全文获取类型
收费全文 | 17170篇 |
免费 | 1429篇 |
国内免费 | 41篇 |
专业分类
耳鼻咽喉 | 164篇 |
儿科学 | 574篇 |
妇产科学 | 473篇 |
基础医学 | 2379篇 |
口腔科学 | 185篇 |
临床医学 | 1982篇 |
内科学 | 3392篇 |
皮肤病学 | 258篇 |
神经病学 | 1998篇 |
特种医学 | 331篇 |
外科学 | 1772篇 |
综合类 | 99篇 |
一般理论 | 18篇 |
预防医学 | 2453篇 |
眼科学 | 231篇 |
药学 | 1035篇 |
中国医学 | 9篇 |
肿瘤学 | 1287篇 |
出版年
2024年 | 23篇 |
2023年 | 307篇 |
2022年 | 478篇 |
2021年 | 1164篇 |
2020年 | 696篇 |
2019年 | 966篇 |
2018年 | 1030篇 |
2017年 | 683篇 |
2016年 | 700篇 |
2015年 | 758篇 |
2014年 | 970篇 |
2013年 | 1193篇 |
2012年 | 1738篇 |
2011年 | 1696篇 |
2010年 | 784篇 |
2009年 | 650篇 |
2008年 | 1048篇 |
2007年 | 899篇 |
2006年 | 776篇 |
2005年 | 601篇 |
2004年 | 480篇 |
2003年 | 404篇 |
2002年 | 326篇 |
2001年 | 33篇 |
2000年 | 26篇 |
1999年 | 30篇 |
1998年 | 44篇 |
1997年 | 27篇 |
1996年 | 9篇 |
1995年 | 15篇 |
1994年 | 11篇 |
1993年 | 7篇 |
1992年 | 7篇 |
1991年 | 5篇 |
1990年 | 3篇 |
1989年 | 5篇 |
1988年 | 4篇 |
1985年 | 4篇 |
1984年 | 5篇 |
1983年 | 2篇 |
1982年 | 4篇 |
1980年 | 4篇 |
1979年 | 4篇 |
1977年 | 2篇 |
1975年 | 2篇 |
1973年 | 3篇 |
1971年 | 2篇 |
1964年 | 3篇 |
1959年 | 1篇 |
1933年 | 1篇 |
排序方式: 共有10000条查询结果,搜索用时 312 毫秒
991.
992.
993.
994.
Claire Edwards MD Stephanie Williams BS Anita P. McSwain MD MPH Sameer Damle MD Jocelyn A. Rapelyea MD Kara Downs BA Jessica Torrente MD Anita Sambamurty BS Rachel F Brem MD Christine B. Teal MD 《The breast journal》2013,19(5):512-519
Breast‐specific gamma imaging (BSGI) is a physiologic breast imaging modality that provides more sensitive detection of breast lesions than mammography or ultrasound, and appears to have greater specificity than breast MRI. The purpose of this study was to evaluate how often BSGI changed surgical management in patients with breast cancer. Charts were reviewed from 218 consecutive eligible patients who had preoperative evaluation with BSGI or MRI before surgery for breast cancer from January 2008 to May 2010. Patients who were initially considered eligible for breast‐conserving therapy (BCT) were evaluated to determine how many ultimately had mastectomies. Patients who underwent mastectomy because of personal choice or ineligibility for BCT were excluded. Management was changed to mastectomy in 11.9% of those who had BSGI and 28.9% of those who had MRI. Review of pathology demonstrated that all patients who underwent mastectomies were not candidates for breast conservation. 15.4% of patients who underwent BCT based on BSGI findings required a single re‐excision due to positive surgical margins. 14.4% required mastectomy. In the MRI group, 18.8% required a single re‐excision, and 6.3% required mastectomy. Evaluation with BSGI changed management to mastectomy in a substantial proportion of patients believed to be eligible for BCT following standard imaging. BSGI is effective in evaluation of extent of disease in patients with breast cancer, and is comparable to MRI in terms of its influence on surgical management. 相似文献
995.
996.
997.
998.
Jon B. Toledo Matthias Arnold Gabi Kastenmüller Rui Chang Rebecca A. Baillie Xianlin Han Madhav Thambisetty Jessica D. Tenenbaum Karsten Suhre J. Will Thompson Lisa St. John-Williams Siamak MahmoudianDehkordi Daniel M. Rotroff John R. Jack Alison Motsinger-Reif Shannon L. Risacher Colette Blach Joseph E. Lucas Rima Kaddurah-Daouk 《Alzheimer's & dementia》2017,13(9):965-984
Introduction
The Alzheimer's Disease Research Summits of 2012 and 2015 incorporated experts from academia, industry, and nonprofit organizations to develop new research directions to transform our understanding of Alzheimer's disease (AD) and propel the development of critically needed therapies. In response to their recommendations, big data at multiple levels are being generated and integrated to study network failures in disease. We used metabolomics as a global biochemical approach to identify peripheral metabolic changes in AD patients and correlate them to cerebrospinal fluid pathology markers, imaging features, and cognitive performance.Methods
Fasting serum samples from the Alzheimer's Disease Neuroimaging Initiative (199 control, 356 mild cognitive impairment, and 175 AD participants) were analyzed using the AbsoluteIDQ-p180 kit. Performance was validated in blinded replicates, and values were medication adjusted.Results
Multivariable-adjusted analyses showed that sphingomyelins and ether-containing phosphatidylcholines were altered in preclinical biomarker-defined AD stages, whereas acylcarnitines and several amines, including the branched-chain amino acid valine and α-aminoadipic acid, changed in symptomatic stages. Several of the analytes showed consistent associations in the Rotterdam, Erasmus Rucphen Family, and Indiana Memory and Aging Studies. Partial correlation networks constructed for Aβ1–42, tau, imaging, and cognitive changes provided initial biochemical insights for disease-related processes. Coexpression networks interconnected key metabolic effectors of disease.Discussion
Metabolomics identified key disease-related metabolic changes and disease-progression-related changes. Defining metabolic changes during AD disease trajectory and its relationship to clinical phenotypes provides a powerful roadmap for drug and biomarker discovery. 相似文献999.
Peter Kochunov L. Elliot Hong Emily L. Dennis Rajendra A. Morey David F. Tate Elisabeth A. Wilde Mark Logue Sinead Kelly Gary Donohoe Pauline Favre Josselin Houenou Christopher R. K. Ching Laurena Holleran Ole A. Andreassen Laura S. van Velzen Lianne Schmaal Julio E. Villaln-Reina Carrie E. Bearden Fabrizio Piras Gianfranco Spalletta Odile A. van den Heuvel Dick J. Veltman Dan J. Stein Meghann C. Ryan Yunlong Tan Theo G. M. van Erp Jessica A. Turner Liz Haddad Talia M. Nir David C. Glahn Paul M. Thompson Neda Jahanshad 《Human brain mapping》2022,43(1):194-206
The ENIGMA-DTI (diffusion tensor imaging) workgroup supports analyses that examine the effects of psychiatric, neurological, and developmental disorders on the white matter pathways of the human brain, as well as the effects of normal variation and its genetic associations. The seven ENIGMA disorder-oriented working groups used the ENIGMA-DTI workflow to derive patterns of deficits using coherent and coordinated analyses that model the disease effects across cohorts worldwide. This yielded the largest studies detailing patterns of white matter deficits in schizophrenia spectrum disorder (SSD), bipolar disorder (BD), major depressive disorder (MDD), obsessive–compulsive disorder (OCD), posttraumatic stress disorder (PTSD), traumatic brain injury (TBI), and 22q11 deletion syndrome. These deficit patterns are informative of the underlying neurobiology and reproducible in independent cohorts. We reviewed these findings, demonstrated their reproducibility in independent cohorts, and compared the deficit patterns across illnesses. We discussed translating ENIGMA-defined deficit patterns on the level of individual subjects using a metric called the regional vulnerability index (RVI), a correlation of an individual's brain metrics with the expected pattern for a disorder. We discussed the similarity in white matter deficit patterns among SSD, BD, MDD, and OCD and provided a rationale for using this index in cross-diagnostic neuropsychiatric research. We also discussed the difference in deficit patterns between idiopathic schizophrenia and 22q11 deletion syndrome, which is used as a developmental and genetic model of schizophrenia. Together, these findings highlight the importance of collaborative large-scale research to provide robust and reproducible effects that offer insights into individual vulnerability and cross-diagnosis features. 相似文献
1000.
Large‐scale brain network abnormalities in Huntington's disease revealed by structural covariance
下载免费PDF全文
![点击此处可从《Human brain mapping》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Lora Minkova Simon B. Eickhoff Ahmed Abdulkadir Christoph P. Kaller Jessica Peter Elisa Scheller Jacob Lahr Raymund A. Roos Alexandra Durr Blair R. Leavitt Sarah J. Tabrizi Stefan Klöppel TRACK‐HD Investigators 《Human brain mapping》2016,37(1):67-80
Huntington's disease (HD) is a progressive neurodegenerative disorder that can be diagnosed with certainty decades before symptom onset. Studies using structural MRI have identified grey matter (GM) loss predominantly in the striatum, but also involving various cortical areas. So far, voxel‐based morphometric studies have examined each brain region in isolation and are thus unable to assess the changes in the interrelation of brain regions. Here, we examined the structural covariance in GM volumes in pre‐specified motor, working memory, cognitive flexibility, and social‐affective networks in 99 patients with manifest HD (mHD), 106 presymptomatic gene mutation carriers (pre‐HD), and 108 healthy controls (HC). After correction for global differences in brain volume, we found that increased GM volume in one region was associated with increased GM volume in another. When statistically comparing the groups, no differences between HC and pre‐HD were observed, but increased positive correlations were evident for mHD, relative to pre‐HD and HC. These findings could be explained by a HD‐related neuronal loss heterogeneously affecting the examined network at the pre‐HD stage, which starts to dominate structural covariance globally at the manifest stage. Follow‐up analyses identified structural connections between frontoparietal motor regions to be linearly modified by disease burden score (DBS). Moderator effects of disease load burden became significant at a DBS level typically associated with the onset of unequivocal HD motor signs. Together with existing findings from functional connectivity analyses, our data indicates a critical role of these frontoparietal regions for the onset of HD motor signs. Hum Brain Mapp 37:67–80, 2016. © 2015 Wiley Periodicals, Inc. 相似文献