全文获取类型
收费全文 | 5270篇 |
免费 | 269篇 |
国内免费 | 108篇 |
专业分类
耳鼻咽喉 | 94篇 |
儿科学 | 61篇 |
妇产科学 | 48篇 |
基础医学 | 879篇 |
口腔科学 | 116篇 |
临床医学 | 538篇 |
内科学 | 1010篇 |
皮肤病学 | 112篇 |
神经病学 | 458篇 |
特种医学 | 374篇 |
外科学 | 721篇 |
综合类 | 30篇 |
预防医学 | 212篇 |
眼科学 | 55篇 |
药学 | 462篇 |
1篇 | |
中国医学 | 76篇 |
肿瘤学 | 400篇 |
出版年
2024年 | 1篇 |
2023年 | 45篇 |
2022年 | 167篇 |
2021年 | 240篇 |
2020年 | 108篇 |
2019年 | 122篇 |
2018年 | 154篇 |
2017年 | 123篇 |
2016年 | 196篇 |
2015年 | 344篇 |
2014年 | 351篇 |
2013年 | 391篇 |
2012年 | 563篇 |
2011年 | 540篇 |
2010年 | 275篇 |
2009年 | 244篇 |
2008年 | 329篇 |
2007年 | 307篇 |
2006年 | 240篇 |
2005年 | 164篇 |
2004年 | 115篇 |
2003年 | 100篇 |
2002年 | 89篇 |
2001年 | 78篇 |
2000年 | 70篇 |
1999年 | 42篇 |
1998年 | 46篇 |
1997年 | 20篇 |
1996年 | 22篇 |
1995年 | 21篇 |
1994年 | 22篇 |
1993年 | 22篇 |
1992年 | 15篇 |
1991年 | 7篇 |
1990年 | 1篇 |
1989年 | 7篇 |
1988年 | 15篇 |
1987年 | 12篇 |
1986年 | 11篇 |
1985年 | 3篇 |
1984年 | 4篇 |
1983年 | 7篇 |
1982年 | 3篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1975年 | 3篇 |
排序方式: 共有5647条查询结果,搜索用时 0 毫秒
991.
J.P. Jeon Y.D. Cho D.H. Yoo J. Moon J. Lee W.-S. Cho H.-S. Kang J.E. Kim M.H. Han 《AJNR. American journal of neuroradiology》2017,38(9):1765
BACKGROUND AND PURPOSE:Long-term documentation of anatomic and angiographic characteristics pertaining to the timing of recanalization in coiled aneurysms has been insufficient. Our intent was to analyze and compare early and late-phase recanalization after coiling, identifying respective risk factors.MATERIALS AND METHODS:A total of 870 coiled saccular aneurysms were monitored for extended periods (mean, 30.8 ± 8.3 months). Medical records and radiologic data were also reviewed, stratifying patients as either early (n = 128) or late (n = 52) recanalization or as complete occlusion (n = 690). Early recanalization was equated with confirmed recanalization within 6 months after the procedure, whereas late recanalization was defined as verifiable recanalization after imaging confirmation of complete occlusion at 6 months. A multinomial regression model served to assess potential risk factors, the reference point being early recanalization.RESULTS:Posterior circulation (P = .009), subarachnoid hemorrhage at presentation (P = .011), second attempt for recanalized aneurysm (P < .001), and aneurysm size >7 mm (P < .001) emerged as variables significantly linked with early recanalization (versus complete occlusion). Late (versus early) recanalization corresponded with aneurysms ≤7 mm (P = .013), and in a separate subanalysis of lesions ≤7 mm, aneurysms 4–7 mm showed a significant predilection for late recanalization (P = .008). However, the propensity for complete occlusion in smaller lesions (≤7 mm) increased as the size diminished.CONCLUSIONS:Although long-term complete occlusion after coiling was more likely in aneurysms ≤7 mm, such lesions were more prone to late (versus early) recanalization, particularly those of 4–7 mm in size. Long-term follow-up imaging is thus appropriate in aneurysms >4 mm to detect late recanalization of those formerly demonstrating complete occlusion.Endovascular coiling is widely used in treating intracranial aneurysms. Despite continued improvement in related techniques and devices, the potential for recanalization remains. Risk factors linked to recanalization have been studied widely through comparative analysis, examining SAH at presentation, larger aneurysms, posterior locations, and other variables.1,2 Coiled aneurysms showing major recanalization are subsequently in need of additional coiling, given the odds of rebleeding. Raymond et al3 found that 46.9% of all recanalizations occurred within 6 months of procedures, with nearly 40% showing major recanalization.4 As a function of the follow-up duration, aneurysm size and neck diameter and initial postembolization status were associated with the recanalization of coiled aneurysms monitored for 17 months.3 However, in coiled aneurysms followed for <17 months, the initial postembolization status emerged as the sole significant risk factor for recanalization. Such a discrepancy may imply that risk factors inherent in aneurysm configuration have a greater long-term impact on recanalization.4,5 Therefore, an association between the timing of recanalization and related risk factors is feasible. Most previous studies in this setting have limited risk factor analysis to patients showing either recanalization or complete occlusion, without considering time to recanalization. In this study, coiled saccular aneurysms were monitored over a longer term to analyze and compare early and late-phase recanalization, thereby identifying respective risk factors. 相似文献
992.
993.
Jun-Hyung Cho Seong Ran Jeon Hyun Gun Kim So-Young Jin Suyeon Park 《Scandinavian journal of gastroenterology》2017,52(12):1320-1325
Objective: This study aimed to evaluate the optimal biopsy site for Helicobacter pylori detection by comparing the results of rapid urease test (RUT) between the gastric corpus and the antrum.Methods: A biopsy specimen from each subject was obtained from the corpus and from the antrum. For each subject, the two specimens were separately immersed in two different RUT kits. Positive reaction times were measured at 20?minutes and 1, 3, and 24?hours. If either of the two RUT kits showed a positive reaction, H. pylori infection was confirmed.Results: A total of 310 H. pylori-infected subjects were eligible for study inclusion. Compared with the antrum, positive RUT reaction times in the corpus were shorter when the degree of gastric atrophy was moderate or severe (p?=?.001 and p?.001, respectively). A multivariate analysis revealed that the factors resulting in a faster positive RUT reaction in the corpus were age ≥50 years (odds ratio [OR]?=?1.84; 95% confidence interval [CI]?=?1.10–3.08; p?=?.021) and severe gastric atrophy (OR?=?2.41; 95% CI?=?1.13–5.13; p?=?.023). Also, severe gastric atrophy was an independent factor associated with positive RUT reaction only in the corpus (OR?=?5.12; 95% CI?=?1.55–16.88; p?=?.007).Conclusions: In subjects aged ≥50 years or with severe gastric atrophy, biopsy of the corpus mucosa optimized the efficiency of H. pylori detection through a faster positive RUT reaction. 相似文献
994.
Lee Hyun Seok Lim Yun Jeong Shim Ki Nam Moon Chang Mo Song Hyun Joo Kim Jin Oh Jeon Seong Ran Jung Dae Young Kim Ji Hyun Kim Kyeong Ok Lee Bo-In 《Digestive diseases and sciences》2017,62(1):180-187
Digestive Diseases and Sciences - Capsule endoscopy (CE) has proven to be highly effective at detecting small bowel lesions, but studies regarding the diagnostic impact of CE on ileitis are rare.... 相似文献
995.
Topical cannabinoid receptor 1 agonist attenuates the cutaneous inflammatory responses in oxazolone‐induced atopic dermatitis model 下载免费PDF全文
996.
Dieckol,a phlorotannin of Ecklonia cava,suppresses IgE‐mediated mast cell activation and passive cutaneous anaphylactic reaction 下载免费PDF全文
997.
Poikiloderma vasculare atrophicans (PVA) is a rare poikilodermatous variant of early-stage mycosis fungoides characterized by generalized poikiloderma, atrophy, mottled dyspigmentation, and telangiectasia. In 2001, a 14-year-old male presented with asymptomatic brownish-gray polymorphic macules throughout the body with flexural accentuation. A skin biopsy showed increased melanophages with focal hydropic changes. Ashy dermatosis was considered a possible diagnosis. In 2005, the lesions began to show darkening and lichenification in the lower part of the trunk. In 2011, his skin showed definite poikilodermatous changes, and a biopsy showed band-like inflammatory infiltrations of atypical lymphocytes, epidermal atrophy, and epidermotropism of predominantly CD4-CD8+ atypical T cells. In addition, results of T-cell receptor gene rearrangement analysis were positive. Based on the aforementioned findings, he was diagnosed with PVA. If a patient shows long-standing and progressive hyperpigmentary skin changes, periodic follow-up and repeated skin biopsies are recommended to determine the underlying condition. 相似文献
998.
Yao-Kuang Wang Fu-Chen Kuo Chung-Jung Liu Meng-Chieh Wu Hsiang-Yao Shih Sophie SW Wang Jeng-Yih Wu Chao-Hung Kuo Yao-Kang Huang Deng-Chyang Wu 《World journal of gastroenterology : WJG》2015,21(40):11221-11235
Accurate diagnosis of Helicobacter pylori (H. pylori) infection is a crucial part in the effective management of many gastroduodenal diseases. Several invasive and non-invasive diagnostic tests are available for the detection of H. pylori and each test has its usefulness and limitations in different clinical situations. Although none can be considered as a single gold standard in clinical practice, several techniques have been developed to give the more reliable results. Invasive tests are performed via endoscopic biopsy specimens and these tests include histology, culture, rapid urease test as well as molecular methods. Developments of endoscopic equipment also contribute to the real-time diagnosis of H. pylori during endoscopy. Urea breathing test and stool antigen test are most widely used non-invasive tests, whereas serology is useful in screening and epidemiological studies. Molecular methods have been used in variable specimens other than gastric mucosa. More than detection of H. pylori infection, several tests are introduced into the evaluation of virulence factors and antibiotic sensitivity of H. pylori, as well as screening precancerous lesions and gastric cancer. The aim of this article is to review the current options and novel developments of diagnostic tests and their applications in different clinical conditions or for specific purposes. 相似文献
999.
Hyun Jeong Lee Gwang Ha Kim Do Youn Park Bong Eun Lee Hye Kyung Jeon Joon Hyung Jhi Geun Am Song 《World journal of gastroenterology : WJG》2015,21(13):3944-3952
AIM: To identify the clinicopathological predictors of lymph node(LN) metastasis and evaluate the outcomes of endoscopic submucosal dissection(ESD) in papillary adenocarcinoma-type early gastric cancers(EGCs).METHODS: From January 2005 to May 2013, 49 patients who underwent surgical operation and 24 patients who underwent ESD for papillary adenocarcinomatype EGC were enrolled to identify clinicopathological characteristics and predictive factors of LN metastasis and to evaluate the outcomes of ESD for papillary adenocarcinoma-type EGC.RESULTS: Most papillary adenocarcinoma-type EGCs were located in the lower third of the stomach and had an elevated macroscopic shape. The overall prevalence of LN metastasis was 18.3%(9/49). The presence of lymphovascular invasion was found to be a predictor of LN metastasis(P = 0.016). According to current indication criteria of ESD, 6 and 11 of the 49 patients had absolute and expanded indications for ESD, respectively. Two patients(11.8%) with expanded indication for ESD had LN metastasis. Of the 24 patients who underwent ESD, 13(54%) achieved out-of-ESD indication, with 9 of those 13 patients undergoing surgical operation due to non-curative resection. CONCLUSION: The use of ESD should be carefully considered for papillary adenocarcinoma-type EGC with suspected ESD indication after pre-treatment work-up because of the higher frequency of LN metastasis and additional surgeries. 相似文献
1000.
Jun-Young Kim Se-Mi Jeon Hyungjun Kim Mi-Sun Park Seong-Han Kim 《Osong Public Health and Research Perspectives》2011,2(3):216-217
In this study, we measured the drug resistance conferred by mdfA mutations in two Shigella flexneri strains. A mutant in mdfA genes was constructed by polymerase chain reaction–based, one-step inactivation of chromosomal genes. The antimicrobial susceptibility of parent and mutant strains to fluoroquinolones was determined by minimal inhibitory concentration (MICs). The △mdfA mutants were somewhat more susceptible to fluoroquinolones than the parent strains. The low level changes in MICs of the △mdfA mutants suggest that mdfA contributed the fluoroquinolone resistance in S flexneri. This finding found that the increased expression level of an MdfA efflux pump mediated fluoroquinolone resistance, but it is not likely a major effecter of higher resistance levels. 相似文献