全文获取类型
收费全文 | 206664篇 |
免费 | 56103篇 |
国内免费 | 8714篇 |
专业分类
耳鼻咽喉 | 3052篇 |
儿科学 | 5827篇 |
妇产科学 | 1934篇 |
基础医学 | 29920篇 |
口腔科学 | 7527篇 |
临床医学 | 28169篇 |
内科学 | 39974篇 |
皮肤病学 | 9164篇 |
神经病学 | 18722篇 |
特种医学 | 8201篇 |
外国民族医学 | 45篇 |
外科学 | 26374篇 |
综合类 | 25744篇 |
现状与发展 | 43篇 |
一般理论 | 31篇 |
预防医学 | 14251篇 |
眼科学 | 4830篇 |
药学 | 20921篇 |
161篇 | |
中国医学 | 9449篇 |
肿瘤学 | 17142篇 |
出版年
2024年 | 410篇 |
2023年 | 1891篇 |
2022年 | 4579篇 |
2021年 | 8009篇 |
2020年 | 9924篇 |
2019年 | 14392篇 |
2018年 | 14062篇 |
2017年 | 15335篇 |
2016年 | 15844篇 |
2015年 | 18060篇 |
2014年 | 19445篇 |
2013年 | 19984篇 |
2012年 | 15628篇 |
2011年 | 16136篇 |
2010年 | 17389篇 |
2009年 | 12585篇 |
2008年 | 10636篇 |
2007年 | 9168篇 |
2006年 | 8552篇 |
2005年 | 7195篇 |
2004年 | 5727篇 |
2003年 | 5477篇 |
2002年 | 4829篇 |
2001年 | 3671篇 |
2000年 | 2960篇 |
1999年 | 2058篇 |
1998年 | 1136篇 |
1997年 | 1037篇 |
1996年 | 840篇 |
1995年 | 750篇 |
1994年 | 712篇 |
1993年 | 453篇 |
1992年 | 479篇 |
1991年 | 423篇 |
1990年 | 377篇 |
1989年 | 323篇 |
1988年 | 220篇 |
1987年 | 215篇 |
1986年 | 168篇 |
1985年 | 109篇 |
1984年 | 69篇 |
1983年 | 47篇 |
1982年 | 39篇 |
1981年 | 31篇 |
1980年 | 29篇 |
1979年 | 18篇 |
1978年 | 7篇 |
1975年 | 7篇 |
1973年 | 12篇 |
1972年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
111.
112.
113.
114.
医科大学医学生健康教育培训需求度和满意度现状分析 《医学教育管理》2019,5(1):60
目的 了解医学生学习《健康教育》课程的满意度、需求度现状及差异,为《健康教育》课程优化提供参考。方法 以某医科大学在校临床医学生为研究对象,分析医学生对课程内容的需求度和满意度及二者差异。课程内容包括服药依从性、戒烟干预、合理膳食、心理压力管理、中医康复技术、慢性传染病健康教育、急性传染病健康教育、移动健康技术教育、运动康复指导及健康促进理论。采用频数和构成比指标进行统计描述,采用卡方检验进行健康教育课程学习情况与专业/ 学制之间、相关课程内容学习的需求度与学制的差异,相关课程内容学习需求度与满意度的关联比较采用秩和检验。以P < 0.05 为差异具有统计学意义。结果 戒烟干预、合理膳食、心理压力管理、中医康复技术、慢性传染病健康教育、急性传染病健康教育、移动健康技术教育及健康促进理论八项的学习需求度在长学制医学生与五年制医学生中的总体分布位置不同(U = 2.4、2.2、2.5、2.3、2.4、2.4、2.3、2.0,P 均< 0.05);服药依从性、戒烟干预、合理膳食、心理压力管理、慢性传染病健康教育、急性传染病健康教育、移动健康技术教育及运动康复指导八项的满意度与需求度之间的总体位置分布不同(U = 6.2、5.2、7.2、9.2、5.9、6.1、2.1、3.2,P 均< 0.05);不同学制的医学生对于慢性病人、老年人、孕产妇、传染病人、高危人群和职业暴露人群的健康教育重点关注人群侧重有所不同,其差异具有统计学意义(χ2 = 8.9、14.2、9.9、6.9、23.9、17.8,P 均< 0.05);在教学方式上,不同学制的医学生对于教师课堂讲授和小组讨论的偏好上的差异具有统计学意义(χ2=6.3、9.5,P 均< 0.05)。结论 当前健康教育课程的教学内容和结构未能完全满足不同学制、年级医学生的学习需求,需要对课程教学内容、教学方式和开设时间进行进一步的优化设计。 相似文献
115.
Tuberculosis (TB) remains one of a major health problem worldwide. Tuberculosis vaccine research has made an extraordinary progress over the past few years. However, there is still no replacement for the Bacillus Calmette‐Guérin vaccine, the only TB vaccine licensed for human use. Therefore, the discovery and development of new TB vaccines remains a priority. This article discusses current strategies used to diversify TB vaccines and includes discussion of the status of efforts to improve protection against Mycobacterium tuberculosis (M tb) infection or TB disease by developing new and safe TB vaccines. This article also highlights the current research efforts in immune‐enhancing approaches to improve vaccination efficacy. The development of more effective TB vaccines might have significant impact on global TB control. 相似文献
116.
117.
Erika Cecon Anna Ivanova Marine Luka Florence Gbahou Anne Friederich Jean‐Luc Guillaume Patrick Keller Klaus Knoch Raise Ahmad Philippe Delagrange Michele Solimena Ralf Jockers 《Journal of pineal research》2019,66(2)
Melatonin receptors play important roles in the regulation of circadian and seasonal rhythms, sleep, retinal functions, the immune system, depression, and type 2 diabetes development. Melatonin receptors are approved drug targets for insomnia, non‐24‐hour sleep‐wake disorders, and major depressive disorders. In mammals, two melatonin receptors (MTRs) exist, MT1 and MT2, belonging to the G protein‐coupled receptor (GPCR) superfamily. Similar to most other GPCRs, reliable antibodies recognizing melatonin receptors proved to be difficult to obtain. Here, we describe the development of the first monoclonal antibodies (mABs) for mouse MT1 and MT2. Purified antibodies were extensively characterized for specific reactivity with mouse, rat, and human MT1 and MT2 by Western blot, immunoprecipitation, immunofluorescence, and proximity ligation assay. Several mABs were specific for either mouse MT1 or MT2. None of the mABs cross‐reacted with rat MTRs, and some were able to react with human MTRs. The specificity of the selected mABs was validated by immunofluorescence microscopy in three established locations (retina, suprachiasmatic nuclei, pituitary gland) for MTR expression in mice using MTR‐KO mice as control. MT2 expression was not detected in mouse insulinoma MIN6 cells or pancreatic beta‐cells. Collectively, we report the first monoclonal antibodies recognizing recombinant and native mouse melatonin receptors that will be valuable tools for future studies. 相似文献
118.
Xiaojie Wu Leyan Zhang Jiadi Zhou Luying Liu Qiang Fu Aili Fu Xiaoying Feng Rui Xin Hongrui Liu Yong Gao Jiangnan Xue 《Current problems in cancer》2019,43(1):18-26
Aim
Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is an immune inhibitory receptor which is expressed within most types of hematopoietic cells and negatively regulates immune responses. Recently, we found LAIR-1 expression to be present within tumors of nonhematopoietic lineages. However, the roles of LAIR-1 in hepatocellular carcinoma (HCC) have yet to be examined. The purpose of this study was to investigate the expression of LAIR-1 in HCC tissue and assess its clinical significance at this site.Materials and methods
Expression levels of LAIR-1 within HCC samples collected from 90 patients and compared with that of slides of normal liver tissue collected from 9 non-HCC patients were measured by immunohistochemistry using tissue microarrays. A semiquantitative score was assigned, as was based on staining intensity and percent of positive cells and a Spearman Rank correlation test was used to assess any potential significant correlations between LAIR-1 expression and clinicopathological factors. Overall survival analysis was performed using the Kaplan-Meier and Log Rank statistical test.Results
LAIR-1 expression was detected in cancer tissue and adjacent tumor tissue, but not in normal liver tissue. The percent of LAIR-1-positive expression in cancer tissue of HCC samples was 97.78% (88/90) while that in adjacent tumor tissue was 96.67% (87/90). Significantly greater expression levels of LAIR-1 were obtained from cancer tissue (Mean?±?SD?=?5.722?±?2.145) than that in adjacent tumor tissue (4.141?±?1.486). In addition, LAIR-1 expression was found to be significantly correlated with pathological grade of HCC, T stage, and age. Expression levels of LAIR-1 were related with worse overall survival rates of HCC patients, especially in HCC patients with hepatic cirrhosis.Conclusion
Results of this study show that LAIR-1 is expressed in HCC tissues and that high levels of LAIR-1 expression are associated with the poor cancer differentiation. In addition, overexpression of LAIR-1 was significantly associated with worse overall survival in the patients with HCC. These data suggest that LAIR-1 may be an independent predictor for clinical outcomes in patients with HCC. 相似文献119.
120.