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31.
Zuzana Kubová Miroslav Kuba Jaroslav Hubacek František VíT 《Documenta ophthalmologica. Advances in ophthalmology》1990,75(1):67-72
In 80 subjects the dependence of movement-onset visual evoked potentials on some measures of stimulation was examined, and these responses were compared with pattern-reversal visual evoked potentials to verify the effectiveness of pattern movement application for visual evoked potential acquisition. Horizontally moving vertical gratings were generated on a television screen. The typical movement-onset reactions were characterized by one marked negative peak only, with a peak time between 140 and 200ms. In all subjects the sufficient stimulus duration for acquisition of movement-onset-related visual evoked potentials was 100ms; in some cases it was only 20ms. Higher velocity (5.6°/s) produced higher amplitudes of movement-onset visual evoked potentials than did the lower velocity (2.8°/s). In 80% of subjects, the more distinct reactions were found in the leads from lateral occipital areas (in 60% from the right hemisphere), with no correlation to handedness of subjects. Unlike pattern-reversal visual evoked potentials, the movement-onset responses tended to be larger to extramacular stimulation (annular target of 5°–9°) than to macular stimulation (circular target of 5° diameter).Abbreviation PREP
pattern-reversal visual evoked potentials 相似文献
32.
Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate. 总被引:7,自引:0,他引:7
Jean-Pierre J Issa Vazganush Gharibyan Jorge Cortes Jaroslav Jelinek Gail Morris Srdan Verstovsek Moshe Talpaz Guillermo Garcia-Manero Hagop M Kantarjian 《Journal of clinical oncology》2005,23(17):3948-3956
PURPOSE: To determine the activity of decitabine, a DNA methylation inhibitor, in imatinib-refractory or intolerant chronic myelogenous leukemia. MATERIALS AND METHODS: Thirty-five patients were enrolled in this phase II study (12 in chronic phase, 17 in accelerated phase, and six in blastic phase). Decitabine was administered at 15 mg/m2 intravenously over 1 hour daily, 5 days a week for 2 weeks. DNA methylation was measured using a LINE1 bisulfite/pyrosequencing assay. RESULTS: Complete hematologic responses were seen in 12 patients (34%) and partial hematologic responses in seven patients (20%), for an overall hematologic response rate of 54% (83% in chronic phase, 41% in accelerated phase, and 34% in blastic phase). Major cytogenetic responses were observed in six patients (17%), and minor cytogenetic responses were seen in 10 patients (29%) for an overall cytogenetic response rate of 46%. Median response duration was 3.5 months (range, 2 to 13+ months). Myelosuppression was the major adverse effect, with neutropenic fever in 28 (23%) of 124 courses of therapy. LINE1 methylation decreased from 71.3% +/- 1.4% (mean +/- standard error of the mean) to 60.7% +/- 1.4% after 1 week, 50.9% +/- 2.4% after 2 weeks, and returned to 66.5% +/- 2.7% at recovery of counts (median, 46 days). LINE1 methylation at the end of week 1 did not correlate with subsequent responses. However, at day 12, the absolute decrease in methylation was 14.5% +/- 3.0% versus 26.8% +/- 2.7% in responders versus nonresponders (P = .007). CONCLUSION: Decitabine induces hypomethylation and has clinical activity in imatinib refractory chronic myelogenous leukemia. We hypothesize that the inverse correlation between hypomethylation 2 weeks after therapy and response is due to a cell death mechanism of response, whereby resistant cells can withstand more hypomethylation. 相似文献
33.
Sanguinarine and chelerythrine: assessment of safety on pigs in ninety days feeding experiment. 总被引:4,自引:0,他引:4
Pavel Kosina Daniela Walterová Jitka Ulrichová Václav Lichnovsky Marie Stiborová Helena Rydlová Jaroslav Vicar Vladimír Krecman Michael J Brabec Vilím Simánek 《Food and chemical toxicology》2004,42(1):85-91
Sanguinaria canadesis, Chelidonium majus and Macleya cordata have been used for centuries as alternative medicines. Currently the extracts from these medicinal plants are components of veterinary and human phytopreparations, and of oral-hygiene agents. Sanguinarine and chelerythrine (SA/CHE) are biologically active components of these extracts. They display distinct antibacterial and anti-inflammatory properties, but, on the other hand, they have been reported as having adverse effects - genotoxicity and hepatotoxicity. This paper is aimed at evaluation of the effects of daily administration of the extract from Macleya cordata (2 mg and 100 mg in 1 kg feed, sanguinarine:chelerythrine 3:1) in the diet on the health status of swine. After 90-day administration, alkaloids were retained to a different extent in tissues. The highest SA/CHE retention was detected in the gingiva (0.55 microg/g) and liver (0.15 microg/g), no SA/CHE were detected in muscles. Plasma SA levels attained 0.11 microg/ml. Treated animals did not display any results of hematological, biochemical or histological assay different from controls. A (32)P-postlabeling assay proved that no DNA-adducts with SA/CHE were detected in pig livers. We did not observe any symptom linked to epidemic dropsy syndrome often attributed to sanguinarine. In conclusion, an average daily oral dose of alkaloids up to 5 mg per 1 kg animal body weight proved to be safe. 相似文献
34.
35.
A patient is reported with a typical Down syndrome phenotype, caused by patrial trisomy of chromosome 21. Based on the present case and data from the literature, it is suggested that the Down phenotype is due to the trisomy of the distal portion of the band (q22) of chromosome 21. 相似文献
36.
Jaroslav KŘíŽenecký 《Pflügers Archiv : European journal of physiology》1926,211(1):663-665
Ohne Zusammenfassung 相似文献
37.
C. Leiner Wilhelm Balban Edgar Braendle Alfred Kraus F. Münchheimer Fritz Juliusberg J. Ullmann Jaroslav Odstrčil Weiler Alfred Roth R. Volk Viktor Bandler 《Archives of dermatological research》1912,115(1):139-148
Ohne Zusammenfassung 相似文献
38.
39.
Prospective study of signalling pathways in myeloma bone disease with regard to activity of the disease,extent of skeletal involvement and correlation to bone turnover markers 下载免费PDF全文
40.
Differential expression of homologous recombination DNA repair genes in the early and advanced stages of myelodysplastic syndrome 下载免费PDF全文