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Background
The Shoulder Pain and Disability Index (SPADI) is a self-report measure developed to evaluate patients with shoulder pathology. While some validation has been conducted, broader analyses are indicated. This study determined aspects of cross-sectional and longitudinal validity of the SPADI. 相似文献13.
Ralph Madeb Dragan Golijanin Joy Knopf Craig Nicholson Stuart Cramer Frederick Tonetti Kelly Piccone John R. Valvo Louis Eichel 《Journal of robotic surgery》2007,1(2):145-149
Several recent studies have suggested that thought leaders in radical prostatectomy have decreased their own positive margin
rates by switching from open to robot-assisted radical prostatectomy. Theoretically, this improvement is largely attributed
to enhanced visualization of the deep pelvis and precision of dissection afforded by the instrumentation. To date, it has
not been determined if this phenomenon exists amongst non-fellowship-trained urologists in private practice. Herein, we describe
the positive margin rates of two non-fellowship-trained private-practice urologists who converted from open radical retropubic
prostatectomy to robot-assisted radical prostatectomy. The margin positivity data from two non-fellowship-trained private-practice
urologists (surgeon 1 and surgeon 2) were reviewed retrospectively. The last 50 cases of open radical retropubic prostatectomy
from each surgeon were compared with the first 50 robotic prostatectomy cases of surgeons 1 and 2, respectively. A positive
surgical margin was defined as tumor present at the inked margin of the prostate. There was a significant decrease in the
overall and pT2 positive margin rates for both surgeons. The overall positive margin rate and pT2 positive margin rate for
surgeon 1 dropped from 44 to 20% and from 37 to 5.7%, respectively, after changing from open to robotic prostatectomy. For
surgeon 2, the overall positive margin rate changed from 26 to 18% and the pT2 positive margin rate changed from 27.5 to 7%
after converting. Changing from open to robotic-assisted radical prostatectomy may improve the ability of urologists to obtain
negative surgical margins. With proper training this phenomenon does seem to apply to non-fellowship-trained urologists in
private practice and can be realized within the first 50 cases performed. 相似文献
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Edward L. Morgan Brandon N. Morgan Elisabeth A. Stein Elizabeth L. Vitrs Marilyn L. Thoman Sam D. Sanderson Joy A. Phillips 《Vaccine》2009
A conformationally biased, agonist of human C5a65–74 (EP67) was assessed for its adjuvant activities in vitro and in vivo. EP67 induced the release of the inflammatory (Th1) type cytokines from C5a receptor (CD88)-bearing antigen presenting cells (APC). EP67 did not induce the release of these cytokines from splenic APCs obtained from C5a receptor knockouts (CD88−/−). Serum from mice immunized with EP67–ovalbumin (OVA) contained high OVA-specific antibody (Ab) titers [IgG1, IgG2a (IGg2c), IgG2b]. Mice receiving OVA alone produced only IgG1 Abs, indicating the ability of EP67 to induce a Th1-like Ab class switch. Spleen cell cultures from wild type mice but not CD88−/− mice showed an enhanced OVA-specific proliferative response in vitro. These results indicate the ability of EP67 to drive a Th1-mediated immune response and its potential use as a unique adjuvant. 相似文献
16.
Dorian Deshauer Anne Duffy Martin Alda Eva Grof Joy Albuquerque Paul Grof 《Revue canadienne de psychiatrie》2003,48(7):462-466
OBJECTIVE: A growing body of data suggests that a significantly enhanced salivary cortisol response to waking may indicate an enduring tendency to abnormal cortisol regulation. Our objective was to apply the response test to a population already known to have long-term hypothalamo-pituitary-adrenocortical (HPA) axis dysregulation. We hypothesized that the free cortisol response to waking, believed to be genetically influenced, would be elevated in a significant percentage of cases, regardless of the afternoon Dexamethasone Suppression Test (DST) value. METHOD: Using the free cortisol response to waking and the short daytime profile, we tested 18 clinically stable, lithium-responsive subjects from our long-term naturalistic follow-up of monthly DSTs. These tests include salivary testing every 15 minutes during the first hour of waking, followed by samples taken at 3:00 PM and 8:00 PM. RESULTS: While clinically stable on lithium prophylaxis, patients with bipolar disorder (BD) showed a significantly enhanced salivary cortisol response to waking, compared with control subjects (P < 0.03). Cortisol levels 30 minutes after waking significantly exceeded those in the large normative data provided in the literature (P < 0.001). CONCLUSIONS: Our observations support the hypothesis that the free cortisol response to waking can reflect relatively enduring HPA dysregulation, even when lithium-responsive BD patients are clinically well and their DSTs are normal. Because the test is easy to administer, the free cortisol response to waking may hold promise as a marker in studies of high-risk families predisposed to, or at risk for, mood disorders. 相似文献
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R A Lubet R W Nims E Kiss R E Kouri D L Putman L M Schechtman 《Environmental mutagenesis》1986,8(4):533-542
Several of the major variable factors in the Syrian hamster embryo/simian adenovirus SA7 (SHE/SA7) viral enhancement assay were identified and the effects of these parameters on assay sensitivity were assessed. The extent of dose-dependent cytotoxicity and enhancement of SA7 transformation of primary SHE target cells by benzo(a)pyrene was examined through analysis of data obtained from 37 assays performed over a 2-year period. The variables analyzed for contribution to assay sensitivity included the number of SA7-induced transformed SHE cell foci enumerated in ten replicate dishes in the negative control condition (background focus count) (range: 26-139); the age of the SHE cell cultures at the time of exposure to benzo(a)pyrene (range: 72-144 hr postseeding); and the source of the pregnant hamsters used to prepare the primary SHE cells (Wilmington colony vs Lakeview colony, Charles River Laboratories, Inc., Wilmington, MA). The benzo(a)pyrene-induced cytotoxicity and enhancement of SA7 transformation responses were found to be independent of each of these variables, within the range of values tested. 相似文献
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