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91.
Hoare Jacqueline Heany Sarah J. Fouche Jean-Paul Phillips Nicole Joska John A. Myer Landon Zar Heather J. Stein Dan J. 《Journal of neurovirology》2019,25(2):254-262
Journal of NeuroVirology - Rapid maturation of major white matter pathways occurs in the first 2 years of life, indicating a critical neuronal developmental period. The impact of... 相似文献
92.
Paganin F Bourdin A Dalban C Courtin JP Poubeau P Borgherini G Michault A Sally JC Tixier F Genin R Arvin-Berod C 《Intensive care medicine》2007,33(11):1959-1966
Objective Analysis of risk factors associated with severity in patients with confirmed leptospirosis.
Design and setting Retrospective study in 147 leptospirosis-confirmed patients at two tertiary nonteaching hospital in Reunion Island.
Patients 138 men and 9 women, aged 36 ± 14 years, 80 in the ICU and 67 in medical wards.
Measurements and results We collected demographic, clinical, biological, and radiographic data and performed univariate and multivariate analysis to
examine risk factors associated with admission in ICU and mortality. Pulmonary forms were more frequent (85%) than in previous
reports, with 85 cases (65.3%) on abnormal chest radiography. Among the 38 patients who underwent bronchoalveolar lavage at
admission 31 (81.5%) had alveolar hemorrhage. Independent factors related to ICU admission were: age over 46 years (OR 3.02),
creatinine higher than 200 μmol/l (6.69), shock (13.87), and acute respiratory failure (20.69). Mortality was 12.9%. The only
factor independently related to mortality was need for mechanical ventilation (OR 20.94). Icterohemorrhagiae serogroup was found in 62 cases (42.8%) but was not related to death.
Conclusions Pulmonary involvement is a major feature in leptospirosis disease but is not associated with poor outcome. Identification
of clinical and laboratory findings on admission may help to better characterize severe cases.
Mailing address: Arnaud Bourdin is currently at the Service de Pneumologie, CHU Montpellier, France. 相似文献
93.
Daniel Ciampi de Andrade Belgacem Bendib Mohammed Hattou Yves Keravel Jean-Paul Nguyen Jean-Pascal Lefaucheur 《Pain》2010
Despite good clinical results, the mechanisms of action of spinal cord stimulation (SCS) for the treatment of chronic refractory neuropathic pain have not yet been elucidated. In the present study, the effects of SCS were assessed on various neurophysiological parameters in a series of 20 patients, successfully treated by SCS for mostly unilateral, drug-resistant lower limb pain due to failed back surgery syndrome. Plantar sympathetic skin response (SSR), F-wave and somatosensory-evoked potentials (P40-SEP) to tibial nerve stimulation, H-reflex of soleus muscle, and nociceptive flexion (RIII) reflex to sural nerve stimulation were recorded at the painful lower limb. The study included two recording sets while SCS was switched ‘ON’ or ‘OFF’ for 1 h. Significant changes in ‘ON’ condition were as follows: SSR amplitude, H-reflex threshold, and RIII-reflex threshold and latency were increased, whereas SSR latency, F-wave latency, H-reflex amplitude, P40-SEP amplitude, and RIII-reflex area were reduced. Analgesia induced by SCS mainly correlated with RIII attenuation, supporting a real analgesic efficacy of the procedure. This study showed that SCS is able to inhibit both nociceptive (RIII-reflex) and non-nociceptive (P40-SEP, H-reflex) myelinated sensory afferents at segmental spinal or supraspinal level, and to increase cholinergic sympathetic skin activities (SSR facilitation). Complex modulating effects can be produced by SCS on various neural circuits, including a broad inhibition of both noxious and innocuous sensory information processing. 相似文献
94.
Julien Obiols Anne-Sophie Bargnoux Nils Kuster Pierre Fesler Laurence Piéroni Stéphanie Badiou Anne-Marie Dupuy Jean Ribstein Jean-Paul Cristol 《Clinical biochemistry》2013
Objectives
Analytical and clinical performances of the new standardized cystatin C particle-enhanced turbidimetric immunoassay (PETIA) using DiaSys reagents on Olympus AU2700® analyzer were evaluated.Design and methods
We have studied imprecision, linearity, limit of detection and limit of quantification of this new immunoassay. Method comparison was assessed in relation to results generated by the standardized Siemens-particle-enhanced nephelometric immunoassay (PENIA). In order to evaluate the clinical relevance of this assay, estimated glomerular filtration rate (GFR) was calculated using MDRD, CKD-EPI creatinine, CKD-EPI cystatin C 2012 and CKD-EPI creatinine–cystatin C 2012 equations and compared to GFR measured using urinary clearance of 99mTc-DTPA in 100 hypertensive patients.Results
Cystatin C measurements using DiaSys reagents have reliable analytical performances and are comparable to the standardized Siemens-PENIA method (bias of 0.01 mg/L). The mean measured GFR was 90.0 ± 29.7 mL/min/1.73 m2. Bias and accuracy of the three CKD-EPI equations were better than the MDRD. Both CKD-EPI creatinine-based and cystatin C-based formulae had similar bias, precision and accuracy. The combined creatinine–cystatin C equation was significantly more accurate and precise than the CKD-EPI creatinine equation in patients with GFR above 60 mL/min/1.73 m2.Conclusions
The use of cystatin C in a combined equation with creatinine could improve the accuracy of eGFR in the reference interval. 相似文献95.
Caroline Courtais Nils Kuster Anne-Marie Dupuy Margit Folschveiller Riad Jreige Anne-Sophie Bargnoux Julie Guiot Sophie Lefebvre Jean-Paul Cristol Mustapha Sebbane 《The American journal of emergency medicine》2013
The aim of the present study was, first, to evaluate the prognostic value of mid-regional proadrenomedullin (proADM) in emergency department (ED) patients with a diagnosis of community acquired pneumonia (CAP) and, second, to analyze the added value of proADM as a risk stratification tool in comparison with other biomarkers and clinical severity scores. 相似文献
96.
Beregi JP Mounier-Vehier C Devos P Gautier C Libersa C McFadden EP Carré A 《Cardiovascular and interventional radiology》2000,23(5):340-346
Purpose: To study the vasomotor responses of the renal microcirculation in patients with essential hypertension.
Methods: We studied the reactivity of the renal microcirculation to papaverine, with intraarterial Doppler and quantitative arteriography,
in 34 renal arteries of 19 hypertensive patients without significant renal artery stenosis. Isosorbide dinitrate was given
to maximally dilate proximal renal arteries. APV (average peak blood flow velocity) was used as an index of renal blood flow.
Results: Kidneys could be divided into two distinct subgroups based on their response to papaverine. An increase in APV of up to 55%
occurred in 21 kidneys, an increase > 55% in 13 kidneys. Within each group the values were normally distributed. Both baseline
APV and the effect of papaverine on mean velocity differed significantly between groups.
Conclusion: There seems to be a subgroup of patients with essential hypertension that has an impaired reactivity to papaverine, consistent
with a functional impairment of the renal microcirculation. Further studies are required to determine whether this abnormality
contributes to or results from elevated blood pressure. 相似文献
97.
98.
Mathieu MC Bonhomme-Faivre L Rouzier R Seiller M Barreau-Pouhaer L Travagli JP 《Annals of surgical oncology》2007,14(8):2233-2238
Background In breast carcinomas treated with neoadjuvant chemotherapy, intraoperative identification of residual tumors may be difficult.
A well-tolerated, low-diffusion charcoal suspension has been designed to tattoo breast tumors. In this study, we investigated
whether this tattooing technique is efficient for localizing the tumor after treatment with chemotherapy.
Methods In a series of 109 patients with large breast tumors, a 4% or 10% charcoal suspension was injected at the time of the initial
biopsy before preoperative chemotherapy.
Results Tolerance was good. After three or four cycles of chemotherapy, 91 patients underwent conservative treatment, and the surgical
specimen was examined intraoperatively. The charcoal was detected in 94% of the cases. The charcoal was seen in the nodule
or at the periphery in the surgical specimen without any acute inflammatory reaction or diffusion.
Conclusions On the basis of these results, this micronized charcoal suspension at a defined granulometry and a concentration of 10% seems
to be ideal for tattooing breast carcinomas over a period of 3 months in patients in whom neoadjuvant chemotherapy is planned. 相似文献
99.
Abnormalities of ventricular relaxation and compliance often precede changes in systolic function in ischemic and hypertrophic or hypertensive heart disease. Several studies using non-invasive methods have confirmed the beneficial effects of calcium channel blockers on left ventricular diastolic function in ischemic and primary hypertrophic cardiomyopathies. Their usefulness remains controversial in secondary cardiac hypertrophy such as in hypertensive heart disease. Improved left ventricular isovolumic relaxation and filling results more from the coronary and peripheral vasodilatory effects of calcium channel blockers than from a direct action on the cardiac muscle. 相似文献
100.
Pierre Bordigoni Hélène Esperou Gérard Souillet JosÉ Pico Gérard Michel Brigitte Lacour Josy Reiffers Alain Sadoun Pierre Rohrlich Jean-Pierre Jouet Noël Milpied Patrick Lutz Emmanuel Plouvier Guy Cornu Jean-Pierre Vannier Virginie Gandemer HervÉ Rubie Nicole Gratecos Guy Leverger Jean-Louis Stephan Patrice Boutard & Jean-Paul Vernant 《British journal of haematology》1998,102(3):656-665
We investigated the use of a new conditioning regimen followed by allogeneic bone marrow transplantation (BMT) for treating children with acute lymphoblastic leukaemia (ALL) after relapse within 6 months of the completion of therapy. One hundred and sixteen children with acute lymphoblastic leukaemia in second or subsequent complete remission (CR) underwent allogeneic bone marrow transplantation from HLA-identical siblings after a preparative regimen comprising total body irradiation (TBI), high-dose cytosine arabinoside and melphalan (TAM regimen). The Kaplan-Meier product-limit estimate (mean ± SE) of disease-free survival (DFS) at 7 years was 59.5 ± 9% (95% confidence interval). The estimated chance of relapse was 22.5 ± 15% with a median follow-up of 88.5 months (range 51–132). 26 patients (22.4%) died with no evidence of recurrent leukaemia, mainly from interstitial pneumonitis, veno-occlusive disease or acute graft-versus-host disease (GVHD). Three factors significantly affected DFS: acute GVHD, site of relapse and, for children in second remission after a marrow relapse, the disease status at the time of transplantation. The DFS were 59.02 ± 12.6%, 37.5 ± 19.8% and 77.4 ± 15% among patients in CR2 after a marrow relapse, in CR3 or in untreated partial marrow relapse, and in CR2 after an isolated CNS relapse, respectively. The lowest DFS was seen in children with acute GVHD grades 3–4. Two significant factors were associated with relapse: the marrow status at the time of transplantation and chronic GVHD. The relapse rate was lower among children in CR2 or with chronic GVHD. We conclude that transplantation after the TAM regimen is an effective therapy for this population with acceptable toxicity, particularly for children in second remission after a very early marrow relapse, or those with early isolated CNS involvement. 相似文献