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Saenz AJ Lee-Lewandrowski E Wood MJ Neilan TG Siegel AJ Januzzi JL Lewandrowski KB 《American journal of clinical pathology》2006,126(2):185-189
We report changes in cardiac troponin-T (TnT) and a new plasma stroke biomarker panel (D-dimer, B-natriuretic peptide [BNP], matrix metalloproteinase-9 [MMP-9], S-100 b, Biosite Diagnostics, San Diego, CA) in 30 nonprofessional marathon runners before and immediately after the 2005 Boston Marathon. Following competition, there was a statistically significant increase in MMP-9 (P < .001) and D dimer (P < .001). Nonsignificant changes in S-100 b and BNP were observed. Premarathon and postmarathon values for a multimarker stroke index increased from 0.97 (normal) to 3.5 (low risk or more; P < .001). Two subjects had index values more than the high-risk cutoff value. Mean TnT premarathon and postmarathon levels increased (from <0.01 to 0.03 ng/mL; P < .0001). After the marathon, with a cutoff value of 0.05 ng/mL, 7 runners (23%) had values above the manufacturer's recommended cutoff for myocardial damage. Although biochemical evidence of myocardial damage following strenuous exercise may reflect myocardial stunning or subclinical ischemia, the changes in the stroke index and values for individual stroke markers may reflect a systemic inflammatory response to exertional rhabdomyolysis which is common, but the possibility of subclinical central nervous system damage cannot be excluded. 相似文献
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2018 ACC/HRS/NASCI/SCAI/SCCT Expert Consensus Document on Optimal Use of Ionizing Radiation in Cardiovascular Imaging: Best Practices for Safety and Effectiveness 下载免费PDF全文
Writing Committee Members John W. Hirshfeld MD FACC FSCAI Chair Jr. Victor A. Ferrari MD FACC Co‐Chair Lisa Bergersen MD MPH FACC Andrew J. Einstein MD PhD FACC Mark J. Eisenberg MD MPH FACC Mark A. Fogel MD FACC Thomas C. Gerber MD FACC Warren K. Laskey MD MPH FACC FSCAI Marian C. Limacher MD FACC Daniel A. Pryma MD Arthur E. Stillman MD PhD FNASCI Suma A. Thomas MD MBA FACC Thomas T. Tsai MD MSc FACC Louis K. Wagner PhD L. Samuel Wann MD MACC James L. Januzzi MD FACC Jr Luis C. Afonso MBBS FACC Brendan Everett MD FACC Adrian F. Hernandez MD MHS FACC William Hucker MD PhD Hani Jneid MD FACC Dharam Kumbhani MD SM FACC Joseph Edward Marine MD FACC Pamela Bowe Morris MD FACC Robert N. Piana MD FACC Karol E. Watson MD FACC Barbara S. Wiggins PharmD AACC 《Catheterization and cardiovascular interventions》2018,92(2):E35-E97
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Sakhuja R Chen AA Anwaruddin S Baggish AL Januzzi JL 《The American journal of cardiology》2005,96(2):263-266
The combination of elevated amino-terminal pro-brain natriuretic peptide levels and wide QRS duration was highly sensitive and specific for the prediction of impaired left ventricular systolic function among a group of patients presenting with dyspnea to the emergency department. This strategy can be used to predict depressed function and target more formal evaluation with echocardiography in patients with dyspnea. 相似文献
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Comparison of Risk Prediction With the CKD‐EPI and MDRD Equations in Non–ST‐Segment Elevation Acute Coronary Syndrome 下载免费PDF全文