全文获取类型
收费全文 | 199496篇 |
免费 | 50781篇 |
国内免费 | 8184篇 |
专业分类
耳鼻咽喉 | 2457篇 |
儿科学 | 5715篇 |
妇产科学 | 2873篇 |
基础医学 | 29735篇 |
口腔科学 | 7056篇 |
临床医学 | 28323篇 |
内科学 | 42679篇 |
皮肤病学 | 8715篇 |
神经病学 | 19655篇 |
特种医学 | 6345篇 |
外国民族医学 | 70篇 |
外科学 | 26301篇 |
综合类 | 18958篇 |
现状与发展 | 24篇 |
一般理论 | 25篇 |
预防医学 | 11804篇 |
眼科学 | 4906篇 |
药学 | 18058篇 |
115篇 | |
中国医学 | 7005篇 |
肿瘤学 | 17642篇 |
出版年
2024年 | 349篇 |
2023年 | 1847篇 |
2022年 | 4700篇 |
2021年 | 7088篇 |
2020年 | 9085篇 |
2019年 | 14448篇 |
2018年 | 13862篇 |
2017年 | 14775篇 |
2016年 | 15189篇 |
2015年 | 16789篇 |
2014年 | 17965篇 |
2013年 | 17975篇 |
2012年 | 12770篇 |
2011年 | 13571篇 |
2010年 | 14537篇 |
2009年 | 9743篇 |
2008年 | 8410篇 |
2007年 | 7267篇 |
2006年 | 7357篇 |
2005年 | 7103篇 |
2004年 | 5103篇 |
2003年 | 4866篇 |
2002年 | 4288篇 |
2001年 | 3997篇 |
2000年 | 4014篇 |
1999年 | 3726篇 |
1998年 | 2270篇 |
1997年 | 2188篇 |
1996年 | 1589篇 |
1995年 | 1479篇 |
1994年 | 1295篇 |
1993年 | 832篇 |
1992年 | 1261篇 |
1991年 | 1102篇 |
1990年 | 955篇 |
1989年 | 850篇 |
1988年 | 725篇 |
1987年 | 677篇 |
1986年 | 511篇 |
1985年 | 469篇 |
1984年 | 255篇 |
1983年 | 180篇 |
1982年 | 120篇 |
1981年 | 121篇 |
1980年 | 78篇 |
1979年 | 120篇 |
1978年 | 63篇 |
1976年 | 52篇 |
1975年 | 55篇 |
1974年 | 65篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
A case of untreated fusarial onychomycosis leading to serious consequences is reported. Fusarium solani is a widespread fungus and an occasional human pathogen. It usually invades rapidly in immunocompromised hosts, and often results in a poor outcome despite treatment. We report a woman with diabetes mellitus who had untreated fusarial infection of the nails, which developed into subcutaneous fusariosis, superinfected by bacteria, and then evolved into osteomyelitis that subsequently resulted in septic shock. Early management of mycotic nails in immunocompromised hosts is crucial to prevent life‐threatening disease. 相似文献
52.
Jing‐Ping Zhang Limin Zheng Jiang‐Hai Wang Karl‐Eric Magnusson Xin Liu 《Phytotherapy research : PTR》2009,23(6):844-850
Ganoderma sinensis has been used widely in Oriental countries for the prevention and treatment of various diseases including cancer. Previous studies have shown that the lipid extract from Ganoderma exhibits direct cytotoxicity against tumor cells. Here, it is reported that the lipid extract from germinating G. sinensis spores, at lower concentrations that have no direct tumoricidal activity, induce potent antitumor immune responses in human monocytes/macrophages. Upon stimulation with the lipid extract, monocytes/macrophages exhibited markedly increased production of proinflammatory cytokines and surface expression of costimulatory molecules. Conditioned medium from stimulated cells effectively suppressed the growth of tumor cells. Apparently, the lipid extract triggered macrophage activation via a mechanism different from that associated with LPS. Moreover, it was observed that the lipid extract could partially re‐establish the antitumor activity of the immunosuppressive tumor‐associated macrophages. These results indicated that in addition to its direct tumoricidal activity, the lipid extract from G. sinensis spores could exert antitumor activity by stimulating the activation of human monocytes/macrophages. Copyright © 2008 John Wiley & Sons, Ltd. 相似文献
53.
54.
55.
M P McMurry P N Hopkins R Gould K Engelbert-Fenton C Schumacher L L Wu R R Williams 《Journal of the American Dietetic Association》1991,91(1):57-65
We have developed a unique, family-oriented approach to lowering plasma cholesterol concentrations in persons with familial hyperlipidemias. The approach includes individual clinic visits and group nutrition classes and uses dietary goals outlined in The New American Diet. A series of 13 nutrition classes is presented to small groups, usually composed of relatives from pedigrees with familial hypercholesterolemia or other familial hyperlipidemias. Dietary action goals, cooking demonstrations, food tasting, and finger-stick plasma cholesterol determinations are important components of the classes. Problem-solving discussion is encouraged in the group. Over the past 4 years, 143 hyperlipidemic individuals, along with at least 94 unaffected family members, have participated in 31 groups, which have met for at least six classes. Many clinic participants lower plasma cholesterol by 20% or more. Keys to the success of this program include emphasizing dietary therapy, using the family setting for nutrition intervention, providing hands-on experience with food and recipes, promoting problem solving for dietary action goals, measuring blood cholesterol during classes, and encouraging long-term follow-up for participants with physicians and dietitians. 相似文献
56.
57.
Henry Ho‐Lung Chan 《Clinical & experimental optometry》2005,88(6):410-414
The first‐order kernel analysis in multifocal electroretinogram (mfERG) using low contrast stimulation is suggested as a way to detect the inner retinal responses in animal studies. In this case report, this protocol is applied to human patients with glaucoma to demonstrate the possibility of using mfERG as a tool to detect glaucomatous damage. Two patients with glaucoma were recruited and had mfERG measurements with the 103‐scaled hexagonal stimulus pattern at low (50 per cent) contrast. Their responses were analysed and compared with those from normal subjects with the mfERG measured under the same condition. In the normal subjects, there were obvious oscillatory components on the ascending and descending limbs of the first‐order kernel response to 50 per cent contrast. In the glaucomatous patients, the oscillatory component on the descending limb was obviously diminished. In addition, this component was significantly diminished in the quadrant with a glaucomatous visual field defect. This suggests that the low‐contrast stimulation condition in mERG measurement may provide a good way to detect glaucomatous damage and this may help in clinical diagnosis of glaucoma. 相似文献
58.
BACKGROUND AND PURPOSE: Thyroidectomy is a common treatment for thyroid disorders in Taiwan, and constitutes a significant percentage of medical expenses. This study investigated the characteristics of thyroidectomy in Taiwan. METHODS: A total of 21 senior general surgeons from 16 medical centers and 5 regional hospitals participated. One surgeon from each hospital reviewed the hospital's medical records of thyroid operations performed in the year 2001. Medical records for 3846 thyroidectomies were retrospectively analyzed, including surgical indications and modalities, complications, pathology reports, and the use of antibiotics. RESULTS: Most of the patients were women (85%). Indications for surgery included proven malignancy (9%), suspicious malignancy (30%), evident compression symptoms (20%), hyperthyroidism (20%), and cosmetic reasons (12%). The majority of patients (78%) underwent a surgical procedure with lobectomy or bilateral thyroidectomy; 13% had unilateral partial thyroidectomy. Prophylactic antibiotics were administered in 46% of procedures, and continued postoperatively in 12%. Postoperative complications occurred in 12% of patients. Hypocalcemia was the most common complication (8%), and its incidence was significantly correlated with the frequency of total thyroidectomy (p < 0.01). Complete pathology reports for the thyroidectomized specimens were available in only 65% of the cases. The frequency of cosmetic reasons for surgery, unilateral subtotal resection, routine antibiotic administration, and incomplete pathology reports were significantly higher in regional hospitals than in medical centers. CONCLUSIONS: Reduction in the high rates of cosmetic reasons for surgery, unilateral partial thyroidectomy, incomplete pathology reports, and use of antibiotic prophylaxis are needed to improve the quality of thyroidectomy in Taiwan. 相似文献
59.
Pneumocephalus is a very rare complication of video-assisted thoracoscopic surgery (VATS). A 66-year-old man developed pneumocephalus secondary to thoracoscopic excision of a neurogenic tumor in the posterior mediastinum. Pneumocephalus was diagnosed by brain computed tomography. Neurosurgical intervention was performed after conservative therapy had failed. The patient's condition had resolved without any neurologic sequelae 2 years later. When a patient has a relatively large amount of chest tube drainage and neurologic symptoms after VATS, the possibility of pneumocephalus due to cerebrospinal fluid leakage must be considered. 相似文献
60.