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Jorge Csar Correia Hafsa Meraj Soo Huat Teoh Ahmed Waqas Maaz Ahmad Luis Velez Lapo Zoltan Pataky Alain Golay 《Bulletin of the World Health Organization》2021,99(3):209
ObjectiveTo determine the effectiveness of telemedicine in the delivery of diabetes care in low- and middle-income countries.MethodsWe searched seven databases up to July 2020 for randomized controlled trials investigating the effectiveness of telemedicine in the delivery of diabetes care in low- and middle-income countries. We extracted data on the study characteristics, primary end-points and effect sizes of outcomes. Using random effects analyses, we ran a series of meta-analyses for both biochemical outcomes and related patient properties.FindingsWe included 31 interventions in our meta-analysis. We observed significant standardized mean differences of −0.38 for glycated haemoglobin (95% confidence interval, CI: −0.52 to −0.23; I2 = 86.70%), −0.20 for fasting blood sugar (95% CI: −0.32 to −0.08; I2 = 64.28%), 0.81 for adherence to treatment (95% CI: 0.19 to 1.42; I2 = 93.75%), 0.55 for diabetes knowledge (95% CI: −0.10 to 1.20; I2 = 92.65%) and 1.68 for self-efficacy (95% CI: 1.06 to 2.30; I2 = 97.15%). We observed no significant treatment effects for other outcomes, with standardized mean differences of −0.04 for body mass index (95% CI: −0.13 to 0.05; I2 = 35.94%), −0.06 for total cholesterol (95% CI: −0.16 to 0.04; I2 = 59.93%) and −0.02 for triglycerides (95% CI: −0.12 to 0.09; I2 = 0%). Interventions via telephone and short message service yielded the highest treatment effects compared with services based on telemetry and smartphone applications.ConclusionAlthough we determined that telemedicine is effective in improving several diabetes-related outcomes, the certainty of evidence was very low due to substantial heterogeneity and risk of bias. 相似文献
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Ilda Patrícia Ribeiro Francisco Marques Francisco Caramelo José Ferrão Hugo Prazeres Maria José Julião Widad Rifi Suvi Savola Joana Barbosa de Melo Isabel Poiares Baptista Isabel Marques Carreira 《Tumour biology》2014,35(5):4687-4695
Oral tumors are a growing health problem worldwide; thus, it is mandatory to establish genetic markers in order to improve diagnosis and early detection of tumors, control relapses and, ultimately, delineate individualized therapies. This study was the first to evaluate and discuss the clinical applicability of a multiplex ligation-dependent probe amplification (MLPA) probe panel directed to head and neck cancer. Thirty primary oral squamous cell tumors were analyzed using the P428 MLPA probe panel. We detected genetic imbalances in 26 patients and observed a consistent pattern of distribution of genetic alterations in terms of losses and gains for some chromosomes, particularly for chromosomes 3, 8, and 11. Regarding the latter, some specific genes were highlighted due to frequent losses of genetic material—RARB, FHIT, CSMD1, GATA4, and MTUS1—and others due to gains—MCCC1, MYC, WISP1, PTK2, CCND1, FGF4, FADD, and CTTN. We also verified that the gains of MYC and WISP1 genes seem to suggest higher propensity of tumors localized in the floor of the mouth. This study proved the value of this MLPA probe panel for a first-tier analysis of oral tumors. The probemix was developed to include target regions that have been already shown to be of diagnostic/prognostic relevance for oral tumors. Furthermore, this study emphasized several of those specific genetic targets, suggesting its importance to oral tumor development, to predict patients’ outcomes, and also to guide the development of novel molecular therapies. 相似文献
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Mariana P. Marmorato Núria Pedreño‐Lopez Joana R. Deheinzelin Diogo M. Magnani Varian K. Bailey Priscilla R. Costa Luiz G.F.A.B.D. Zanella Carlos H.V. Moreira Renata Buccheri Vivian I. Avelino‐Silva Natália B. Cerqueira Cássia G.T. Silveira Ho Yeh‐Li David I. Watkins Esper G. Kallás 《The Brazilian journal of infectious diseases》2018
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Gas separation using porous solids have attracted great attention due to their energetic applications. There is an enormous economic and environmental interest in the development of improved technologies for relevant processes, such as H2 production, CO2 separation or O2 and N2 purification from air. New materials are needed for achieving major improvements. Crystalline materials, displaying unidirectional and single-sized pores, preferentially with low pore tortuosity and high pore density, are promising candidates for membrane synthesis. Herein, we study hexagonal ice crystals as an example of this class of materials. By slowly growing ice crystals inside capillary tubes we were able to measure the permeation of several gas species through ice crystals and investigate its relation with both the size of the guest molecules and temperature of the crystal. 相似文献
70.
Andre R. Dur?es Milena A. O. Dur?es Luis C. L. Correia Roque Aras 《Arquivos brasileiros de cardiologia》2013,101(5):466-471
Heart valve prosthesis unquestionably improve quality of life and survival of
patients with severe valvular heart disease, but the need for antithrombotic therapy
to prevent thromboembolic complications is a major challenge to clinicians and their
patients. Of the articles analyzed, most were retrospective series of cases or
historical cohorts obtained from the database. The few published randomized trials
showed no statistical power to assess the primary outcome of death or thromboembolic
event. In this article, we decided to perform a systematic literature review, in an
attempt to answer the following question: what is the best antithrombotic strategy in
the first three months after bioprosthetic heart valve implantation (mitral and
aortic)?After two reviewers applying the extraction criteria, we found 1968 references,
selecting 31 references (excluding papers truncated, which combined bioprosthesis
with mechanical prosthesis, or without follow-up).Based on this literature review, there was a low level of evidence for any
antithrombotic therapeutic strategy evaluated. It´s therefore interesting to use
aspirin 75 to 100 mg / day as antithrombotic strategy after bioprosthesis replacement
in the aortic position, regardless of etiology, for patients without other risk
factors such as atrial fibrillation or previous thromboembolic event. In the mitral
position, the risk of embolism, although low, is more relevant than in the aortic
position, according to published series and retrospective cohorts comprised mostly of
elderly non-rheumatic patients.The current evidence is limited to have a consistent and safe level of evidence
regarding the best therapeutic strategy. Based on these studies, 75 to 100 mg/day of
aspirin is interesting as antithrombotic strategy after implantation of aortic
bioprosthesis, regardless of etiology, for patients with no other risk factors such
as atrial fibrillation or previous thromboembolic event. As for mitral bioprosthesis,
the risk of embolism, although low, is more relevant than in the aortic position,
according to published series and retrospective cohorts - usually elderly non
rheumatic patients. 相似文献