全文获取类型
收费全文 | 1644篇 |
免费 | 144篇 |
国内免费 | 112篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 13篇 |
妇产科学 | 17篇 |
基础医学 | 149篇 |
口腔科学 | 34篇 |
临床医学 | 328篇 |
内科学 | 193篇 |
皮肤病学 | 14篇 |
神经病学 | 76篇 |
特种医学 | 57篇 |
外国民族医学 | 1篇 |
外科学 | 151篇 |
综合类 | 321篇 |
一般理论 | 1篇 |
预防医学 | 88篇 |
眼科学 | 23篇 |
药学 | 190篇 |
1篇 | |
中国医学 | 100篇 |
肿瘤学 | 137篇 |
出版年
2024年 | 2篇 |
2023年 | 28篇 |
2022年 | 66篇 |
2021年 | 87篇 |
2020年 | 84篇 |
2019年 | 43篇 |
2018年 | 66篇 |
2017年 | 53篇 |
2016年 | 45篇 |
2015年 | 75篇 |
2014年 | 90篇 |
2013年 | 77篇 |
2012年 | 156篇 |
2011年 | 139篇 |
2010年 | 98篇 |
2009年 | 84篇 |
2008年 | 116篇 |
2007年 | 122篇 |
2006年 | 78篇 |
2005年 | 82篇 |
2004年 | 57篇 |
2003年 | 44篇 |
2002年 | 26篇 |
2001年 | 26篇 |
2000年 | 25篇 |
1999年 | 27篇 |
1998年 | 16篇 |
1997年 | 22篇 |
1996年 | 15篇 |
1995年 | 8篇 |
1994年 | 8篇 |
1993年 | 3篇 |
1992年 | 6篇 |
1991年 | 5篇 |
1990年 | 3篇 |
1989年 | 4篇 |
1988年 | 2篇 |
1987年 | 3篇 |
1986年 | 4篇 |
1984年 | 1篇 |
1981年 | 1篇 |
1974年 | 1篇 |
1969年 | 2篇 |
排序方式: 共有1900条查询结果,搜索用时 15 毫秒
41.
[目的]了解25%氯硝柳胺悬浮剂(SCN)在丘陵山区果园内灭螺效果,并进行成本-效果评价。[方法]选择宜兴市山丘地区2处有螺果园为试验现场,采用灭螺机喷洒的方法,实验组用SCN按2.0g/m2、对照组用50%氯硝柳胺乙醇胺盐可湿性粉剂(WPN)按4.0g/m2喷洒灭螺,比较两组有螺面积下降率和活螺密度下降率;以有螺面积下降率和活螺密度下降率作为评价指标进行成本-效果分析。[结果]实验组用SCN喷洒4次,灭螺后30d有螺面积下降率和活螺密度下降率均为100.0%,有螺面积和活螺密度每下降1个百分点的费用均为56.00元,分别优于对照组WPN的99.00%、92.25%和92.93元、99.73元。[结论]用SCN山区灭螺,操作方便,成本低,灭螺效果好,具有良好应用前景。 相似文献
42.
不同浓度四氯化碳复合法诱导家兔肝纤维化模型的建立 总被引:4,自引:1,他引:3
目的 寻找到适宜做影像学和血清学研究的动物家兔肝纤维化模型建市方法.方法 分别用体积比为5%四氯化碳(CCl4)油溶液和纯CCl4,按0.1 ml/kg剂量每周1次腹腔注射,并辅以5%浓度的乙醇作为饮水,诱导家兔肝纤维化形成,并于注射后6、8、10、12周分组处夕匕家兔取其肝脏进行病理学检查.结果 家兔的死亡多发生在4周之内,6周之后趋于稳定.5%CCl4浓度组家兔死亡率为60%,纯CCl4组死亡率为25%.结论 长期给予CCl4可导致家兔的肝纤维化形成,采用腹腔注射纯CCI4,同时辅以5%浓度的乙醇作为饮水的复合法造模,家兔死亡率低,成模率高. 相似文献
43.
44.
45.
Jin-Ming Cen Jie Cheng Qing-Yuan Xiong Bai-Qiang Mei Wei-Biao Cai Xi-Li Yang 《慢性疾病与转化医学(英文)》2015,1(2):105-109
ObjectiveThis study explores the correlation between plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) and coronary heart disease (CHD) by comparing the level of plasma Lp-PLA2 in the plasma of patients with different types of CHD.MethodsBlood samples were collected from 56 patients diagnosed with CHD by the Department of Cardiology of the First People''s Hospital of Foshan and 34 healthy subjects from February 2013 to January 2014. We measured the concentration of plasma Lp-PLA2 and determined the levels of total cholesterol (Tch), triglyceride (TG), apolipoprotein A1 (Apo-A1), apolipoprotein B (Apo-B), high density lipoprotein-cholesterol (HDL-c), low density lipoprotein-cholesterol (LDL-c), lipoprotein a (Lp(a)), glucose (Glu), and high-sensitivity C-reactive protein (hs-CRP). The concentration of plasma Lp-PLA2 in the healthy control group and each subgroup of CHD patients were compared and analyzed for correlations of plasma Lp-PLA2 between the patients in different CHD subgroups and several laboratory indicators.ResultsThe concentration of plasma Lp-PLA2 in each subgroup of CHD was significantly higher than in the control group (P < 0.05). The concentration of Lp-PLA2 in the unstable angina pectoris (UAP) group and acute myocardial infarction (AMI) group were significantly higher than in the stable angina pectoris (SAP) group (P < 0.05), and the concentration of plasma Lp-PLA2 in the AMI group was significantly higher than in the UAP group (P < 0.05). The concentration of plasma Lp-PLA2 in the CHD group merely showed a positive correlation (r = 0.493, P < 0.05) with the hs-CRP group, but the levels of Tch, TG, Apo-A1, Apo-B, HDL-c, LDL-c, Lp(a) and Glu did not.ConclusionsThe concentration of plasma Lp-PLA2 in patients with CHD was higher than that in the control group. The concentration of plasma Lp-PLA2 in the subgroups of CHD patients varied greatly from each other. The inflammatory response of atherosclerosis might be resulted from the synergy of plasma Lp-PLA2 and hs-CRP. 相似文献
46.
Cen Xiang Yuou Teng Chaoran Yao Xuehui Li Menglin Cao Xuzhe Li Guojun Pan Kui Lu Herv Galons Peng Yu 《RSC advances》2018,8(28):15366
Excessive accumulation of free radicals in the body can cause liver damage, aging, cancer, stroke, and myocardial infarction. Anastatin B, a skeletal flavonoid, was reported to have antioxidant and hepatoprotective effects. Anastatin B derivatives, compound 1 and 2, were synthesized by our group previously. In this study, their antioxidant activity and hepatoprotective mechanism were studied using chemical evaluation methods, a cellular model of hydrogen peroxide (H2O2)-induced oxidative damage, and a mouse model of carbon tetrachloride (CCl4)-induced liver injury. Results from the chemical evaluation suggested that both compounds had good antioxidant power and radical scavenging ability in vitro. MTT assay showed that both compounds had cytoprotective activity in H2O2-treated PC12 cells. Moreover, their hepatoprotective activities evaluated using a mouse model of CCl4-induced liver injury that compared with the model group, pretreatment with compound 1 and 2 significantly decreased alanine transaminase (ALT), aspartate transaminase (AST), lactate dehydrogenase (LDH), and malondialdehyde (MDA) levels; reduced the liver tissue damage; and increased glutathione content. However, compound 2 was a more effective hepatoprotectant than compound 1 was. Finally, the amount of TNF-α and cytochrome P450 2E1 (CYP2E1) were significantly downregulated in compound 1 and 2 pretreatment groups. Collectively, our findings demonstrate that both compounds have potential antioxidant activity and hepatoprotective effect in vitro and in vivo. Further chemo-biological study and investigation of the compounds'' enzymatic targets are ongoing.Excessive accumulation of free radicals in the body can cause liver damage, aging, cancer, stroke, and myocardial infarction. 相似文献
47.
Biological CO2 elimination by photosynthetic microalgae is a sustainable way to mitigate CO2 from flue gas and other sources. Computational fluid dynamics was used to simulate algal cell movement with an enhanced flashing light effect in a novel panel bioreactor with horizontal baffles. Calculation results showed that the light/dark (L/D) cycle period decreased by 17.5% from 17.1 s to 14.1 s and that the horizontal fluid velocity increased by 95% while horizontal baffles were used under a 0.02 vvm air aeration rate and a microalgal concentration of 0.85 g L−1. The probability of the L/D cycle period within 5–10 s increased from 27.9% to 43.6%, indicating a 56% increase when horizontal baffles existed. It was proved by experiments that the mass-transfer coefficient increased by 31% and the mixing time decreased by 13% under a 0.06 vvm air aeration rate when horizontal baffles were used, and the algal biomass yield increased by ∼51% along with the decrease in the L/D cycle period when horizontal baffles were used.Biological CO2 elimination by photosynthetic microalgae is a sustainable way to mitigate CO2 from flue gas and other sources. 相似文献
48.
This work aims to provide a comprehensive understanding of negative DC discharge under coal pyrolysis gas components (CO2, H2, N2, CH4, CO) and air. The characteristics of negative DC discharge were studied in a wire–cylinder configuration at an ambient temperature range of 20–600 °C by analyzing V–I characteristics, discharge photographs, and gas composition. With increasing temperature, corona onset voltage, spark breakdown voltage and operational voltage range for corona discharge decrease, but discharge current and electron current ratio increase. Discharge current of CO2 is higher than that of air due to the difference of electronegativity. During CO2 discharge, with the increase of output voltage, three types of discharge are successively observed, namely corona, glow and arc. However, during H2 discharge, only glow discharge is observed. Temperatures significantly affect the capability of CO to attach electrons. The discharge characteristic of CO is similar to the electronegative gas media at 20 °C and the non-electronegative gas media when the temperature exceeds 350 °C. Chemical reactions and carbon generation are observed during the CH4 and CO discharge process. The product of carbon filaments under the CH4 gas medium leads to discharge current volatility and short circuit. These results assist in understanding the property of ESP at high temperatures.This work aims to provide a comprehensive understanding of negative DC discharge under coal pyrolysis gas components (CO2, H2, N2, CH4, CO) and air. 相似文献
49.
50.
小肝癌的数字减影血管造影、计算机X线体层扫描和磁共振成像诊断进展 总被引:11,自引:0,他引:11
原发性肝癌是世界上常见的恶性肿瘤,其发病率高,预后差,因此肝癌的早期发现和诊断对于临床治疗效果有极其重要的作用,是提高肝癌术后生存率的关键。由于大部分血供丰富的病灶由肝动脉供血,因此理想的数字减影血管造影(digitalSubtraction angiography,DSA)、CT和MRI动态增强扫描均能反映其血供特点,随着影像技术的不断发展,小肝癌(直径≤3cm)的病灶检出率已经明显提高。本文将重点介绍小肝癌DSA、CT、MRI的诊断进展及影像学表现。 相似文献