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971.
Alice Song Edson Abdala Daniel Waisberg Rodrigo Bronze Martino Ho Yeh Li Luiz Marcelo Sa Malbouisson Ryan Yukimatsu Tanigawa Amaro Duarte Neto Guilherme Marques Andrade Liliana Ducatti Andre Mario Doi João Renato Rebello Pinho Michele Gomes‐Gouvea Fernanda Malta Lecio Figueira Pinto Bruno Fukelmann Guedes Luciana Haddad Venancio Avancini F. Alves Luiz Augusto D. Albuquerque 《The Brazilian journal of infectious diseases》2018
972.
Priccila Zuchinali Gabriela C. Souza Graziella Aliti Mariana R. Botton Lívia Goldraich Katia G. Santos Mara H. Hutz Eliane Bandinelli Luis E. Rohde 《Journal of thrombosis and thrombolysis》2014,37(3):338-344
Significant inter-individual variability on the effect of vitamin K to reverse overanticoagulation has been identified. Genetic polymorphisms of the vitamin K epoxide reductase complex subunit 1 (VKORC1) gene might explain in part this variability. The objective of this study was to evaluate the influence of VKORC1 ?1639G>A and 3730G>A polymorphisms on the effect of oral vitamin K supplementation in overanticoagulated patients. We performed an interventional trial of oral vitamin K supplementation in over-anticoagulated outpatients (international normalized ratio [INR] ≥ 4). Subjects received vitamin K (2.5–5.0 mg) according to baseline INR and were genotyped by real time polymerase chain reaction (PCR). INR values were determined at 3, 6, 24 and 72 h after supplementation. We evaluated 33 outpatients, 61 % were males, with a mean age of 62 ± 12 years old. There was a significant decrease in INR values over time for both polymorphisms after oral vitamin K. At 3 h after supplementation, patients carrying the G allele for the ?1639G>A polymorphism had a greater decrease in INR values compared to AA patients (p < 0.05 for difference among groups; p < 0.001 for time variation; p = 0.001 for time × group interaction), with differences of ?1.01 for GG versus AA (p = 0.003) and ?0.84 for GA versus AA (p = 0.024). Mean INR value at 24 h was 1.9 ± 0.6 and at 72 h was 2.1 ± 0.7, with no differences among genotypes. No significant interaction was identified between the 3730G>A polymorphism and vitamin K supplementation. Our study indicated that the VKORC1 ?1639G>A polymorphism plays a role in the response to acute vitamin K supplementation in over-anticoagulated patients, with faster decrease of INR value in patients carrying the G allele. 相似文献
973.
Ventricular arrhythmias (VA) are a significant contributor to morbidity and mortality in patients with heart failure (HF). Implantable cardioverter defibrillators are effective in reducing mortality, but do not prevent arrhythmia recurrence. There is increasing recognition that frequent premature ventricular contractions or repetitive ventricular tachycardia may also lead to new onset ventricular dysfunction or deterioration of ventricular function in patients with pre-existing HF. Suppression of the arrhythmia may lead to recovery of ventricular function. Catheter ablation has emerged as a safe and effective treatment option for reducing arrhythmia recurrence and for suppression of PVCs but its efficacy is governed by the nature of the arrhythmias, the underlying HF substrate and the accessibility of the arrhythmia substrates to ablation. 相似文献
974.
975.
Cultural adaptation and analysis of the psychometric properties of the Brazilian version of the Spiritual Distress Scale 下载免费PDF全文
976.
977.
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979.
Edilberto A Rocha Filho José C Lima Jo?o S Pinho Neto Ulisses Montarroyos 《Reproductive health》2011,8(1):2
Objective
To evaluate the effectiveness and safety of polyunsaturated fatty acids for the treatment of the premenstrual syndrome (PMS) using a graded symptom scale and to assess the effect of this treatment on basal plasma levels of prolactin and total cholesterol. 相似文献980.
Renata da Silva Pereira Etiane Tatsch Guilherme Vargas Bochi Helena Kober Thiago Duarte Greice Franciele Feyh dos Santos Montagner José Edson Paz da Silva Marta Maria Medeiros Frescura Duarte Ivana Beatrice Mânica da Cruz Rafael Noal Moresco 《Inflammation》2013,36(4):869-877
The aim of this study was to assess the levels of oxidative, inflammatory, and fibrinolytic biomarkers as well as DNA strand breakage in hypercholesterolemic subjects. Fasting glucose, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, uric acid, total protein, albumin, apolipoprotein (Apo) A, Apo B, advanced oxidation protein products (AOPP), increased ischemia-modified albumin (IMA), ―SH, NOx, IL-6, and D-dimer levels were assessed, and DNA strand breakage was evaluated using comet assay in 38 patients with hypercholesterolemia and 20 healthy controls. Total cholesterol, triglycerides, LDL cholesterol, Apo A, Apo B, AOPP, IMA, IL-6, and D-dimer concentrations were significantly higher in subjects with hypercholesterolemia. However, NOx and plasma ―SH group concentrations were lower in hypercholesterolemic subjects, while no significant differences were observed with respect to DNA strand breakage between the two groups. Hypercholesterolemia is related to oxidative stress and inflammation. Accordingly, AOPP concentration was higher in subjects with hypercholesterolemia, and we speculate that AOPP can reflect the enhancement of protein oxidation and inflammation. 相似文献