全文获取类型
收费全文 | 1062篇 |
免费 | 79篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 40篇 |
妇产科学 | 84篇 |
基础医学 | 140篇 |
口腔科学 | 12篇 |
临床医学 | 152篇 |
内科学 | 181篇 |
皮肤病学 | 23篇 |
神经病学 | 105篇 |
特种医学 | 36篇 |
外科学 | 99篇 |
综合类 | 9篇 |
一般理论 | 5篇 |
预防医学 | 95篇 |
眼科学 | 3篇 |
药学 | 89篇 |
中国医学 | 2篇 |
肿瘤学 | 59篇 |
出版年
2023年 | 8篇 |
2022年 | 12篇 |
2021年 | 24篇 |
2020年 | 16篇 |
2019年 | 20篇 |
2018年 | 25篇 |
2017年 | 22篇 |
2016年 | 20篇 |
2015年 | 21篇 |
2014年 | 39篇 |
2013年 | 42篇 |
2012年 | 67篇 |
2011年 | 69篇 |
2010年 | 41篇 |
2009年 | 43篇 |
2008年 | 68篇 |
2007年 | 82篇 |
2006年 | 51篇 |
2005年 | 47篇 |
2004年 | 37篇 |
2003年 | 41篇 |
2002年 | 30篇 |
2001年 | 8篇 |
2000年 | 22篇 |
1999年 | 18篇 |
1998年 | 15篇 |
1997年 | 13篇 |
1995年 | 5篇 |
1993年 | 5篇 |
1992年 | 15篇 |
1991年 | 12篇 |
1990年 | 20篇 |
1989年 | 7篇 |
1988年 | 8篇 |
1987年 | 12篇 |
1986年 | 11篇 |
1985年 | 12篇 |
1984年 | 5篇 |
1983年 | 12篇 |
1981年 | 7篇 |
1979年 | 5篇 |
1978年 | 7篇 |
1977年 | 5篇 |
1974年 | 9篇 |
1973年 | 9篇 |
1972年 | 7篇 |
1971年 | 9篇 |
1970年 | 12篇 |
1969年 | 11篇 |
1968年 | 9篇 |
排序方式: 共有1145条查询结果,搜索用时 31 毫秒
11.
Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone 总被引:15,自引:0,他引:15
A R Midgley 《Endocrinology》1966,79(1):10-18
12.
BACKGROUND: Stress and corticotropin-releasing hormone inhibit the reproductive axis. We hypothesized that reproductive axis hormone secretion, particularly luteinizing hormone secretion, is inhibited in women with depression, similar to what has been observed to be caused by stress in numerous species. METHODS: Blood samples were collected every 10 minutes for 12 hours in 25 untreated premenopausal women with depression and 25 nondepressed women who were matched by age and menstrual cycle day. Samples were assayed for luteinizing hormone, follicle-stimulating hormone, estradiol, and progesterone. RESULTS: The mean plasma estradiol level was 30% lower in the follicular phase in women with depression than in their matched controls: 191 + 136 vs 261 + 169 pmol/L (52 + 37 vs 71 + 46 pg/mL). The half-life of luteinizing hormone was significantly shorter in women with depression than in their matched controls during both the follicular (22% shorter) and luteal (15% shorter) phases. CONCLUSIONS: The blood levels of reproductive hormones were mostly normal in women with depression, but the blood level of estradiol was significantly lower. Estradiol is known to affect a number of neurotransmitter systems in the brain. Arch Gen Psychiatry. 2000;57:1157-1162. 相似文献
13.
14.
Bevacizumab--current status and future directions. 总被引:13,自引:0,他引:13
Angiogenesis is crucial to tumour initiation, survival and metastasis. Vascular endothelial growth factor (VEGF) is one of the most important pro-angiogenic factors in cancer development. Bevacizumab (a humanised monoclonal antibody against VEGF) has a reasonable safety profile and proven efficacy in a phase III trial in advanced colorectal cancer. Efficacy of Bevacizumab also looks promising in non small cell lung cancer, renal cancer and a variety of other solid tumours. Questions still surround optimal dosing and the appropriate selection of patients who are most likely to benefit. Future trials will address these questions and provide further translational insights. 相似文献
15.
Luis O. Alonso-Ezpeleta Carmen Gasco-Garcia Lizett Castellanos-Cosano Jenifer Martín-González Francsico J. López-Frías Juan J. Segura-Egea 《Medicina oral, patología oral y cirugía bucal》2012,17(4):e721-e727
Objectives. To investigate and compare postoperative pain after one-visit root canal treatment (RCT) on teeth with vital pulps using three different obturation techniques.
Study Design. Two hundred and four patients (105 men and 99 women) aged 12 to 77 years were randomly assigned into three treatments groups: cold lateral compaction of gutta-percha (LC), Thermafil technique (TT), and Backfill - Thermafil obturation technique (BT). Postoperative pain was recorded on a visual analogue scale (VAS) of 0 - 10 after 2 and 6 hours, and 1, 2, 3, 4, 5, 6 and 7 days. Data were statistically analyzed using multivariate logistic regression analysis.
Results. In the total sample, 87% of patients experienced discomfort or pain in some moment between RCT and the seventh day. The discomfort experienced was weak, light, moderate and intense in 6%, 44%, 20% and 6% of the cases, respectively. Mean pain levels were 0.4 ± 0.4, 0.4 ± 0.3, and 1.4 ± 0.7 in LC, BT, and TT groups, respectively. Patients of TT group experienced a significantly higher mean pain level compared to other two groups (p < 0.0001). In TT group, all patients felt some level of pain at six hours after RCT.
Conclusions. Postoperative pain was significantly associated with the obturation technique used during root canal treatment. Patients whose teeth were filled with Thermafil obturators (TT technique) showed significantly higher levels of discomfort than patients whose teeth were filled using any of the other two techniques.
Key words:Postoperative pain, root-canal obturation, root-canal treatment, Thermafil. 相似文献
16.
Soares Mayara Sandrielly Pereira Viau Cassiana Macagnan Saffi Jenifer Costa Marcelo Zanusso da Silva Tatiane Morgana Oliveira Pathise Souto Azambuja Juliana Hofstatter Barschak Alethéa Gatto Braganhol Elizandra S Wyse Angela T Spanevello Roselia Maria Stefanello Francieli Moro 《Metabolic brain disease》2017,32(5):1693-1703
Metabolic Brain Disease - High plasma levels of methionine (Met) and its metabolites such as methionine sulfoxide (MetO) may occur in several genetic abnormalities. Patients with hypermethioninemia... 相似文献
17.
Thea K. Fischer Sofie Midgley Camilla Dalgaard Alex Y. Nielsen 《Emerging infectious diseases》2014,20(1):83-87
Human parechoviruses (HPeVs) often cause severe illness among young children. National surveillance with routine testing of all cerebrospinal fluid, fecal, and tissue samples was conducted during January 2009–December 2012 in all counties in Denmark (6,817 samples from 4,804 children were screened for HPeV). We detected HPeV RNA in 202 (3.0%) specimens from 149 persons. Young infants were at highest risk for HPeV, and 9 (6%) of the HPeV-infected children died, probably of their HPeV illness. HPeV3 was the most common genotype identified, and 5 closely related clades of HPeV3 circulated in Denmark throughout the study period. Our study adds perspective on the prevalence and clinical and molecular virologic characteristics of HPeV infection. 相似文献
18.
Paul H. Lysaker Bethany L. Leonhardt Martin Brüne Kelly D. Buck Alison James Jenifer Vohs Michael Francis Jay A. Hamm Giampaolo Salvatore Jamie M. Ringer Giancarlo Dimaggio 《Psychiatry research》2014
While many with schizophrenia spectrum disorders experience difficulties understanding the feelings of others, little is known about the psychological antecedents of these deficits. To explore these issues we examined whether deficits in mental state decoding, mental state reasoning and metacognitive capacity predict performance on an emotion recognition task. Participants were 115 adults with a schizophrenia spectrum disorder and 58 adults with substance use disorders but no history of a diagnosis of psychosis who completed the Eyes and Hinting Test. Metacognitive capacity was assessed using the Metacognitive Assessment Scale Abbreviated and emotion recognition was assessed using the Bell Lysaker Emotion Recognition Test. Results revealed that the schizophrenia patients performed more poorly than controls on tests of emotion recognition, mental state decoding, mental state reasoning and metacognition. Lesser capacities for mental state decoding, mental state reasoning and metacognition were all uniquely related emotion recognition within the schizophrenia group even after controlling for neurocognition and symptoms in a stepwise multiple regression. Results suggest that deficits in emotion recognition in schizophrenia may partly result from a combination of impairments in the ability to judge the cognitive and affective states of others and difficulties forming complex representations of self and others. 相似文献
19.
20.