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11.
Joline W. J. Beulens Heidi P. Fransen Ellen A. Struijk Jolanda M. A. Boer G. Ardine de Wit N. Charlotte Onland-Moret Jeljer Hoekstra H. Bas Bueno-de-Mesquita Anne M. May 《European journal of epidemiology》2017,32(4):317-326
The relation of alcohol consumption with disease burden remains debated partly due to opposite associations with cardiovascular disease (CVD) and cancer. The relation of alcohol consumption with disease burden expressed in disability-adjusted life years (DALYs) summarizes opposing associations of alcohol consumption on chronic diseases. This study aimed to investigate the association of alcohol consumption with chronic disease burden expressed in DALYs based on individual-participant data. The study was a prospective study among 33,066 men and women from the EPIC-NL cohort. At baseline, alcohol consumption was assessed with a validated food-frequency questionnaire. Participants were followed for occurrence of and mortality from chronic diseases and DALYs were calculated. After 12.4 years follow-up, 6647 disease incidences and 1482 deaths were documented, resulting in 68,225 healthy years of life lost (6225 DALYs). Moderate drinkers (women 5–14.9 g/day, men 5–29.9 g/day) had a lower chronic disease burden (mean DALYs ?0.27; 95% CI ?0.43; ?0.11) than light drinkers (0–4.9 g/day), driven by a lower disease burden due to CVD (?0.18: ?0.29; ?0.06) but not cancer (?0.05: ?0.16; 0.06). The associations were most pronounced among older participants (≥50 years; ?0.32; ?0.53; ?0.10) and not observed among younger women (?0.08; ?0.43; 0.35), albeit non-significant (pinteraction > 0.14). Substantial drinking (women 15–29.9 g/day, men 30–59.9 g/day) compared to light drinking was not associated with chronic disease burden. Our results show that moderate compared to light alcohol consumption was associated with living approximately 3 months longer in good health. These results were mainly observed among older participants and not seen among younger women. 相似文献
12.
Rio P. Juni Rushd Al-Shama Diederik W.D. Kuster Jolanda van der Velden Henrike M. Hamer Marc G. Vervloet Etto C. Eringa Pieter Koolwijk Victor W.M. van Hinsbergh 《Kidney international》2021,99(5):1088-1101
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13.
Salvatore De Rosa Francesca Eposito Cristina Carella Antonio Strangio Giuseppe Ammirati Jolanda Sabatino Fabio Giovanni Abbate Claudio Iaconetti Vincenzo Liguori Valerio Pergola Alberto Polimeni Silvio Coletta Clarice Gareri Bruno Trimarco Giuseppe Stabile Antonio Curcio Ciro Indolfi Antonio Rapacciuolo 《European journal of heart failure》2018,20(6):1000-1010
Aims
Circulating levels of microRNAs (miRNAs) are emergent promising biomarkers for cardiovascular disease. Altered expression of miRNAs has been related to heart failure (HF) and cardiac remodelling. We measured the concentration gradients across the coronary circulation to assess their usefulness to diagnose HF of different aetiologies.Methods and results
Circulating miRNAs were measured in plasma samples simultaneously obtained from the aorta and the coronary venous sinus in patients with non‐ischaemic HF (NICM‐HF, n = 23) ischaemic HF (ICM‐HF, n = 41), and in control patients (n = 11). A differential modulation of circulating levels of miR‐423, ‐34a, ‐21‐3p, ‐126, ‐199 and ‐30a was found across the aetiology groups. Interestingly, a positive transcoronary gradient was found for miR‐423 (P < 0.001) and miR‐34a (P < 0.001) only in the ICM‐HF group. On the contrary, a positive gradient was found for miR‐21‐3p (P < 0.001) and miR‐30a (P = 0.030) only in the NICM‐HF group. Finally, no significant variations were observed in the transcoronary gradient of miR‐126 or miR‐199.Conclusions
The present findings suggest that circulating levels of miRNAs are differentially expressed in patients with HF of different aetiologies. The presence of a transcoronary concentration gradient suggests a selective release of miRNAs by the failing heart into the coronary circulation. The presence of aetiology‐specific transcoronary concentration gradients in HF patients might provide important information to better understand their role in HF, and suggests they could be useful biomarkers to distinguish HF of different aetiologies.14.
15.
Social Role Participation and Satisfaction With Life: A Study Among Patients With Ankylosing Spondylitis and Population Controls
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Simon van Genderen Guy Plasqui Désirée van der Heijde Floris van Gaalen Liesbeth Heuft Jolanda Luime Anneke Spoorenberg Suzanne Arends Diane Lacaille Monique Gignac Robert Landewé Annelies Boonen 《Arthritis care & research》2018,70(4):600-607
Objective
Participation in society of persons with chronic diseases receives increasing attention. However, little is known about which components of participation are most relevant to life satisfaction. This study examines the association between several aspects of social role participation and satisfaction with life (SWL) in patients with ankylosing spondylitis (AS) compared to population controls.Methods
In a cross‐sectional study, participants completed the Social Role Participation Questionnaire (SRPQ) and SWL scale. The SRPQ assesses several dimensions of participation (importance, satisfaction with performance, and satisfaction with time and physical difficulty) in 11 roles representing 3 domains (interpersonal relations, leisure, and work). For individuals with AS and controls, the association between role domains and SWL was examined using linear regression for each participation dimension separately, in the total and the employed population, adjusting for age, sex, education, and income.Results
A total of 246 AS patients (mean ± SD age 51 ± 12 years, 62% males, mean ± SD disease duration 17 ± 12 years) and 510 controls (mean ± SD age 42 ± 15 years, 70% males) were included. AS patients were more frequently (extremely) dissatisfied with life (17.9% versus 8.6%; P < 0.05). In the total and the employed population, less physical difficulty and higher satisfaction with interpersonal relations and leisure were associated with higher SWL, and this was somewhat stronger in patients than in controls (P < 0.1). In employed controls, but not in employed patients, satisfaction with work was independently associated with SWL.Conclusion
These findings highlight the importance of supporting persons with AS in ameliorating social role participation, particularly in areas like close relationships and leisure activities, which are typically ignored when treating AS.16.
17.
Rothkrantz-Kos S Drent M Rutgers A Heeringa P De Vries J van Dieijen-Visser MP Cohen Tervaert JW 《European Journal of Internal Medicine》2003,14(5):296-301
Previously, we demonstrated that the number of polymorphonuclear neutrophils (PMNs) in bronchoalveolar lavage fluid (BALF) is useful in distinguishing sarcoidosis patients with a favorable outcome from those having a more severe course of disease. Neutrophils contain the oxidant-generating enzyme myeloperoxidase (MPO). Cellular levels of MPO can be influenced by functional promotor polymorphisms, ?463G/A and ?129G/A, which may modify disease severity. 相似文献
18.
Heijckmann AC Huijberts MS Geusens P de Vries J Menheere PP Wolffenbuttel BH 《European journal of endocrinology / European Federation of Endocrine Societies》2005,153(1):23-29
OBJECTIVE: Untreated hyperthyroidism and treatment with high doses of thyroid hormone are associated with osteoporosis. However, their effect on bone turnover, their contribution to bone mineral density (BMD) in the context of other clinical risk factors for osteoporosis and the prevalence of vertebral fractures is not well documented. DESIGN: Cross-sectional study. METHODS: We studied 59 patients receiving L-thyroxine suppressive therapy for differentiated thyroid carcinoma (DTC). BMD of the hip was measured by dual X-ray absorptiometry (DXA) and lateral DXA pictures of the lumbar and thoracic vertebrae were performed. Bone resorption was measured by C-telopeptides of type I collagen (ICTP) and bone formation by procollagen type I N-propeptide (PINP). Clinical risk factors for osteoporosis were evaluated using a questionnaire. RESULTS: Z-scores of BMD were similar as the NHANES (National Health and Nutrition Examination Survey) III reference group in women and men, also after long-term (> 10 years) suppression therapy. Patients in the lowest and highest quartile of BMD showed significant differences in the presence of clinical risk factors. ICTP levels were significantly higher than in age-matched controls, PINP levels were not different. We found four patients with a prevalent vertebral fracture. CONCLUSIONS: We conclude that patients with well-differentiated thyroid carcinoma are not at increased risk of developing low bone mass nor have a higher prevalence of vertebral fracture at least when treated with relatively low doses of L-thyroxine. 相似文献
19.
Marie-Jeanne Aarts Jolanda J. P. Mathijssen Johannes A. M. van Oers Albertine J. Schuit 《International journal of behavioral medicine》2013,20(4):538-555
Background
Active commuting to school can contribute to active living among children, and environmental characteristics might be related to transportation mode to school.Purpose
The purpose of this study is to explore the association between physical and social environmental characteristics in the home, neighborhood, and school environment and walking and bicycling to school.Method
Data were collected among parents (n?=?5,963) of children of primary schools in four Dutch cities. Parents reported mode of transportation to school, and individual, home environmental, neighborhood, and school environmental characteristics. Social as well as physical characteristics were included for the home and neighborhood environment. Multilevel multinomial logistic regression analyses were conducted to quantify the association between environmental characteristics and walking and bicycling to school.Results
Three quarter of all children usually commute to school by active transportation, but age and distance from home to school were important prerequisites. Besides home environmental characteristics, lower neighborhood socioeconomic status was negatively associated with walking [odds ratio (OR)?=?0.51] and bicycling (OR?=?0.86). Perceived social safety was positively related to walking and bicycling (OR?=?1.04 for both), as was perceived social cohesion (OR?=?1.04 and 1.02 for walking and bicycling). Living in the city center was positively associated with walking (OR?=?1.91), whereas living in a city green neighborhood was negatively associated with walking and bicycling (OR?=?0.48 and 0.76, respectively). Traffic safety as perceived by school boards was positively associated with bicycling (OR?=?1.25).Conclusion
This study shows that there is a relation between several characteristics in the home, neighborhood, and school environment and walking and bicycling to school among Dutch primary school children. Especially the social neighborhood characteristics were related to active commuting. Therefore, apart from providing a physical infrastructure that facilitates safe and convenient active commuting to school, policy makers should be aware of opportunities to facilitate active commuting by social initiatives in local communities. 相似文献20.