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排序方式: 共有1598条查询结果,搜索用时 9 毫秒
111.
Antonio Juli Francisco Blanco Benjamín Fernndez‐Gutierrez Antonio Gonzlez Juan D. Caete Joan Maym Mercedes Alperi‐Lpez Alex Oliv Hctor Corominas Víctor Martínez‐Taboada Isidoro Gonzlez-lvaro Antonio Fernandez‐Nebro Alba Erra Simn Snchez‐Fernndez Arnald Alonso María Lpez‐Lasanta Raül Tortosa Laia Cod Josep Lluis Gelpi Andrs C. García‐Montero Jaume Bertranpetit Devin Absher Richard M. Myers Jesús Tornero Sara Marsal 《Arthritis \u0026amp; Rheumatology》2016,68(6):1384-1391
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Elizondo E Sala S Imbuluzqueta E González D Blanco-Prieto MJ Gamazo C Ventosa N Veciana J 《Pharmaceutical research》2011,28(2):309-321
Purpose
To investigate, for the first time, the viability of compressed antisolvent methodologies for the preparation of drug-loaded particles of the biodegradable and bioadhesive polymer poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA), utilizing gentamicin (Gm) as a model drug. 相似文献116.
Gonzalez-Pinto A Vieta E Reed C Novick D Barraco A Aguado J Haro JM 《Journal of affective disorders》2011,131(1-3):320-329
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118.
Giordani RB Junior CO de Andrade JP Bastida J Zuanazzi JA Tasca T de Almeida MV 《Chemical biology & drug design》2012,80(1):129-133
Six lycorine derivatives were prepared, characterized, and evaluated for their in vitro anti‐Trichomonas vaginalis activity. Compounds bearing an acetyl ( 2 ), lauroyl ( 3 ), benzoyl ( 4 and 5 ), and p‐nitrobenzoyl ( 6 and 7 ) groups were synthesized. The best activity was achieved with lycorine esterified at C‐2 position with lauroyl group. Preliminary structure–activity relationship points that unprotected OH group at C‐1 and C‐2 is not necessary to the antiparasitic activity, and none of the derivative was less active than lycorine. The lycorine structural requisites required to kill this amitochondriate cell seem to be different in comparison with the derivatives most active against other parasites and tumor cell lines, both mitochondriated cells. This result is an important contribution with our ongoing studies regarding the mechanism of action of the Amaryllidaceae alkaloids on T. vaginalis cell death opening a new perspective to optimize this innovative pharmacological potential. 相似文献
119.
Fernández S Mosquera JL Alaña L Sanchez-Pla A Morote J Ramón Y Cajal S Reventós J de Torres I Paciucci R 《Virchows Archiv : an international journal of pathology》2011,458(3):323-330
The prostate tumor overexpressed-1 (PTOV1) protein was first described overexpressed in prostate cancer but not detected in
normal prostate. PTOV1 expression is associated to increased cancer proliferation in vivo and in vitro. In prostate biopsy,
PTOV1 detection is helpful in the early diagnosis of cancer. The purpose of this study was to analyze the relevance of PTOV1
expression to identify aggressive tumors derived from 12 different histological tissues. Tissue microarrays (TMAs) containing
182 biopsy samples, including 168 human tumors, were analyzed for PTOV1 and Ki67 expression by immunohistochemistry. Tumors
of low and high histological grade were selected from lung, breast, endometrium, pancreas liver, skin, ovary, colon, stomach,
kidney, bladder, and cerebral gliomas. One TMA with representative tissues without cancer (14 samples) was used as control.
PTOV1 expression was analyzed semiquantitatively for the intensity and percentage of positive cells. Ki67 was evaluated for
tumors proliferative index. Results show that PTOV1 was expressed in over 95% of tumors examined. Its expression was significantly
associated to high-grade tumors (p = 0.014). This association was most significant in urothelial bladder carcinomas (p = 0.026). Overall, the expression of Ki67 was associated to high-grade tumors, and it was significant in several tumor types.
PTOV1 and Ki67 were significantly co-overexpressed in all tumors (p = 0.001), and this association was significant in clear cell renal carcinoma (p = 0.005). In conclusion, PTOV1 expression is associated to more aggressive human carcinomas and more significantly to bladder
carcinomas suggesting that this protein is a potential new marker of aggressive disease in the latter tumors. 相似文献