全文获取类型
收费全文 | 1230篇 |
免费 | 102篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 24篇 |
儿科学 | 26篇 |
妇产科学 | 14篇 |
基础医学 | 138篇 |
口腔科学 | 9篇 |
临床医学 | 108篇 |
内科学 | 340篇 |
皮肤病学 | 9篇 |
神经病学 | 120篇 |
特种医学 | 55篇 |
外科学 | 252篇 |
综合类 | 11篇 |
预防医学 | 75篇 |
眼科学 | 14篇 |
药学 | 60篇 |
中国医学 | 8篇 |
肿瘤学 | 75篇 |
出版年
2023年 | 10篇 |
2022年 | 24篇 |
2021年 | 63篇 |
2020年 | 22篇 |
2019年 | 42篇 |
2018年 | 44篇 |
2017年 | 24篇 |
2016年 | 16篇 |
2015年 | 31篇 |
2014年 | 49篇 |
2013年 | 80篇 |
2012年 | 111篇 |
2011年 | 107篇 |
2010年 | 49篇 |
2009年 | 32篇 |
2008年 | 81篇 |
2007年 | 66篇 |
2006年 | 65篇 |
2005年 | 56篇 |
2004年 | 52篇 |
2003年 | 52篇 |
2002年 | 62篇 |
2001年 | 18篇 |
2000年 | 9篇 |
1999年 | 13篇 |
1998年 | 3篇 |
1997年 | 9篇 |
1996年 | 8篇 |
1995年 | 11篇 |
1994年 | 11篇 |
1993年 | 5篇 |
1992年 | 10篇 |
1991年 | 5篇 |
1990年 | 6篇 |
1989年 | 7篇 |
1988年 | 6篇 |
1987年 | 6篇 |
1986年 | 9篇 |
1985年 | 17篇 |
1984年 | 10篇 |
1983年 | 4篇 |
1981年 | 3篇 |
1980年 | 2篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1977年 | 3篇 |
1975年 | 3篇 |
1974年 | 2篇 |
1971年 | 3篇 |
1968年 | 2篇 |
排序方式: 共有1338条查询结果,搜索用时 281 毫秒
21.
22.
Steroidogenic activity of fragments of adrenocorticotropin with arginine in residue positions 3 and 5. 下载免费PDF全文
E Jean-Baptiste M W Draper M A Rizack 《Proceedings of the National Academy of Sciences of the United States of America》1977,74(10):4329-4331
The maximal steroidogenic response (Smax) to adrenocorticotropin (ACTH) is enhanced by the substitution of arginine in position 3. Though the Smax of adrenocorticotropin-(3-10)-octapeptide [ACTH-(3-10)] is only 20% of ACTH-(1-24) in isolated rabbit adrenal cells and 10% in rat cells, [Arg3]ACTH-(3-10) has an Smax comparable to that of the longer peptide. Activity determined from the midpoints of dose-response curves (A50), however, is several orders of magnitude less. The Smax of ACTH-(4-10) is not significantly different from that of the 3-10 analog. Substitution of arginine in the 5 position of ACTH-(4-10) decreases activity for rabbit cells, but does not affect activity for rat cells. The substitution of arginine in the 5 position of ACTH-(1-20) markedly decreases Smax in rabbit but not rat cells. The Smax of [Arg 3,5)]ACTH-(3-10), containing both substitutions, is greater than that of ACTH-(3-10), but much less than that of [Arg3]acth-(3-10) in both species studied. These findings contrast with those in the rabbit adipocyte, where both arginine-containing ACTH analogs have enhanced activity and the effects of both substitutions in a single peptide are additive. 相似文献
23.
T-cell origin of Lennert''s lymphoma 总被引:1,自引:0,他引:1
N. T. J. O''Connor A. C. Feller J. S. Wainscoat K. C. Gatter G. Pallesen H. Stein K. Lennert D. Y. Mason 《British journal of haematology》1986,64(3):521-528
The arrangement of the T-cell receptor and immunoglobulin genes has been analysed in five cases of Lennert's lymphoma. All cases showed rearrangement of the gene coding for the beta chain of the T-cell receptor and a germline configuration of the immunoglobulin genes. This provides strong evidence that Lennert's lymphoma is a T-cell lymphoma. 相似文献
24.
25.
Marine Mommert Magali Perret Matthew Hockin Sébastien Viel Alexandre Belot Jean-Christophe Richard Mehdi Mezidi Jean-Baptiste Fassier Etienne Javouhey ANTOINE Study Group COVID-SER Study Group COVID-HCL Study Group Andrew Hemmert François Mallet Sophie Trouillet-Assant Karen Brengel-Pesce 《European journal of immunology》2021,51(4):989-994
Low concentrations of type-I interferon (IFN) in blood seem to be associated with more severe forms of Coronavirus disease 2019 (COVID-19). However, following the type-I interferon response (IR) in early stage disease is a major challenge. We evaluated detection of a molecular interferon signature on a FilmArray® system, which includes PCR assays for four interferon stimulated genes. We analyzed three types of patient populations: (i) children admitted to a pediatric emergency unit for fever and suspected infection, (ii) ICU-admitted patients with severe COVID-19, and (iii) healthcare workers with mild COVID-19. The results were compared to the reference tools, that is, molecular signature assessed with Nanostring® and IFN-α2 quantification by SIMOA® (Single MOlecule Array). A strong correlation was observed between the IR measured by the FilmArray®, Nanostring®, and SIMOA® platforms (r-Spearman 0.996 and 0.838, respectively). The FilmArray® panel could be used in the COVID-19 pandemic to evaluate the IR in 45-min with 2 min hand-on-time at hospitalization and to monitor the IR in future clinical trials. 相似文献
26.
Benoit Peyronnet Emmanuel Oger Zineddine Khene Gregory Verhoest Romain Mathieu Mathieu Roumiguié Jean-Baptiste Beauval Benjamin Pradere Alexandra Masson-Lecomte Christophe Vaessen Hervé Baumert Jean-Christophe Bernhard Nicolas Doumerc Stéphane Droupy Franck Bruyere Alexandre De La Taille Morgan Roupret Karim Bensalah 《World journal of urology》2015,33(11):1815-1820
27.
P J Boyle R J Nagy A M O''Connor S F Kempers R A Yeo C Qualls 《Proceedings of the National Academy of Sciences of the United States of America》1994,91(20):9352-9356
Brain glucose metabolism is impaired during hypoglycemia, but, if sustained, brain metabolism reverts to normal in animal models--data in man are lacking. We tested the hypothesis that adaptations occur to allow maintenance of normal rates of brain glucose uptake (BGU) following recurrent hypoglycemia in man. Twelve normal humans were studied over 4 days. On the initial day, arterial plasma glucose concentrations were decreased from 4.72 to 2.50 mmol/liter in five 0.56 mmol/liter steps. Cerebral blood flow, brain arteriovenous glucose difference, BGU, and cognitive function were quantitated at each step. BGU was initially impaired at the 3.61 mmol/liter glucose step (P = 0.04) and was antedated by increments in epinephrine that began at 4.16 mmol/liter (P = 0.03). The onset of hypoglycemic symptoms occurred during the 3.61 mmol/liter glucose step (P = 0.02), whereas tests of cognitive function generally deteriorated at the 3.05 mmol/liter step (P < 0.05). During the next 56 hr, mean glucose concentrations were kept at 2.9 +/- 0.1 mmol/liter and reached normal only during meals. The stepped clamp protocol was repeated beginning at 4.16 mmol/liter on the last day. No decrement in BGU was observed at any step; cognitive function was preserved until significantly lower glucose concentrations on the final day relative to the first (P = 0.04). Subjects remained asymptomatic of hypoglycemia until they reached a glucose concentration of 2.50 mmol/liter (P < 0.001 vs. day 1), while initial increments in all counterregulatory hormones were forestalled to lower glucose steps than on day 1. Therefore, adaptations occur that allow normal BGU and cerebral function to be maintained during recurrent systemic hypoglycemia. Counterregulatory events that should result in symptoms of hypoglycemia and increments in endogenous glucose production are prevented until extremely subnormal glucose concentrations. 相似文献
28.
Rivoirard Romain Moncharmont Coralie Assouline Avi Auberdiac Pierre Mery Benoite Falk Alexander Tuan Annède Pierre Trone Jane-Chloé Guy Jean-Baptiste Vial Nicolas Fournel Pierre Merrouche Yacine Chargari Cyrus Magné Nicolas 《European archives of oto-rhino-laryngology》2015,272(3):719-725
European Archives of Oto-Rhino-Laryngology - In the field of radiotherapy, there is very little scientific data on the management of nonagenarians, especially in patients aged 90 years or... 相似文献
29.
Thierry Boulain Julie Boisrame-Helms Stephan Ehrmann Jean-Baptiste Lascarrou Adrien Bouglé Arnaud Chiche Karim Lakhal Stéphane Gaudry Sébastien Perbet Arnaud Desachy Séverin Cabasson Isabelle Geneau Patricia Courouble Noémie Clavieras Pablo L. Massanet Frédéric Bellec Yoan Falquet François Réminiac Philippe Vignon Pierre-François Dequin Ferhat Meziani 《Intensive care medicine》2015,41(2):248-256
30.