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991.
Hard metal lung disease is an unusual disease which can occur in individuals exposed to hard metals. Clinically, the condition resembles hypersensitivity pneumonitis depending mainly on individual susceptibility, which eventually progresses to pulmonary fibrosis. We present two patients with pulmonary fibrosis, who were actually diagnosed after an exhaustive anamnesis and examination of the tissue by scanning microscope to discard hard metals. The evaluation of wedge biopsies by scanning electronic microscope can be very helpful in those cases without a specific diagnosis. 相似文献
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Laurent Frenzel Rose-Marie Javier Francoise Eichler Goerg Zollner Jean Sibilia 《Joint, bone, spine : revue du rhumatisme》2010,77(2):171-173
Bone metastases are usually seen on imaging studies as lytic lesions and less often as sclerotic or mixed lesions. We report an exceedingly unusual case of breast cancer identified after magnetic resonance imaging showed bone metastases with fluid-fluid levels in the spine and sacrum. Bone images containing fluid-fluid levels are usually solitary abnormalities produced by aneurismal bone cysts. The fluid-fluid level is due to bleeding within the tumor followed by layering of the blood components based on density differences. Only two other cases of bone metastases with multiple fluid-fluid levels have been reported. Although fluid-fluid levels are exceedingly rare, clinicians should be aware that they might indicate a malignancy, particularly when they are multiple. 相似文献
995.
K.G. Borelli D.C. Blanchard L.K. Javier E.B. Defensor M.L. Brandão R.J. Blanchard 《Neuroscience》2009
Mice show urinary scent marking behavior as a form of social communication. Marking to a conspecific stimulus mouse or odor varies with stimulus familiarity, indicating discrimination of novel and familiar animals. This study investigated Fos immunoreactivity in inbred C57BL/6J (C57) males following scent marking behavior in response to detection of a social stimulus, or discrimination between a familiar and an unfamiliar conspecific. In Experiment 1 C57 mice were exposed for four daily trials to an empty chamber; on a test day they were exposed to the same chamber or to a male CD-1 mouse in that chamber. Increased scent marking to the CD-1 mouse was associated with increased Fos-immunoreactive cells in the basolateral amygdala, medial amygdala, and dorsal and ventral premammillary nuclei. In Experiment 2 C57 mice were habituated to a CD-1 male for 4 consecutive days and, on the 5th day, exposed to the same CD-1 male, or to a novel CD-1 male. Mice exposed to a novel CD-1 displayed a significant increase in scent marking compared to their last exposure to the familiar stimulus, indicating discrimination of the novelty of this social stimulus. Marking to the novel stimulus was associated with enhanced activation of several telencephalic, as well as hypothalamic and midbrain, structures in which activation had not been seen in the detection paradigm (Experiment 1). These included medial prefrontal and piriform cortices, and lateral septum; the paraventricular nuclei, ventromedial nuclei, and lateral area of the hypothalamus, and the ventrolateral column of the periaqueductal gray. These data suggest that a circumscribed group of structures largely concerned with olfaction is involved in detection of a conspecific olfactory stimulus, whereas discrimination of a novel vs. a familiar conspecific stimulus engages a wider range of forebrain structures encompassing higher-order processes and potentially providing an interface between cognitions and emotions. 相似文献
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Joan Manel Gasent Blesa Vicente Alberola Candel Javier Rius Jordà 《Progresos de Obstetricia y Ginecología》2009
Ovarian cancer is often diagnosed in the advanced stages. Primary cytoreduction still retains its central prognostic value. We have witnessed a general in treatment results since the appearance of the taxanes and the development of the intraperitoneal therapies. However, the latter has not been incorporated into routine clinical practice, given the difficulties it poses. After adjuvant chemotherapy the majority of our patients will recur. If we could identify high risk patients, we could study and develop better strategies for these patients. 相似文献
998.
Javier Gualis Ph.D. Mario Castaño Ph.D. Jesús Gómez‐Plana M.D. Carlos Martín M.D. David Alonso M.D. 《Journal of cardiac surgery》2010,25(6):656-658
Abstract Cardiac fibromas are rare benign tumors predominantly diagnosed in children and teenagers. We report a 57‐year‐old male patient with class II dyspnea and angina. During electrocardiographic assessment, recurrent ventricular tachycardia was present and magnetic resonance imaging revealed a giant (12.5 × 5 × 4 cm) intramural left ventricular tumor compatible with cardiac fibroma. After surgical biopsy and histological confirmation, open‐heart surgical resection was successfully performed. After nine months of follow up, the patient remains asymptomatic without evidence of ventricular tachycardia. (J Card Surg 2010;25:656‐658) 相似文献
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