全文获取类型
收费全文 | 11645篇 |
免费 | 596篇 |
国内免费 | 46篇 |
专业分类
耳鼻咽喉 | 144篇 |
儿科学 | 236篇 |
妇产科学 | 194篇 |
基础医学 | 1767篇 |
口腔科学 | 248篇 |
临床医学 | 1097篇 |
内科学 | 2677篇 |
皮肤病学 | 106篇 |
神经病学 | 1325篇 |
特种医学 | 388篇 |
外科学 | 1677篇 |
综合类 | 84篇 |
一般理论 | 3篇 |
预防医学 | 669篇 |
眼科学 | 85篇 |
药学 | 784篇 |
中国医学 | 13篇 |
肿瘤学 | 790篇 |
出版年
2022年 | 49篇 |
2021年 | 140篇 |
2020年 | 84篇 |
2019年 | 145篇 |
2018年 | 157篇 |
2017年 | 108篇 |
2016年 | 116篇 |
2015年 | 185篇 |
2014年 | 228篇 |
2013年 | 321篇 |
2012年 | 613篇 |
2011年 | 679篇 |
2010年 | 338篇 |
2009年 | 370篇 |
2008年 | 654篇 |
2007年 | 724篇 |
2006年 | 778篇 |
2005年 | 834篇 |
2004年 | 754篇 |
2003年 | 784篇 |
2002年 | 694篇 |
2001年 | 219篇 |
2000年 | 230篇 |
1999年 | 226篇 |
1998年 | 217篇 |
1997年 | 175篇 |
1996年 | 146篇 |
1995年 | 117篇 |
1994年 | 135篇 |
1993年 | 107篇 |
1992年 | 162篇 |
1991年 | 135篇 |
1990年 | 144篇 |
1989年 | 122篇 |
1988年 | 140篇 |
1987年 | 134篇 |
1986年 | 103篇 |
1985年 | 103篇 |
1984年 | 80篇 |
1983年 | 60篇 |
1982年 | 66篇 |
1981年 | 70篇 |
1980年 | 53篇 |
1979年 | 61篇 |
1978年 | 42篇 |
1977年 | 43篇 |
1975年 | 39篇 |
1974年 | 47篇 |
1973年 | 49篇 |
1971年 | 40篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
11.
Reaming versus non-reaming in medullary nailing: Interference with cortical circulation of the canine tibia 总被引:13,自引:2,他引:11
M. P. M. Klein B. A. Rahn R. Frigg S. Kessler S. M. Perren 《Archives of orthopaedic and trauma surgery》1990,109(6):314-316
Summary Medullary nails have only been used with reluctance in the treatment of open fractures since reaming interferes with the cortical circulation. The technique of interlocking offers the interesting possibility of inserting a relatively stiff nail which does not necessarily require reaming. The effects of reaming prior to nail insertion upon the cortical circulation was investigated in the canine tibia. Intravital staining with procion red was used to trace areas of disturbed circulation. Nail insertion without reaming provided clear advantages for the bone's blood supply, while reaming disturbed perfusion in two-thirds of the cortical area and regionally extended through the entire thickness of the cortex. The disturbance without reaming was limited to the inner layer of the cortex and involved only one-third of the cortical cross-section. 相似文献
12.
13.
Mario Sénéchal Isabelle Lemieux Isabel Beucler Gerard Drobinski Sylvie Cormont Michelle Dubois Iradj Gandjbakhch Jean-Pierre Després Richard Dorent 《The Journal of heart and lung transplantation》2005,24(7):819-826
BACKGROUND: This study evaluated the prevalence of the atherogenic metabolic triad and the hypothesis that waist circumference and fasting triglyceride concentrations could be used as screening tools for identification of the atherogenic metabolic triad in a population of heart transplant men. It also evaluated the relationship between the atherogenic metabolic triad and coronary artery disease (CAD). METHODS: In the study group of 83 consecutive male heart transplant patients having their routine annual coronarography, 23 patients (28%) were characterized by the atherogenic metabolic triad defined by the presence of elevated fasting insulin and apolipoprotein B concentrations and by small low-density lipoprotein (LDL) particles. RESULTS: Seventy-seven per cent of patients with waist circumference values >/= 90 cm and with elevated triglyceride levels (>/=2.0 mmol/liter) were characterized by this atherogenic metabolic triad. Patients with the atherogenic metabolic triad were at markedly increased risk of CAD (odds ratio of 25.3, 95% CI: 1.11-577.3, p < 0.04) compared to heart transplant patients without the atherogenic metabolic triad. CONCLUSIONS: About 30% of heart transplant patients showed the features of the atherogenic metabolic triad. Measurement and interpretation of waist circumference and fasting triglycerides could be used among heart transplant patients to early identify men characterized by the presence of elevated fasting insulin and apolipoprotein B concentrations and small LDL particles. The presence of the atherogenic metabolic triad identified patients at high risk of CAD even in the heart transplant population. 相似文献
14.
Jean-Pierre Chanoine MD PhD Sarah Hampl MD FAAP Craig Jensen MD Mark Boldrin MS Jonathan Hauptman MD 李呈亿 《美国医学会杂志》2006,25(1):34-43
背景:儿童和青少年超重和肥胖正迅速增加。在该人群,单纯行为疗法减肥及维持体重下降的效果有限,但是对药物治疗尚未进行广泛的研究。
目的:确定奥利州他(Orlistat)在青少年体重治疗方面的效果及其安个性。
设计、地点和病例:于美国和加拿大32个中心、539例肥胖青少年(12—16岁;体重指数[body mass index,BMI]在第95百分化之上≥2单位)进行的多ln0、54剧(2000年8月至2002年10月)随机双盲研究。
干预:给予奥利司他(n=357)或安慰剂(n=182)120mg,每口3次,持续1年;加适度低热卡饮食(脂肪占30%)、运动和行为治疗。
主要观察指标:BMI变化;二级指标包括腰围和髋用、体重下降、脂质测量以及机体对口服葡萄糖的血糖和胰岛素反心。
结果:至12周时,两组BMI均有下降;此后,奥利司他组体重维持稳定而安慰剂组则超过基线。研究结束时,奥利司他组BMI下降0.55。而安慰剂组则增加0.31(P=0.001)。与安慰剂组的15.7%相比,奥利司他组26.5%的病例BMI下降≥5%(P=0.005);BMI下降≥10%者分别为4.5%和13.3%(P=0.002)。在研究结束时,奥利司他组体重增加0.53kg,安慰剂组增加3.14kg(P〈0.001)。双能X线吸收测量娃示,这种差异可用脂肪体再的变化解释。奥利司他组腰围下降,安慰剂组腰围上升(-1.33cm比+0.12cm;P〈0.05)。奥利司他组发生轻至中度胃肠道不良事件者为9%-50%,安慰剂组为1%~13%。
结论:与安慰剂比较,奥利司他与饮食、运动和行为改善联合可显著改善肥胖青少年体重的治疗。在这个青少年人群,连续使用奥利司他1年并无重要安全问题,尽管奥利司他组胃肠道不良事件较为常见。 相似文献
15.
16.
Decreased stability of triglycerides and increased free glycerol in serum from heparin-treated patients 总被引:1,自引:0,他引:1
Triglycerides usually are stable in serum. However, for a few patients, we noted marked decreases in measured triglycerides when the same serum specimen was analyzed on successive days. This was found to be ascribable to intravenous administration of heparin. Measured triglyceride in serum of 11 patients being treated with heparin decreased 34% (SD 17%) in samples stored for one day at room temperature. Triglyceride values for sera from control patients remained unchanged. Increases in free glycerol corresponded to the observed decreased in triglycerides. Measurement of free glycerol thus provides a means of recognizing this problem. 相似文献
17.
18.
19.
E. W. Brien Joseph M. Mirra Steven Kessler M. Suen J. K. S. Ho W. T. Yang 《Skeletal radiology》1997,26(4):246-255
It is not uncommon for sarcomatous transformation of giant cell tumor (GCT) of bone to occur after radiation, but rarely
does malignant transformation occur spontaneously, with less than 15 cases reported up to 1995. Only four of these cases have
been documented in detail. We report two additional cases of GCT of bone spontaneously transforming or ”dedifferentiating”
into osteosarcoma without radiation therapy. The first case is absolutely unique and most interesting in that the dedifferentiation
process occurred in one of multiple GCT lung metastases 6 years after successful eradication of a primary tibial tumor. The
right lung was resected due to development of a large tumor, and at pathologic examination, demonstrated several small nodules
of conventional GCT and a much larger, 14-cm mass composed of a mixture of GCT and high-grade osteosarcoma. The second case
involved a physician, who had a large tumor in the sacrum with vague symptoms for 8 years. Open biopsy revealed conventional,
benign GCT of bone with a secondary aneurysmal bone cyst. Complete curettage 2 weeks later revealed, in addition to areas
of conventional, benign GCT a second component of very high grade osteosarcoma. Both patients died less than 1.5 years from
diagnosis. This report of osteosarcomatous transformation of a conventional GCT of bone strengthens the theory that there
is a mesenchymal cell line in GCT that may spontaneously tansform to sarcoma. 相似文献