全文获取类型
收费全文 | 22072篇 |
免费 | 1385篇 |
国内免费 | 113篇 |
专业分类
耳鼻咽喉 | 287篇 |
儿科学 | 480篇 |
妇产科学 | 461篇 |
基础医学 | 2727篇 |
口腔科学 | 731篇 |
临床医学 | 1854篇 |
内科学 | 5613篇 |
皮肤病学 | 499篇 |
神经病学 | 1829篇 |
特种医学 | 511篇 |
外科学 | 3672篇 |
综合类 | 142篇 |
一般理论 | 8篇 |
预防医学 | 1414篇 |
眼科学 | 629篇 |
药学 | 1205篇 |
1篇 | |
中国医学 | 53篇 |
肿瘤学 | 1454篇 |
出版年
2023年 | 157篇 |
2022年 | 313篇 |
2021年 | 739篇 |
2020年 | 390篇 |
2019年 | 660篇 |
2018年 | 803篇 |
2017年 | 478篇 |
2016年 | 528篇 |
2015年 | 667篇 |
2014年 | 900篇 |
2013年 | 1096篇 |
2012年 | 1821篇 |
2011年 | 1872篇 |
2010年 | 1001篇 |
2009年 | 902篇 |
2008年 | 1441篇 |
2007年 | 1524篇 |
2006年 | 1409篇 |
2005年 | 1263篇 |
2004年 | 1080篇 |
2003年 | 945篇 |
2002年 | 850篇 |
2001年 | 161篇 |
2000年 | 148篇 |
1999年 | 199篇 |
1998年 | 197篇 |
1997年 | 155篇 |
1996年 | 139篇 |
1995年 | 143篇 |
1994年 | 130篇 |
1993年 | 125篇 |
1992年 | 121篇 |
1991年 | 91篇 |
1990年 | 94篇 |
1989年 | 81篇 |
1988年 | 63篇 |
1987年 | 64篇 |
1986年 | 63篇 |
1985年 | 45篇 |
1984年 | 78篇 |
1983年 | 63篇 |
1982年 | 66篇 |
1981年 | 68篇 |
1980年 | 41篇 |
1979年 | 48篇 |
1978年 | 39篇 |
1977年 | 36篇 |
1975年 | 27篇 |
1974年 | 29篇 |
1973年 | 32篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
131.
Eduardo Palomares Jos C. Bellido Angel L. Morales Antonio J. Nieto Jose M. Chicharro Publio Pintado 《Optimal control applications & methods.》2021,42(1):216-235
This article presents an optimal control strategy (OCS) for semiactive vehicle suspensions with road profile sensors. The suspension is modeled as a quarter‐car model with a magnetorheological (MR) damper. The OCS main objective is to minimize the fourth‐power acceleration of the sprung mass. In addition, three pointwise constraints of the model are taken into account when the optimal control problem is solved: suspension travel limits (upper and lower) and tyre vertical force. In order to deal with a large number of constraints, we implement the gradient optimization method based on the method of moving asymptotes routine, which shows very good performance reaching optimal controls while satisfying the constrains. The solution has been compared with two passive MR damper configurations (low and high damping) as well as Skyhook and Balance control strategies for three different road inputs. Results show that OCS fulfills the constraints and reduces the sprung mass acceleration peak and the root‐mean‐quad acceleration up to 59% , in comparison to passive strategies. 相似文献
132.
133.
Ghazal Arabidarrehdor Ali Tivay Ramin Bighamian Chris Meador George C. Kramer Jin-Oh Hahn Jose Salinas 《Burns : journal of the International Society for Burn Injuries》2021,47(2):371-386
This paper presents a mathematical model of blood volume kinetics and renal function in response to burn injury and resuscitation, which is applicable to the development and non-clinical testing of burn resuscitation protocols and algorithms. Prior mathematical models of burn injury and resuscitation are not ideally suited to such applications due to their limited credibility in predicting blood volume and urinary output observed in wide-ranging burn patients as well as in incorporating contemporary knowledge of burn pathophysiology. Our mathematical model consists of an established multi-compartmental model of blood volume kinetics, a hybrid mechanistic-phenomenological model of renal function, and novel lumped-parameter models of burn-induced perturbations in volume kinetics and renal function equipped with contemporary knowledge on burn-related physiology and pathophysiology. Using the dataset collected from 16 sheep, we showed that our mathematical model can be characterized with physiologically plausible parameter values to accurately predict blood volume kinetic and renal function responses to burn injury and resuscitation on an individual basis against a wide range of pathophysiological variability. Pending validation in humans, our mathematical model may serve as an effective basis for in-depth understanding of complex burn-induced volume kinetic and renal function responses as well as development and non-clinical testing of burn resuscitation protocols and algorithms. 相似文献
134.
135.
136.
137.
138.
M. Dolores del Toro López Javier Arias Díaz José M. Balibrea Natividad Benito Andrés Canut Blasco Erika Esteve Juan Pablo Horcajada Juan Diego Ruiz Mesa Alba Manuel Vázquez Cristóbal Muñoz Casares Jose Luis del Pozo Miquel Pujol Melchor Riera Jaime Jimeno Inés Rubio Pérez Jaime Ruiz-Tovar Polo Alejandro Serrablo Alex Soriano Josep M. Badia 《Cirugía espa?ola》2021,99(1):11-26
Antibiotic prophylaxis in surgery is one of the most effective measures for preventing surgical site infection, although its use is frequently inadequate and may even increase the risk of infection, toxicities and antimicrobial resistance. As a result of advances in surgical techniques and the emergence of multidrug-resistant organisms, the current guidelines for prophylaxis need to be revised.The Sociedad Española de Enfermedades Infecciosas (Spanish Society of Infectious Diseases and Clinical Microbiology) (SEIMC) together with the Asociación Española de Cirujanos (Spanish Association of Surgeons) (AEC) have revised and updated the recommendations for antibiotic prophylaxis in surgery to adapt them to any type of surgical intervention and to current epidemiology. This document gathers together the recommendations on antimicrobial prophylaxis in the various procedures, with doses, duration, prophylaxis in special patient groups, and in epidemiological settings of multidrug resistance to facilitate standardized management and the safe, effective and rational use of antibiotics in elective surgery. 相似文献
139.
Ignacio Aguirre-Allende Jose Maria Enriquez-Navascues Garazi Elorza-Echaniz Ane Etxart-Lopetegui Nerea Borda-Arrizabalaga Yolanda Saralegui Ansorena Carlos Placer-Galan 《Cirugía espa?ola》2021,99(2):89-107
Local excision (LE) has arisen as an alternative to total mesorectal excision for the treatment of early rectal cancer. Despite a decreased morbidity, there are still concerns about LE outcomes.This systematic-review and meta-analysis design is based on the “PICO” process, aiming to answer to three questions related to LE as primary treatment for early-rectal cancer, the optimal method for LE, and the potential role for completion treatment in high-risk histology tumors and outcomes of salvage surgery.The results revealed that reported overall survival (OS) and disease-specific survival (DSS) were 71%–91.7% and 80%–94% for LE, in contrast to 92.3%–94.3% and 94.4%–97% for radical surgery. Additional analysis of National Database studies revealed lower OS with LE (HR: 1.26; 95%CI, 1.09–1.45) and DSS (HR: 1.19; 95%CI, 1.01–1.41) after LE. Furthermore, patients receiving LE were significantly more prone develop local recurrence (RR: 3.44, 95%CI, 2.50–4.74). Analysis of available transanal surgical platforms was performed, finding no significant differences among them but reduced local recurrence compared to traditional transanal LE (OR:0.24;95%CI, 0.15–0.4). Finally, we found poor survival outcomes for patients undergoing salvage surgery, favoring completion treatment (chemoradiotherapy or surgery) when high-risk histology is present.In conclusion, LE could be considered adequate provided a full-thickness specimen can be achieved that the patient is informed about risk for potential requirement of completion treatment. Early-rectal cancer cases should be discussed in a multidisciplinary team, and patient's preferences must be considered in the decision-making process. 相似文献
140.
Shylaja Srinivasan Ling Chen Jennifer Todd Jasmin Divers Samuel Gidding Steven Chernausek Rose A. Gubitosi-Klug Megan M. Kelsey Rachana Shah Mary Helen Black Lynne E. Wagenknecht Alisa Manning Jason Flannick Giuseppina Imperatore Josep M. Mercader Dana Dabelea Jose C. Florez 《Diabetes》2021,70(4):996
The prevalence of type 2 diabetes in youth has increased substantially, yet the genetic underpinnings remain largely unexplored. To identify genetic variants predisposing to youth-onset type 2 diabetes, we formed ProDiGY, a multiethnic collaboration of three studies (TODAY, SEARCH, and T2D-GENES) with 3,006 youth case subjects with type 2 diabetes (mean age 15.1 ± 2.9 years) and 6,061 diabetes-free adult control subjects (mean age 54.2 ± 12.4 years). After stratifying by principal component–clustered ethnicity, we performed association analyses on ∼10 million imputed variants using a generalized linear mixed model incorporating a genetic relationship matrix to account for population structure and adjusting for sex. We identified seven genome-wide significant loci, including the novel locus rs10992863 in PHF2 (P = 3.2 × 10−8; odds ratio [OR] = 1.23). Known loci identified in our analysis include rs7903146 in TCF7L2 (P = 8.0 × 10−20; OR 1.58), rs72982988 near MC4R (P = 4.4 × 10−14; OR 1.53), rs200893788 in CDC123 (P = 1.1 × 10−12; OR 1.32), rs2237892 in KCNQ1 (P = 4.8 × 10−11; OR 1.59), rs937589119 in IGF2BP2 (P = 3.1 × 10−9; OR 1.34), and rs113748381 in SLC16A11 (P = 4.1 × 10−8; OR 1.04). Secondary analysis with 856 diabetes-free youth control subjects uncovered an additional locus in CPEB2 (P = 3.2 × 10−8; OR 2.1) and consistent direction of effect for diabetes risk. In conclusion, we identified both known and novel loci in the first genome-wide association study of youth-onset type 2 diabetes. 相似文献