全文获取类型
收费全文 | 14214篇 |
免费 | 975篇 |
国内免费 | 231篇 |
专业分类
耳鼻咽喉 | 306篇 |
儿科学 | 160篇 |
妇产科学 | 173篇 |
基础医学 | 2352篇 |
口腔科学 | 209篇 |
临床医学 | 1053篇 |
内科学 | 2832篇 |
皮肤病学 | 673篇 |
神经病学 | 1150篇 |
特种医学 | 995篇 |
外科学 | 1871篇 |
综合类 | 49篇 |
一般理论 | 2篇 |
预防医学 | 473篇 |
眼科学 | 396篇 |
药学 | 1166篇 |
中国医学 | 188篇 |
肿瘤学 | 1372篇 |
出版年
2024年 | 11篇 |
2023年 | 126篇 |
2022年 | 392篇 |
2021年 | 554篇 |
2020年 | 328篇 |
2019年 | 450篇 |
2018年 | 496篇 |
2017年 | 408篇 |
2016年 | 623篇 |
2015年 | 869篇 |
2014年 | 984篇 |
2013年 | 1066篇 |
2012年 | 1497篇 |
2011年 | 1359篇 |
2010年 | 906篇 |
2009年 | 708篇 |
2008年 | 794篇 |
2007年 | 780篇 |
2006年 | 685篇 |
2005年 | 628篇 |
2004年 | 449篇 |
2003年 | 380篇 |
2002年 | 352篇 |
2001年 | 96篇 |
2000年 | 62篇 |
1999年 | 59篇 |
1998年 | 49篇 |
1997年 | 39篇 |
1996年 | 23篇 |
1995年 | 26篇 |
1994年 | 14篇 |
1993年 | 13篇 |
1992年 | 20篇 |
1991年 | 19篇 |
1990年 | 16篇 |
1989年 | 13篇 |
1988年 | 12篇 |
1987年 | 15篇 |
1986年 | 8篇 |
1985年 | 6篇 |
1984年 | 13篇 |
1983年 | 7篇 |
1982年 | 8篇 |
1981年 | 10篇 |
1980年 | 6篇 |
1979年 | 4篇 |
1978年 | 7篇 |
1973年 | 5篇 |
1968年 | 3篇 |
1967年 | 5篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
Matt G Kushner Suck Won Kim Christopher Donahue Paul Thuras David Adson Michael Kotlyar James McCabe Jillian Peterson Edna B Foa 《Neuropsychopharmacology》2007,62(8):835-838
BACKGROUND: D-cycloserine (DCS), a glutamatergic partial N-methyl-d-aspartate (NMDA) agonist, can facilitate extinction learning related to cued fear in animals and humans. We predicted that DCS would accelerate obsession-related distress reduction in patients with obsessive-compulsive disorder (OCD) undergoing extinction-based exposure therapy. METHODS: We administered DCS (125 mg) or placebo in a double-blind fashion to individuals with OCD approximately 2 hours before each exposure session. RESULTS: D-cycloserine decreased both the number of exposure sessions required to achieve clinical milestones and the rate of therapy dropout. After four exposure sessions, patients in the DCS group reported significantly greater decreases in obsession-related distress compared with the placebo group; however, after additional sessions, the placebo group tended to catch up. CONCLUSIONS: D-cycloserine augmentation has the potential to increase the efficiency, palatability, and overall effectiveness of standard exposure therapy for OCD. 相似文献
32.
Howard L Kaufman Seunghee Kim-Schulze Kelledy Manson Gail DeRaffele Josephine Mitcham Kang Seok Seo Dae Won Kim John Marshall 《Journal of translational medicine》2007,5(1):60
Purpose
An open-label Phase 1 study of recombinant prime-boost poxviruses targeting CEA and MUC-1 in patients with advanced pancreatic cancer was conducted to determine safety, tolerability and obtain preliminary data on immune response and survival. 相似文献33.
S H Jee S Y Won J E Yun J E Lee J S Park S S Ji 《International journal of gynaecology and obstetrics》2004,85(3):301-308
OBJECTIVES: Although some studies have reported that the arginine isoform on codon 72 of p53 increases the susceptibility to invasive cervical cancer, such data remain controversial. The objective of this study was to quantitatively summarize the evidence for such a relationship. METHODS: Our data sources consisted of a MEDLINE search of the literature published before December 2002, bibliography review, and expert consultation. Thirty-seven studies met the inclusion criteria. Information on sample size, study design, Hardy-Weinberg equilibrium, and method of genotype determination was abstracted by two reviewers using a standardized protocol. The overall odds ratio (OR) of the p53 gene on invasive cervical cancer was estimated using the Mantel-Haenzel method. RESULTS: The overall OR (95% confidence interval) for cervical cancer among those with the homozygous mutant (Arg/Arg) was 1.2 (1.1-1.3, P=0.001) compared with those with the heterozygous mutant (Arg/Pro). By a cellular type of cervical cancer, the overall OR among those with Arg/Arg was statistically significant in adenocarcinomas (1.7, 1.1-2.6, P=0.024), but not in squamous cell carcinomas (1.1, 0.9-1.2, P=0.960), compared with Pro/Pro. Compared with Arg/Pro, the OR among those with Arg/Arg was statistically significant in HPV types 16 (1,5, 1.2-2.0, P=0.002). CONCLUSIONS: Overall, the p53 gene was associated with increased risk for invasive cervical cancer. However, the risk varied by country, cellular, and HPV type. 相似文献
34.
Jae Sue Choi Han Suk Young Jong Cheol Park Jin-Ho Choi Won Sick Woo 《Archives of pharmacal research》1986,9(4):233-236
The flavonoids isolated from the leaves ofRhododendron brachycarpum, were identified as quercetin, avicularin, quercitrin and hyperin. 相似文献
35.
The hexane extract from Nutmeg, the seed ofMyristica fragrans significantly inhibited hepatic drug-metabolizing enzyme activity. Through systematic fractionation by SiO2 column and vacuum liquid chromatography monitoring by bioassay, three components, myristicin, (I), licarin-B(II) and dehydrodiisoeugenol(III) were isolated as active principles. Compounds II and III, with a single treatment (200 mg/kg, i.p.) showed not only a significant prolongation of hexobarbital-induced sleeping time but also a significant inhibition of aminopyrine N-demethylase and hexobarbital hydroxylase activities in mice. Compounds I and II provoked a sleep episode at a subhypnotic dose of HB, suggesting that they posses CNS-depressant properties. 相似文献
36.
Yang Hee Lee Ihn Rhan Lee Won Sick Won Chung Hee Park 《Archives of pharmacal research》1988,11(3):247-249
37.
Summary 1. The effects of microinjection of 5-hydroxytryptamine (5-HT) or its antagonists methysergide (a 5-HT1 receptor antagonist), cyproheptadine (a mixed 5-HT1/5-HT2 receptor antagonist), or ketanserin (a 5-HT2 receptor antagonist) into the preoptic anterior hypothalamus on thermoregulatory responses were assessed in conscious rabbits at different ambient temperatures (T
a). 2. Intrahypothalamic injection of 5-HT caused dose-dependent hypothermia in rabbits when the T
a was 2°C and 22°C. At 2°C the hypothermia was due to decreased metabolism, whereas at 22°C the hypothermia was due to increased peripheral blood flow and increased respiratory evaporative heat loss. 3. In contrast, administration of either cyproheptadine, methysergide or ketanserin into the 5-HT-sensitive sites in the preoptic anterior hypothalamus caused dose-dependent hyperthermia in rabbits when the T
a was 2°C, 22°C and 32°C. At 2°C the hyperthermia was due to increased metabolism, whereas at 32°C the hyperthermia was due to decreased peripheral blood flow and decreased respiratory evaporative heat loss. At 22°C, the hyperthermia was due to increased metabolism and decreased peripheral blood flow. 4. For a given intrahypothalamic dose (e.g.15–20 g), either methysergide, cyproheptadine or ketanserin produced the same degree of rectal temperature elevation (e.g. about 1.4°C) in rabbits. Thus, there did not appear to be any association between hypothalamic 5-HT receptor types and thermoregulation. 5. However, the present results suggest that hypothalamic 5-HT receptors mediate thermoregulatory responses in the rabbit. Activation of hypothalamic 5-HT receptors decreases heat production and increases heat loss, whereas inhibition of hypothalamic 5-HT receptors increases heat production and decreases heat loss in the rabbit.This study was supported by grants from the National Science Council of the Republic of China.
Send offprint requests to S. J. Won at the above address 相似文献
38.
Overexpression of S100A4 is closely related to the aggressiveness of gastric cancer 总被引:25,自引:0,他引:25
Cho YG Nam SW Kim TY Kim YS Kim CJ Park JY Lee JH Kim HS Lee JW Park CH Song YH Lee SH Yoo NJ Lee JY Park WS 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2003,111(5):539-545
Elevated levels of the calcium-binding protein S100A4 cause metastasis of benign rat mammary tumor cells. To investigate whether S100A4 plays an important role in the invasion and metastasis of gastric cancers, we examined the gene mutations in the coding regions and expression patterns of the S100A4 in gastric adenocarcinoma in Korea. Moderate to strong expression of S100A4 was found in 53 (68.8%) of the 77 gastric adenocarcinomas, whilst normal gastric epithelium either failed to stain or showed weak staining. Interestingly, S100A4 expression was more frequently observed in gastric cancer patients with advanced gastric cancer (p=0.039), positive lymph node metastasis (p=0.001), and peritoneal dissemination (p=0.022). No gene mutations were found in the analyzed genomic area in 77 gastric adenocarcinomas and 15 gastric cancer cell lines. We found one single nucleotide polymorphism without an amino acid change, A99G, in two cases. These data suggest that the overexpression of S100A4 may be closely related to the aggressiveness of gastric cancer in Korea. 相似文献
39.
Flora Hoodin Leah LaLonde Josh Errickson Kristen Votruba Rachel Kentor Erin Gatza Pavan Reddy Sung Won Choi 《Biology of blood and marrow transplantation》2019,25(2):343-353
Myeloablative conditioning allogeneic hematopoietic cell transplantation (HCT) puts patients at greater risk for significant cognitive and quality of life decline compared with recipients of reduced-intensity conditioning or autologous HCT. Vorinostat, a histone deacetylase inhibitor, has been shown to have neuroprotective and neurorestorative effects in preclinical models of neurologic diseases. Thus, within the context of a myeloablative conditioning phase II clinical trial of vorinostat combined with tacrolimus and methotrexate for graft-versus-host disease prophylaxis, we conducted an ancillary study to evaluate feasibility of assessing associations between vorinostat and neurocognitive function and quality of life (ClinicalTrials.gov NCT02409134). Nine patients (mean age, 53 years; range, 36 to 66) underwent computerized neuropsychological testing (Cogstate) and completed surveys of mood (Patient Health Questionnaire-9), anxiety (General Anxiety Disorder-7), and quality of life (Functional Assessment of Cancer Therapy–General). Control cohorts from a separate concurrent longitudinal study (19 autologous and 18 allogeneic HCT patients, who matched the vorinostat patients on relevant medical and demographic variables) completed the same test battery. All allogeneic patients received busulfan-based myeloablative conditioning and were transplanted with HLA-matched unrelated donors. The total neurocognitive performance score of vorinostat patients did not change significantly across the study duration (ie, baseline, day 30, day 100, and day 160). Depression, anxiety, and quality of life also did not differ significantly across time. In univariate analyses (analysis of variance), vorinostat-treated patients showed no difference in neurocognitive function or quality of life compared with autologous and allogeneic control subjects. However, when medical variables were accounted for in a linear mixed effects regression model, the total neurocognitive performance of vorinostat-treated patients was comparable with autologous control subjects. Notably, autologous control subjects performed significantly better than allogeneic control subjects (estimate, .64; standard error, .23; P ≤ .01). Moreover, a smaller percentage of vorinostat-treated patients were classified as mildly, moderately, or severely impaired across neurocognitive domains as well as time points compared with both control cohorts. Thus, vorinostat may have neurorestorative or neuroprotective effects in the HCT setting. Accordingly, we recognize the need for a future, full-scale randomized controlled trial to further examine this hypothesis. 相似文献
40.
Seo JS Lee SY Won KJ Kim DJ Sohn DS Yang KM Cho SH Park JD Lee KH Kim HD 《Journal of Korean medical science》2000,15(6):641-646
We provided a curve-fit equation to predict the normal heart weight (g) in Koreans by examining 422 autopsies (215 males and 207 females, from newborn to age 77 yr) who were relatively in good general condition. Heart weight was well correlated with body surface area (m2), body weight (kg), and body height (cm) but poorly with age in both sex. Heart weight progressively increased from birth to the earlier 3rd and 4th decades in male and female, respectively, and then gradually decreased; mean heart weight of all age group was greater in male than in female and significantly different from birth to 4th decade. In both sex, heart weight exponentially increased in accordance with the increase of body height, body weight, and body surface (in male, heart weight=0.00312 x body height(2.239), r2=0.750, p<0.0001; in female, heart weight=0.00443 x body height(2170), r2=0.781, p<0.0001; in male, heart weight=9.22 x body weight(0.853), r2=0.770, p<0.0001; in female, heart weight=9.00 x body weight0.855, r2=0.820, p<0.0001; in male, heart weight=155.18 x body surface area1.290, r=0.808, p<0.0001; in female, heart weight=124.13 x body surface area1.242, r=0.834, p<0.0001). These results indicate that heart weight is better correlated with body surface area than with body weight; however, body weight should be a better determinant of a predicted heart weight, since body surface area is entirely dependent on body height and body weight. 相似文献