全文获取类型
收费全文 | 5506篇 |
免费 | 413篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 164篇 |
妇产科学 | 101篇 |
基础医学 | 704篇 |
口腔科学 | 71篇 |
临床医学 | 798篇 |
内科学 | 915篇 |
皮肤病学 | 104篇 |
神经病学 | 520篇 |
特种医学 | 163篇 |
外科学 | 602篇 |
综合类 | 62篇 |
一般理论 | 2篇 |
预防医学 | 823篇 |
眼科学 | 107篇 |
药学 | 309篇 |
中国医学 | 4篇 |
肿瘤学 | 456篇 |
出版年
2023年 | 28篇 |
2022年 | 45篇 |
2021年 | 102篇 |
2020年 | 72篇 |
2019年 | 93篇 |
2018年 | 112篇 |
2017年 | 95篇 |
2016年 | 86篇 |
2015年 | 119篇 |
2014年 | 146篇 |
2013年 | 213篇 |
2012年 | 295篇 |
2011年 | 363篇 |
2010年 | 205篇 |
2009年 | 166篇 |
2008年 | 300篇 |
2007年 | 329篇 |
2006年 | 302篇 |
2005年 | 299篇 |
2004年 | 255篇 |
2003年 | 301篇 |
2002年 | 239篇 |
2001年 | 124篇 |
2000年 | 108篇 |
1999年 | 106篇 |
1998年 | 75篇 |
1997年 | 51篇 |
1996年 | 56篇 |
1995年 | 60篇 |
1994年 | 38篇 |
1993年 | 30篇 |
1992年 | 63篇 |
1991年 | 60篇 |
1990年 | 62篇 |
1989年 | 73篇 |
1988年 | 55篇 |
1987年 | 61篇 |
1986年 | 54篇 |
1985年 | 56篇 |
1984年 | 47篇 |
1983年 | 48篇 |
1982年 | 29篇 |
1981年 | 27篇 |
1979年 | 37篇 |
1978年 | 38篇 |
1974年 | 26篇 |
1973年 | 31篇 |
1971年 | 28篇 |
1969年 | 32篇 |
1966年 | 27篇 |
排序方式: 共有5924条查询结果,搜索用时 15 毫秒
81.
82.
83.
84.
An interview‐based study of nonattendance at screening for cardiovascular diseases and diabetes in older women: Nonattendees’ perspectives 下载免费PDF全文
85.
86.
Hong Chee Chew Arjun Iyer Mark Connellan Sarah Scheuer Jeanette Villanueva Ling Gao Mark Hicks Michelle Harkness Claudio Soto Andrew Dinale Priya Nair Alasdair Watson Emily Granger Paul Jansz Kavitha Muthiah Andrew Jabbour Eugene Kotlyar Anne Keogh Kumud Dhital 《Journal of the American College of Cardiology》2019,73(12):1447-1459
Background
Transplantation of hearts retrieved from donation after circulatory death (DCD) donors is an evolving clinical practice.Objectives
The purpose of this study is to provide an update on the authors’ Australian clinical program and discuss lessons learned since performing the world’s first series of distantly procured DCD heart transplants.Methods
The authors report their experience of 23 DCD heart transplants from 45 DCD donor referrals since 2014. Donor details were collected using electronic donor records (Donate Life, Australia) and all recipient details were collected from clinical notes and electronic databases at St. Vincent’s Hospital.Results
Hearts were retrieved from 33 of 45 DCD donors. A total of 12 donors did not progress to circulatory arrest within the pre-specified timeframe. Eight hearts failed to meet viability criteria during normothermic machine perfusion, and 2 hearts were declined due to machine malfunction. A total of 23 hearts were transplanted between July 2014 and April 2018. All recipients had successful implantation, with mechanical circulatory support utilized in 9 cases. One case requiring extracorporeal membrane oxygenation subsequently died on the sixth post-operative day, representing a mortality of 4.4% over 4 years with a total follow-up period of 15,500 days for the entire cohort. All surviving recipients had normal cardiac function on echocardiogram and no evidence of acute rejection on discharge. All surviving patients remain in New York Heart Association functional class I with normal biventricular function.Conclusions
DCD heart transplant outcomes are excellent. Despite a higher requirement for mechanical circulatory support for delayed graft function, primarily in recipients with ventricular assist device support, overall survival and rejection episodes are comparable to outcomes from contemporary brain-dead donors. 相似文献87.
Kun Sun Jeanette Br?ms Moa Lavander Bharat Kumar Gurram Per-Anders Enquist C. David Andersson Mikael Elofsson Anders Sj?stedt 《Antimicrobial agents and chemotherapy》2014,58(7):4123-4130
The type VI secretion system (T6SS) is the most prevalent bacterial secretion system and an important virulence mechanism utilized by Gram-negative bacteria, either to target eukaryotic cells or to combat other microbes. The components show much variability, but some appear essential for the function, and two homologues, denoted VipA and VipB in Vibrio cholerae, have been identified in all T6SSs described so far. Secretion is dependent on binding of an α-helical region of VipA to VipB, and in the absence of this binding, both components are degraded within minutes and secretion is ceased. The aim of the study was to investigate if this interaction could be blocked, and we hypothesized that such inhibition would lead to abrogation of T6S. A library of 9,600 small-molecule compounds was screened for their ability to block the binding of VipA-VipB in a bacterial two-hybrid system (B2H). After excluding compounds that showed cytotoxicity toward eukaryotic cells, that inhibited growth of Vibrio, or that inhibited an unrelated B2H interaction, 34 compounds were further investigated for effects on the T6SS-dependent secretion of hemolysin-coregulated protein (Hcp) or of phospholipase A1 activity. Two compounds, KS100 and KS200, showed intermediate or strong effects in both assays. Analogues were obtained, and compounds with potent inhibitory effects in the assays and desirable physicochemical properties as predicted by in silico analysis were identified. Since the compounds specifically target a virulence mechanism without affecting bacterial replication, they have the potential to mitigate the virulence with minimal risk for development of resistance. 相似文献
88.
89.