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排序方式: 共有193条查询结果,搜索用时 15 毫秒
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153.
Jayasree Hansda Joydeb Roychowdhury 《Journal of obstetrics and gynaecology of India》2012,62(5):536-540
Objectives
Recently, it has been found that women who have thrombophilia have increased risk of fetal loss. This study was designed to corroborate the association of elevated factor VIII level, protein C and protein S deficiencies, and the presence of LAC in women with recurrent pregnancy loss.Materials and Methods
53 patients with history of two or more pregnancy losses and 47 healthy age-matched subjects with no history of pregnancy loss and who have delivered at least one term infant without any complication were enrolled into the study.Results
Thrombophilic defect was present in 64.15 % of patients of study group. Protein S deficiency (50.94 %) was the most common thrombophilic defect observed. Spontaneous abortion (SA), preterm birth (PTB), and intrauterine growth retardation (IUGR) were the most important pregnancy complications observed. The strongest associations of pregnancy complications were observed with protein S deficiency (87.5 %) and with elevated factor VIII (66.66 %) level.Conclusion
This study observed strong association of thrombophilia with unexplained recurrent pregnancy loss. 相似文献154.
155.
D. Ghosh Latika Dhawan P. G. L. Lalitkumar Viviana Wong J. F. Rosario A. G. Hendrickx B. L. Lasley J. W. Overstreet Jayasree Sengupta 《Contraception》2001,63(6):335-342
Intravaginal administration of an anti-microbial agent, (Ala8,13,18)-magainin II amide, during blastocyst implantation inhibits pregnancy establishment in a dose-related manner in the rhesus monkey (Macaca mulatta). In the present study, mated female rhesus monkeys were vaginally inserted with tampons containing vehicle (Group 1; N = 5) and test agent (magainin, 0.5 mg/animal; Group 2; N = 6) on cycle day 20. Endometrial tissue samples were collected on Cycle Day 24 from all monkeys and processed for morphometric and ultrastructural analysis. Concentrations of estradiol-17β, progesterone, and chorionic gonadotrophin in peripheral circulation were determined, which revealed that two monkeys in Group 1 were pregnant while no animals were pregnant in Group 2. Endometrial morphology, however, revealed histologic evidence of pregnancy in three out of the six magainin-treated animals. It appears that intra-vaginal administration of magainin II amide had a marginal effect on the implantation stage endometrium and the initiation of the implantation process in the rhesus monkey. 相似文献
156.
157.
Pillai GS Kumar A Radhakrishnan N Maniyelil J Shafi T Dinesh KR Karim S 《The American journal of tropical medicine and hygiene》2012,86(4):620-623
Intraocular gnathostomiasis is a rare parasitic infection caused by the third-stage larvae of spiruroid nematode Gnanthostoma spp. seen mostly in tropical and subtropical regions. It is a food-borne zoonosis caused by ingestion of raw or undercooked freshwater fish, amphibians, reptiles, birds, and mammals, all of which are known to harbor advanced third-stage larvae of Gnanthostoma spp. To date, 74 cases of intraocular gnathostomiasis have been reported from 12 different countries. Only four countries have reported more than 10 cases each, and India shares the rare distinction of being one of them, with 14 cases. Surprisingly, not a single case of cutaneous gnanthostomiasis has ever been reported from India. We present one such case of intraocular gnathostomiasis in a 41-year-old male who presented with an actively motile worm attached to the iris, and we review the pertinent literature of all such cases reported from India. 相似文献
158.
Rangaraj M. Rangayyan Shantanu Banik Jayasree Chakraborty Sudipta Mukhopadhyay J. E. Leo Desautels 《International journal of computer assisted radiology and surgery》2013,8(4):527-545
Purpose We propose a method for the detection of architectural distortion in prior mammograms of interval-cancer cases based on the expected orientation of breast tissue patterns in mammograms. Methods The expected orientation of the breast tissue at each pixel was derived by using automatically detected landmarks including the breast boundary, the nipple, and the pectoral muscle (in mediolateral-oblique views). We hypothesize that the presence of architectural distortion changes the normal expected orientation of breast tissue patterns in a mammographic image. The angular deviation of the oriented structures in a given mammogram as compared to the expected orientation was analyzed to detect potential sites of architectural distortion using a measure of divergence of oriented patterns. Each potential site of architectural distortion was then characterized using measures of spicularity and angular dispersion specifically designed to represent spiculating patterns. The novel features for the characterization of spiculating patterns include an index of divergence of spicules computed from the intensity image and Gabor magnitude response using the Gabor angle response; radially weighted difference and angle-weighted difference (AWD) measures of the intensity, Gabor magnitude, and Gabor angle response; and AWD in the entropy of spicules computed from the intensity, Gabor magnitude, and Gabor angle response. Results Using the newly proposed features with a database of 106 prior mammograms of 56 interval-cancer cases and 52 mammograms of 13 normal cases, through feature selection and pattern classification with an artificial neural network, an area under the receiver operating characteristic curve of 0.75 was obtained. Free-response receiver operating characteristic analysis indicated a sensitivity of 0.80 at 5.3 false positives (FPs) per patient. Combining the features proposed in the present paper with others described in our previous works led to significant improvement with a sensitivity of 0.80 at 3.7 FPs per patient. Conclusion The proposed methods can detect architectural distortion in prior mammograms taken 15 months (on the average) before clinical diagnosis of breast cancer, but the FP rate needs to be reduced. 相似文献
159.
Objectives
The study aims to evaluate the difference in diffusion properties between high grade glioma and low grade glioma by measuring the total magnitude of diffusion tensor (L), and its isotropic (p) and anisotropic (q) components.Methods
The diffusion tensor parameters p, q, L and FA from the tumor area, adjacent area to the tumor and corresponding contra lateral normal area of 30 high grade glioma and 49 low grade glioma were calculated. Chi square analysis was done to find the changes in age and sex. One Way ANOVA was performed to compare the mean and ROC curve analysis to confirm the discriminative sensitivity.Results
Major variation in the mean values of p, L and FA was observed in different brain areas considered. Variation in the p and L values between low grade and high grade glioma were statistically significant (p < 0.001) and their ROC curve analysis yielded 93.9% and 91.8% sensitivity and 53.3% specificity respectively.Conclusion
Measurement of the isotropic component p and the total value of diffusion tensor L can be effectively correlated with different grades of glioma and can be used to study the diffusion properties of tumor affected brain. 相似文献160.
Yemi Aina Jayasree Nandagopol Henry A. Nasrallah 《Current Psychosis and Therapeutics Reports》2004,2(2):78-83
Schizophrenia and its treatment are associated with several endocrinopathies, some well studied but others not. Among the
most extensively investigated endocrine functions has been the hyperprolactinemia associated with the dopamine receptor antagonism
exerted by antipsychotic agents. More recently, diabetes and insulin regulation has been the focus of intensified investigation
due the potentially serious metabolic effects. Some evidence points to higher frequency of diabetes in schizophrenia prior
to treatment, whereas an expanding body of evidence suggests an increase in diabetes following treatment with some but not
all second-generation antipsychotics. This article reviews the recent developments in the treatment-emergent endocrine abnormalities
in schizophrenia and points to relevant clinical implications for the treatment of schizophrenia. 相似文献