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101.
Sluijs I Forouhi NG Beulens JW van der Schouw YT Agnoli C Arriola L Balkau B Barricarte A Boeing H Bueno-de-Mesquita HB Clavel-Chapelon F Crowe FL de Lauzon-Guillain B Drogan D Franks PW Gavrila D Gonzalez C Halkjaer J Kaaks R Moskal A Nilsson P Overvad K Palli D Panico S Quirós JR Ricceri F Rinaldi S Rolandsson O Sacerdote C Sánchez MJ Slimani N Spijkerman AM Teucher B Tjonneland A Tormo MJ Tumino R van der A DL Sharp SJ Langenberg C Feskens EJ Riboli E Wareham NJ;InterAct Consortium 《The American journal of clinical nutrition》2012,96(2):382-390
102.
Draine J Ahuja D Altice FL Arriola KJ Avery AK Beckwith CG Booker CA Ferguson A Figueroa H Lincoln T Ouellet LJ Porterfield J Spaulding AC Tinsley MJ 《AIDS care》2011,23(3):366-377
The policies of mass incarceration and the expansion of the criminal justice system in the USA over the last 40 years have weighed heavily on individuals and communities impacted by drug use and HIV disease. Though less than ideal, jails provide a unique opportunity to diagnose, treat and implement effective interventions. The role of jails in HIV detection, treatment, and continuity of care, however, has yet to be systematically examined. This paper reviews the service strategies and contexts for 10 demonstration sites funded to develop innovative methods for providing care and treatment to HIV-infected individuals in jail settings who are returning to their communities. The sites have implemented varied intervention strategies; each set in unique policy and service system contexts. Collaboration among agencies and between systems to implement these interventions is viewed as particularly challenging undertakings. We anticipate the sites will collectively serve 700-1000 individuals across the duration of the initiative. In this paper, we review the service contexts and strategies developed by the 10 sites. The individual and multi-site evaluations aim to provide new data on testing, treatment, and community linkages from jails that will further develop our knowledge base on effective intervention strategies in these settings. 相似文献
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Mie Topholm Bruun Mark H. Yazer Philip C. Spinella Kjell Titlestad Miquel Lozano Meghan Delaney Hana Lejdarov Dana Pavlova Pavel Trakhtman Nikolay Starostin Eugene Zhiburt Marian G. J. van Kraaij Elise Huisman Jose M. Kutner Araci M. Sakashita Ana P. H. Yokoyama Josune Zubicaray Julin Sevilla Hitoshi Okazaki Mitsuteru Hiwatari Yutaka Nagura Paola Maria Manzini Giuseppina Facco Clara Pecoraro Lakhvinder Singh Rekha Hans Ratti Ram Sharma Praveen Kumar Agneta Wikman Emke Deschmann Hartirathpal Kaur Joyce Ching Mei Lam Selina Kah Ying Ho Pei Lin Koh Rachel Moss Helen V. New Anne Kinmonth Mary Comande Helen Savoia Gemma Crighton Joanne Yacobovich Vered Yahalom Wendy Lau 《Vox sanguinis》2019,114(5):e36-e90
105.
Vox Sanguinis International Forum on paediatric indications for blood component transfusion: Summary
Mie Topholm Bruun Mark H. Yazer Philip C. Spinella Kjell Titlestad Miquel Lozano Meghan Delaney Hana Lejdarov Dana E. Pavlova Pavel Trakhtman Nikolay Starostin Eugene Zhiburt Marian G. J. van Kraaij Elise Huisman Jose M. Kutner Araci M. Sakashita Ana P. H. Yokoyama Josune Zubicaray Julin Sevilla Hitoshi Okazaki Mitsuteru Hiwatari Yutaka Nagura Paola Maria Manzini Giuseppina Facco Costantino Avdis Lakhvinder Singh Rekha Hans Ratti Ram Sharma Praveen Kumar Agneta Wikman Emke Deschmann Hartirathpal Kaur Joyce Lam Ching Mei Selina Ho Kah Ying Koh Pei Lin Helen V. New Rachel Moss Anne Kinmonth Mary Comande Helen Savoia Gemma Crighton Joanne Yacobovich Vered Yahalom Wendy Lau 《Vox sanguinis》2019,114(5):523-530
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Emily Russell Michael R. Kramer Hannah L. F. Cooper Winifred Wilkins Thompson Kimberly R. Jacob Arriola 《Journal of urban health》2011,88(6):1117-1129
We explored the association between neighborhood residential racial composition and breast cancer mortality among Black and
White breast cancer patients in Georgia and whether spatial access to cancer care mediates this association. Participants
included 15,256 women living in 15 metropolitan statistical areas in Georgia who were diagnosed with breast cancer between
1999 and 2003. Residential racial composition was operationalized as the percent of Black residents in the census tract. We
used gravity-based modeling methods to ascertain spatial access to oncology care. Multilevel Cox proportional hazards models
and mediation analyses were used to test associations. Black women were 1.5 times more likely to die from breast cancer than
White women. Residential racial composition had a small but significant association with breast cancer mortality (hazard ratios
[HRs] = 1.04–1.08 per 10% increase in the percent of Black tract residents). Individual race did not moderate this relationship,
and spatial access to care did not mediate it. Residential racial composition may be part of the socioenvironmental milieu
that produces increased breast cancer mortality among Black women. However, there is a lack of evidence that spatial access
to oncology care mediates these processes. 相似文献
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Arriola E Marchio C Tan DS Drury SC Lambros MB Natrajan R Rodriguez-Pinilla SM Mackay A Tamber N Fenwick K Jones C Dowsett M Ashworth A Reis-Filho JS 《Laboratory investigation; a journal of technical methods and pathology》2008,88(5):491-503
HER2 and TOP2A are targets for the therapeutic agents trastuzumab and anthracyclines and are frequently amplified in breast cancers. The aims of this study were to provide a detailed molecular genetic analysis of the 17q12-q21 amplicon in breast cancers harbouring HER2/TOP2A co-amplification and to investigate additional recurrent co-amplifications in HER2/TOP2A-co-amplified cancers. In total, 15 breast cancers with HER2 amplification, 10 of which also harboured TOP2A amplification, as defined by chromogenic in situ hybridisation, and 6 breast cancer cell lines known to be amplified for HER2 were subjected to high-resolution microarray-based comparative genomic hybridisation analysis. This revealed that the genomes of 12 cases were characterised by at least one localised region of clustered, relatively narrow peaks of amplification, with each cluster confined to a single chromosome arm (ie 'firestorm' pattern) and 3 cases displayed many narrow segments of duplication and deletion affecting the vast majority of chromosomes (ie 'sawtooth' pattern). The smallest region of amplification (SRA) on 17q12 in the whole series extended from 34.73 to 35.48 Mb, and encompassed HER2 but not TOP2A. In HER2/TOP2A-co-amplified samples, the SRA extended from 34.73 to 36.54 Mb, spanning a region of approximately 1.8 Mb. Apart from HER2 and TOP2A, this region encompassed four additional genes whose expression levels as defined by quantitative real-time PCR are significantly higher in HER2/TOP2A-co-amplified vs HER2-amplified breast cancers: CASC3, CDC6, RARA and SMARCE1. Of the cell lines studied, SKBR3 and UACC812 showed HER2/TOP2A co-amplification. In conclusion, this is the first detailed genome-wide characterisation of HER2/TOP2A-amplified breast cancers; cell lines were identified that can be used to model these cancers in vitro. The 17q12 amplicon is complex and harbours multiple genes that may be associated with breast cancer development and progression, and potentially exploitable as therapeutic targets. 相似文献