the risk of re-infection between the two revision strategies using pooled individual participant data (IPD). Observational cohort studies with PJI of the hip treated exclusively by one- or two-stage revision and reporting re-infection outcomes were retrieved by searching MEDLINE, EMBASE, Web of Science, The Cochrane Library, and the WHO International Clinical Trials Registry Platform; as well as email contact with investigators. We analysed IPD of 1856 participants with PJI of the hip from 44 cohorts across four continents. The primary outcome was re-infection (recurrence of infection by the same organism(s) and/or re-infection with a new organism(s)). Hazard ratios (HRs) for re-infection were calculated using Cox proportional frailty hazards models. After a median follow-up of 3.7 years, 222 re-infections were recorded. Re-infection rates per 1000 person-years of follow-up were 16.8 (95% CI 13.6–20.7) and 32.3 (95% CI 27.3–38.3) for one-stage and two-stage strategies respectively. The age- and sex-adjusted HR of re-infection for two-stage revision was 1.70 (0.58–5.00) when compared with one-stage revision. The association remained consistently absent after further adjustment for potential confounders. The HRs did not vary importantly in clinically relevant subgroups. Analysis of pooled individual patient data suggest that a one-stage revision strategy may be as effective as a two-stage revision strategy in treating PJI of the hip. 相似文献
994.
Richard J. Rodenburg 《Journal of inherited metabolic disease》2018,41(3):297-307
Currently, one of the main challenges in human molecular genetics is the interpretation of rare genetic variants of unknown clinical significance. A conclusive diagnosis is of importance for the patient to obtain certainty about the cause of the disease, for the clinician to be able to provide optimal care to the patient and to predict the disease course, and for the clinical geneticist for genetic counseling of the patient and family members. Conclusive evidence for pathogenicity of genetic variants is therefore crucial. This review gives an introduction to the problem of the interpretation of genetic variants of unknown clinical significance in view of the recent advances in genetic screening, and gives an overview of the possibilities for functional tests that can be performed to answer questions about the function of genes and the functional consequences of genetic variants (“functional genomics”) in the field of inborn errors of metabolism (IEM), including several examples of functional genomics studies of mitochondrial disorders and several other IEM. 相似文献
995.
996.
C. Uleer B. Alt-Epping E. Wight B. van Oorschot N. Bock T. Dauelsberg A. D. Rose M. Gebhardt R. Tholen K. Paradies 《Der Gyn?kologe》2018,51(12):1037-1046
In April 2018 the first German interdisciplinary S3 guideline for the diagnostics, treatment, and follow-up of patients with endometrial cancer was published. This article is a summary of Chap. 9 on “Surveillance/Recurrence/Metastases of Endometrial Cancer” and is a clinically oriented abbreviated version, which includes recommendations for investigation modalities in aftercare and treatment options in cases of recurrence. Also included are aspects of psycho-oncological support and palliative medical care from the S3 guideline. 相似文献
997.
998.
Hagen Bomberg Thomas Volk Heinrich V. Groesdonk Andreas Meiser 《Journal of clinical monitoring and computing》2018,32(4):615-622
The circle system has been in use for more than a 100 years, whereas the first clinical application of an anaesthetic reflector was reported just 15 years ago. Its functional basis relies on molecular sieves such as zeolite crystals or activated carbon. In a circle system, the breathing gas is rebreathed after carbon dioxide absorption; a reflector on the other hand specifically retains the anaesthetic during expiration and resupplies it during the next inspiration. Reflection systems can be used in conjunction with intensive care ventilators and do not need the permanent presence of trained qualified staff. Because of easy handling and better ventilatory capabilities of intensive care ventilators, reflection systems facilitate the routine use of volatile anaesthetics in intensive care units. Until now, there are three reflection systems commercially available: the established AnaConDa? (Sedana Medical, Uppsala, Sweden), the new smaller AnaConDa-S?, and the Mirus? (Pall Medical, Dreieich, Germany). The AnaConDa consists only of a reflector which is connected to a syringe pump for infusion of liquid sevoflurane or isoflurane. The Mirus represents a technical advancement; its control unit includes a gas and ventilation monitor as well as a gas dispensing unit. The functionality, specific features, advantages and disadvantages of both systems are discussed in the text. 相似文献
999.
1000.
The application of tranexamic acid (TXA) in total joint arthroplasty has dramatically improved peri-operative blood management. In light of these benefits, a study by Huang et al., “Intravenous and Topical Tranexamic Acid Alone Are Superior to Tourniquet Use for Primary Total Knee Arthroplasty,” evaluates the need for continued use of the intra-operative tourniquet, which remains a routine practice with documented benefits and adverse effects. This review evaluates the study’s design and critically interprets its findings for clinical practice. Through a prospective, randomized trial, Huang et al. demonstrated that among selected patients undergoing primary total knee arthroplasty, the use of a tourniquet results in no reduction in blood loss beyond that provided by TXA alone. Moreover, the use of TXA without a tourniquet led to improved early clinical outcomes such as reduced post-operative swelling, improved knee range of motion at discharge, and enhanced patient satisfaction. As medicine is practiced in an increasingly value-driven environment, this study provides a useful method for evaluating the utility of commonly used interventions. Its findings highlight the need for future investigations into the optimal administration of TXA in total knee arthroplasty. 相似文献