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91.
Anoop Sheshadri Giuseppe Cullaro Kirsten L. Johansen Jennifer C. Lai 《Clinical transplantation》2020,34(6):e13848
Patients with end-stage renal disease (ESRD) have impaired functional status compared with the general population. We sought to explore the association between Karnofsky Performance Status (KPS) and death/delisting from the kidney transplantation waitlist and whether this association differed by age. Patients listed for single-organ kidney transplantation in the United Network for Organ Sharing/Organ Procurement and Transplantation Network from January 1, 2015, to January 1, 2018, were included. We performed competing-risk regression analyses to determine the association between KPS (“Severely impaired”, “Moderately impaired”, “Non-impaired”) and death/delisting, with deceased-donor kidney transplantation as a competing risk. We tested for interactions between age and KPS on death/delisting. Of the 89,819 patients analyzed, 39% were impaired (KPS < 80) and 20% were aged ≥ 65 years. Older age and lower KPS were independently associated with higher risk of death/delisting (age 45-64 years, HR 1.97 [95% CI 1.73-2.24]; age ≥ 65 years, HR 3.62 [95% CI 3.33-3.92] compared with age < 45 years; moderately impaired, HR 1.68 [95% CI 1.45-1.95]; severely impaired, HR 4.80 [95% CI 3.71-6.21] compared with non-impaired). Lower KPS was associated with higher risk of death/delisting among all ages, but this effect was slightly less pronounced among individuals aged ≥ 65 years. Performance status should be used when counseling patients with ESRD on their risks for death/delisting. 相似文献
92.
Mark W. Zawadsky Megan C. Paulus Patrick J. Murray Matthew A. Johansen 《The Journal of arthroplasty》2014
This study evaluated early postoperative results of 150 consecutive primary total hip arthroplasties performed by a single surgeon; 50 from mini-incision posterior approach, 50 during the learning curve for the direct anterior approach, and 50 subsequent cases when the approach was routine. The anterior approach groups had significantly reduced hospital length of stays (2.9 and 2.7 days versus 3.9 days for the posterior group; P < 0.0001) and discharge to home versus rehab was more likely (80% and 84% in anterior groups, 56% in posterior group; P = 0.0028). In the anterior groups, there was significantly less use of assistive devices and narcotics at 6 weeks, and pain was significantly lower. Primary total hip arthroplasty using the anterior approach allows for superior recovery in a matched cohort of patients. 相似文献
93.
Salmon Mandy K Hammer Karen Eich Nygaard Jens Vinge Korsholm Kasper Johansen Peter Nielsen-Kudsk Jens Erik 《Journal of interventional cardiac electrophysiology》2021,61(1):199-206
Journal of Interventional Cardiac Electrophysiology - Left atrial appendage occlusion (LAAO) involves a “tug test,” in which implanters pull on the device delivery cable to ensure... 相似文献
94.
Salmon Mandy K Hammer Karen Eich Nygaard Jens Vinge Korsholm Kasper Johansen Peter Nielsen-Kudsk Jens Erik 《Journal of interventional cardiac electrophysiology》2021,61(1):207-208
Journal of Interventional Cardiac Electrophysiology - For Fig. 4, an internal working draft of the image depicting the device placed in the heart was erroneously provided during the... 相似文献
95.
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97.
Dr. U. Wied M.D. T. Nilsson M.D. J. B. Knudsen M.D. M. Sprechler M.D. Aa. Johansen M.D. 《Diseases of the colon and rectum》1985,28(5):333-335
The association between histopathologic findings and postoperative survival in 442 patients with potentially curable carcinomas
of the colon has been analyzed using Cox's regression model. The prognostic variables included in the study were age, sex,
stage of disease according to Dukes' classification and Broders' grading, as well as presence/absence at the time of operation
of venous and nerve invasion. The overall five-year postoperative survival rate was 46.6 percent. Using a model including
all prognostic factors, sex and Dukes' classification were not found to be associated with survival. Broders' grading and/or
nerve invasion yielded only a borderline statistical significance in the model that included all factors. The invasion of
veins was almost always associated with invasion of nerves. 相似文献
98.
DNA strand breaks measured within 100 milliseconds of irradiation of Escherichia coli by 4 MeV electrons.
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I Johansen T Brustad W D Rupp 《Proceedings of the National Academy of Sciences of the United States of America》1975,72(1):167-171
A method was developed in which E. coli cells were irradiated with four MeV electrons and transferred to alkaline detergent within a fraction of a second. This technique minimizes the amount of repair of radiation damage before analysis without the necessity of using physical or chemical treatments to inhibit repair and alter the physiological condition of the cells. The yield of DNA strans breaks formed in covalent circular superhelical lambda DNA molecules superinfecting E. coli lysogens was about 4-fold greater when the cells were irradiated in oxygen than when they were irradiated under nitrogen anoxia. The same yields were obtained in phosphate buffer at 3 degrees and 22 degrees as well as in growth medium at 37 degrees, and the yields were not altered by the polA1 mutation. When E. coli lysogenic cells superinfected with lambda were irradiated with doses sufficient to introduce at least seven breaks in the phage DNA, the chromosomal DNA and the superinfecting phage DNA sedimented similarly in alkaline sucrose gradients, indicating that both DNAs were broken to a similar extent during irradiation. However, the yield of breaks calculated for chromosomal DNA in similar experiments was greater than the yield calculated from the first break introduced into covalent circular lambda DNA molecules. These apparently contradictory results are explicable either if the initial break in a superhelical molecule occurs with an efficiency different from that for subsequent breaks, or if the pulsed electron radiation produces a high proportion of double-strand breaks. 相似文献
99.
Knudsen LS Klarlund M Skjødt H Jensen T Ostergaard M Jensen KE Hansen MS Hetland ML Nielsen HJ Johansen JS 《The Journal of rheumatology》2008,35(7):1277-1287
OBJECTIVE: To determine plasma interleukin 6 (pIL-6), plasma vascular endothelial growth factor (pVEGF), and serum (s) YKL-40 in patients with early rheumatoid arthritis (RA) and unclassified polyarthritis (PA), and investigate their relationship with radiographic outcome. METHODS: pIL-6 and pVEGF were determined by ELISA and sYKL-40 by an in-house radioimmunoassay in 51 patients with early RA and 21 with PA. Patients were followed with clinical and biochemical measurement every month for 2 years. Conventional radiographs of hands, wrists, and forefeet were scored according to the Larsen method, and magnetic resonance imaging of 2nd to 5th metacarpophalangeal joints of the dominant hand were evaluated for presence or absence of bone erosions. RESULTS: Baseline pIL-6, pVEGF, sYKL-40, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were elevated in RA patients compared to healthy persons (p < 0.001), but were not in patients with PA. Patients with early RA had higher pIL-6 (p = 0.007), pVEGF (p = 0.02), and sYKL-40 (p = 0.024) compared to PA patients. pIL-6, sYKL-40, CRP, and ESR but not pVEGF decreased in patients that responded to treatment after 2 years. The mean value of pIL-6 during the first and second year were higher in patients with early RA with progression in bone erosions (n = 14) compared to early RA patients without progression (n = 30; first year 8.4 vs 2.8 ng/l, p = 0.04; second year 6.1 vs 3.6 ng/l, p = 0.03). CONCLUSION:Plasma IL-6 was the only biomarker related to treatment response and progressive erosive disease in patients with early RA, but it may not give additional information compared to CRP in relation to disease activity and treatment response. 相似文献
100.
Gabriela Senti Bettina M. Prinz Vavricka Iris Erdmann Mella I. Diaz Richard Markus Stephen J. McCormack John J. Simard Brunello Wüthrich Reto Crameri Nicole Graf P?l Johansen Thomas M. Kündig 《Proceedings of the National Academy of Sciences of the United States of America》2008,105(46):17908-17912
The only causative treatment for IgE-mediated allergies is allergen-specific immunotherapy. However, fewer than 5% of allergy patients receive immunotherapy because of its long duration and risk of allergic side effects. We aimed at enhancing s.c. immunotherapy by direct administration of allergen into s.c. lymph nodes. The objective was to evaluate safety and efficacy compared with conventional s.c. immunotherapy. In a monocentric open-label trial, 165 patients with grass pollen-induced rhinoconjunctivitis were randomized to receive either 54 s.c. injections with pollen extract over 3 years [cumulative allergen dose 4,031,540 standardized quality units (SQ-U)] or 3 intralymphatic injections over 2 months (cumulative allergen dose 3,000 SQ-U). Patients were evaluated after 4 months, 1 year, and 3 years by nasal provocation, skin prick testing, IgE measurements, and symptom scores. Three low-dose intralymphatic allergen administrations increased tolerance to nasal provocation with pollen already within 4 months (P < 0.001). Tolerance was long lasting and equivalent to that achievable after standard s.c. immunotherapy (P = 0.291 after 3 years). Intralymphatic immunotherapy ameliorated hay fever symptoms (P < 0.001), reduced skin prick test reactivity (P < 0.001), decreased specific serum IgE (P < 0.001), caused fewer adverse events than s.c. immunotherapy (P = 0.001), enhanced compliance (P < 0.001), and was less painful than venous puncture (P = 0.018). In conclusion, intralymphatic allergen administration enhanced safety and efficacy of immunotherapy and reduced treatment time from 3 years to 8 weeks. 相似文献