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101.
Galmiche L Vasiliu V Poirée S Hélénon O Casanova JM Brousse N 《Annales de pathologie》2007,27(5):365-368
Most renal tumors of the adult are carcinomas. Their treatment is surgical, consisting of limited excision or nephrectomy. In some instances, biopsy of the tumor can be performed in order to adapt treatment. We report the case of a 45 year-old woman presenting with renal tumor. A biopsy of the mass showed a metanephric adenoma. No surgical excision was performed because of the benignity of this tumor. Here we develop the interest of immunohistochemistry for differential diagnosis of metanephric adenoma and other "basophilic small cell tumors" of the kidney. We also put the stress on the growing role of biopsy of renal tumor allowing optimal treatment. 相似文献
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Pascale Gauthier Jean-Michel Cardot Erick Beyssac Jean-Marc Aiache 《Pharmaceutical development and technology》2018,23(6):655-662
AbstractDifferent previous works have shown that various kinds of spheres can be manufactured by rotor granulation in a ‘single-pot process’ using a lipid base: hydrogenated castor oil. This single-pot technology is based on wet granulation where all components are placed in the powder form in the rotor bowl; then, they are continuously suspended in a fluidized air, with a tangentially sprayed liquid solution. This process allows the granulation and manufacturing of sphere during the same time. Previous experiments have studied the influence of the formulation and the manufacturing process parameters on spheres in terms of feasibility and dissolution properties. Both the spraying time and the weight of liquid sprayed were found to be the most relevant parameters that govern the final quality of the sphere. Now, in a second part of the work, a first comparison is made with two different fluid bed methods: the tangential rotor spray and the Wurster bottom spray for coating the lipid spheres previously manufactured with the rotor tangential spray. The external aspect of the coated spheres manufactured has been evaluated with an electronic microscopy analysis and a study of dissolution properties of the active ingredient has been done by USP in vitro dissolution tests. 相似文献
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Chlo Dimeglio Marine Milhes Jean-Michel Loubes Nomie Ranger Jean-Michel Mansuy Pauline Trmeaux Nicolas Jeanne Justine Latour Florence Nicot Ccile Donnadieu Jacques Izopet 《Viruses》2021,13(5)
The spread of SARS-CoV-2 and the resulting disease COVID-19 has killed over 2.6 million people as of 18 March 2021. We have used a modified susceptible, infected, recovered (SIR) epidemiological model to predict how the spread of the virus in regions of France will vary depending on the proportions of variants and on the public health strategies adopted, including anti-COVID-19 vaccination. The proportion of SARS-CoV-2 variant B.1.1.7, which was not detected in early January, increased to become 60% of the forms of SARS-CoV-2 circulating in the Toulouse urban area at the beginning of February 2021, but there was no increase in positive nucleic acid tests. Our prediction model indicates that maintaining public health measures and accelerating vaccination are efficient strategies for the sustained control of SARS-CoV-2. 相似文献
107.
Nathalie De Castro Olivier Marcy Corine Chazallon Eugène Messou Serge Eholié Jean-Baptiste N'takpe Nilesh Bhatt Celso Khosa Isabel Timana Massango Didier Laureillard Giang Do Chau Anaïs Domergue Valdilea Veloso Rodrigo Escada Sandra Wagner Cardoso Constance Delaugerre Xavier Anglaret Jean-Michel Molina 《The Lancet infectious diseases》2021,21(6):813-822
108.
Emmanuel Teiger MD PhD Jean-Benoit Thambo MD PhD Pascal Defaye MD Jean-Sylvain Hermida MD Sélim Abbey MD Didier Klug MD PhD Jean-Michel Juliard MD Christian Spaulding MD PhD Sébastien Armero MD Didier Champagnac MD Hamza Bhugaloo MS Julien Ternacle MD PhD Nicolas Lellouche MD PhD Etienne Audureau MD PhD Philippe Le Corvoisier MD PhD the French national Left Atrial Appendage Closure registry investigators 《Catheterization and cardiovascular interventions》2021,98(4):788-799
109.
Romain Siriez Jean-Michel Dogné Robert Gosselin Julie Laloy François Mullier Jonathan Douxfils 《International journal of laboratory hematology》2021,43(1):7-20
There is a laboratory and clinical need to know the impact of direct oral anticoagulants (DOACs) on diagnostic tests to avoid misinterpretation of results. Although the regulatory labelling documents provide some information about the influences of each DOAC on diagnostic tests, these are usually limited to some of the most common tests and no head to head comparison is available. In this paper, we report the impact of DOACs on several thrombophilia tests, including assessment of antithrombin, protein S and protein C activity assays, detection of activated protein C resistance and assays used for lupus anticoagulant. Results are compared and discussed with data obtained from literature. The final goal of this comprehensive review is to provide practical recommendations for laboratories to avoid misdiagnosis due to oral direct factor Xa (FXa) or IIa (FIIa) inhibitors. Overall, oral direct FXa (apixaban, betrixaban, edoxaban and rivaroxaban) and FIIa (dabigatran) antagonists may affect clot-based thrombophilia diagnostic tests resulting in false-positive or false-negative results. An effect on FIIa-based thrombophilia diagnostic tests is observed with dabigatran but not with anti-FXa DOACs and conversely for FXa-based thrombophilia diagnostic tests. No impact was observed with antigenic/chromogenic methods for the assessment of protein S and C activity. In conclusion, interpretation of thrombophilia diagnostic tests results should be done with caution in patients on DOACs. The use of a device/chemical compound able to remove or antagonize the effect of DOACs or the development of new diagnostic tests insensitive to DOACs should be considered to minimize the risk of false results. 相似文献