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71.
72.
Objective. To determine the stability of an admixture combining ziconotide with bupivacaine hydrochloride during simulated intrathecal infusion under laboratory conditions at 37°. Materials and Methods. An admixture containing ziconotide (25 µg/mL) and bupivacaine hydrochloride (5 mg/mL) was stored in SynchroMed® II pumps at 37° and in control vials at either 37° or 5°. Using high‐performance liquid chromatography, drug concentrations were determined from samples obtained at varying intervals during the 30‐day study. Results. After 30 days, pump ziconotide and bupivacaine hydrochloride concentrations measured an average of 86.9% and 99.4% of their initial concentrations, respectively. Control vials displayed similar degradation rates for both drugs. Statistical evaluation of the ziconotide 95% confidence interval indicated that the ziconotide concentration would meet or exceed 90% and 80% of initial concentration for 22 days and 45 days, respectively. Conclusions. An admixture containing 25 µg/mL ziconotide and 5 mg/mL bupivacaine hydrochloride was 90% stable for 22 days and 80% stable for 45 days (extrapolated) in SynchroMed® II infusion pumps. 相似文献
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N. M. van Schoor D. L. Knol C. A. W. Glas R. W. J. G. Ostelo A. Leplège C. Cooper O. Johnell P. Lips 《Osteoporosis international》2006,17(4):543-551
Introduction Vertebral deformities are a common consequence of osteoporosis and are known to decrease quality of life. The Qualeffo–41
is a quality-of-life questionnaire especially developed for measuring quality of life in patients with vertebral deformities.
It consists of 41 questions arranged in five domains: pain, physical function, social function, general health perception,
and mental function. The objectives of this study were: (1) to develop a shorter version of the Qualeffo–41 by removing redundant
questions; and (2) to investigate the scale characteristics, reliability, and validity of this shorter version.
Methods The study was performed using data from the Qualeffo validation study and the Multiple Outcomes of Raloxifene Evaluation (MORE)
study. The analyses were performed in patients with vertebral deformities (n=579). Factor analysis on polychoric correlations and an item response theory (IRT) model, i.e., the generalized partial credit
model (GPCM), were used to create a shorter version of Qualeffo–41. Using GPCM, scoring weights were computed for all items.
Results Three items were removed from the data set because of too many missing values. Factor analysis identified three instead of
five domains: (1) pain, (2) physical function, and (3) mental function. Five items had factor loadings <0.4 and were not included
in the GPCM. After excluding several items, the domains pain (four items), physical function (18 items), and mental function
(nine items) showed a good, reasonable, and excellent fit, respectively. This indicates that the mental function domain and
the pain domain are more unidimensional than the physical function domain. All three domains showed a very high correlation
(r ≥0.95) with the corresponding domains of the Qualeffo–41.
Conclusions Qualeffo–31 was developed, consisting of three domains with a reasonable to excellent fit to the GPCM. Although the fit to
the GPCM supports the construct validity of the Qualeffo–31, validation in a new study should be performed before using it
in practice. 相似文献
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R A Cooper 《Journal of rehabilitation research and development》1992,29(3):29-34
The purpose of this study was to determine the relationship between selected anthropometric and physiological variables and 10K time. Eleven male wheelchair athletes with spinal cord injuries in training for national competition performed continuous progressive exercise tests on a wheelchair ergometer to determine maximal metabolic and cardiorespiratory values. Anthropometric data were also collected. The laboratory data were analyzed for correlation with the best 10K time of each subject during the test period. The subjects averaged 27 min 30 sec for their 10K races, 2.49 L.min-1 for VO2max and 35 percent for maximal gross mechanical efficiency during submaximal exercise. Speed at peak oxygen consumption (r = -0.66), gross mechanical efficiency (r = -0.56), and body density (r = -0.57) was found to be significantly (p less than 0.10) correlated with 10K time. The results show very little correlation between VO2max and 10K time (r = 0.02). Further study is indicated for the relationship between gross mechanical efficiency, speed at maximal oxygen consumption, body density, and 10K time; these variables may be useful in evaluating training programs for improving race performance. 相似文献
78.
Use of a new videolaryngoscope (GlideScope®) in the management of a difficult airway 总被引:13,自引:0,他引:13
Richard M. Cooper 《Journal canadien d'anesthésie》2003,50(6):611-613
PURPOSE: To describe the clinical use of a new videolaryngoscope in a patient who had repeatedly been difficult or impossible to intubate by conventional direct laryngoscopy. This device provided excellent glottic visualization and permitted easy endotracheal intubation. CLINICAL FEATURES: A 74-yr-old male presenting for repeat elective surgery had a history of failed intubations by direct laryngoscopy and pulmonary aspiration with a laryngeal mask airway. He refused awake flexible fibreoptic intubation. After the induction of general anesthesia, laryngoscopy was performed using a GlideScope. This provided complete glottic exposure and easy endotracheal intubation. CONCLUSION: This new videolaryngoscope provided excellent laryngeal exposure in a patient whom multiple experienced anesthesiologists had repeatedly found to be difficult or impossible to intubate using direct laryngoscopy. The clinical role of this device awaits confirmation in a large series of difficult airways. 相似文献
79.
Religious orientation, aging, and blood pressure reactivity to interpersonal and cognitive stressors
Kevin S. Masters Ph.D. Robert D. Hill Ph.D. John C. Kircher Ph.D. Tera L. Lensegrav Benson M.S. Jennifer A. Fallon M.S. 《Annals of behavioral medicine》2004,28(3):171-178
Background: Research on religion and health suggests general health benefits for those who are more religiously involved. Particular
aspects of religiosity that may influence this finding, however, have not been sufficiently investigated.Purpose: This study was designed to explore the relationship between religious orientation (intrinsic, extrinsic) and blood pressure
reactivity among older (over 60 years) and younger (18–24 years) adults exposed to two qualitatively different laboratory
stressors (cognitive, interpersonal).Methods:Participants were categorized as exhibiting either a predominately intrinsic or extrinsic religious orientation based on scores
on the Religious Orientation Scale. They were subsequently exposed (in counterbalanced order) to two laboratory stressors
that varied in terms of whether an interpersonal confrontation was involved. Measures of blood pressure were obtained at baseline
and during stressor presentation.Results: Analyses indicated that older extrinsically religious individuals demonstrated exaggerated reactivity compared to younger
participants and older intrinsically religious individuals. Older intrinsically religious participants did not differ from
younger persons. Similar results were found for analysis of baseline data. Extrinsic participants had greater reactivity during
the interpersonal confrontation condition than did intrinsic individuals.Conclusions: These findings suggest that religious orientation may be an important variable to study regarding cardiovascular reactivity
in, particularly, older adults.
This research was supported in part by National Institute on Aging Grant 1 R03 AG 18554-01. A previous version of this article
was presented in August 2002 as a Citation Paper at the 110th Annual Convention of the American Psychological Association,
Chicago.
We thank Timothy W. Smith, James A. Blumenthal, Carl E. Thoresen, and Edward M. Heath for their assistance throughout this
project. We also thank Llewellyn Jones and Jodi Hildabrandt for their efforts in collecting data. 相似文献
80.
Brief chemotherapy, involved field radiation therapy, and central nervous system prophylaxis for paranasal sinus lymphoma. 总被引:1,自引:0,他引:1
Lymphoma of the paranasal sinus is a rare tumor characterized by bulky local disease, early systemic dissemination, and a propensity for central nervous system (CNS) spread. Treatment with radiation alone generally has been disappointing. Based on previous encouraging reports of initial brief chemotherapy followed by involved field radiation therapy (IFRT) for localized large cell lymphoma, four consecutive patients with paranasal sinus lymphoma were treated with 6 weeks of chemotherapy followed by IFRT and CNS prophylaxis. All patients had bulky localized disease and diffuse large cell lymphoma. Complete response was seen in all patients, and none have had a relapse (minimum follow-up, 25 months; range, 25 to 32 months). Chemotherapy and radiation therapy were well tolerated. One patient developed an osteogenic sarcoma in the radiation field 32 months after completion of therapy. Administration of early frequent chemotherapy followed by IFRT and CNS prophylaxis appears to be an effective treatment strategy for patients with localized large cell lymphoma of the paranasal sinuses. 相似文献