全文获取类型
收费全文 | 260篇 |
免费 | 12篇 |
专业分类
基础医学 | 18篇 |
口腔科学 | 2篇 |
临床医学 | 44篇 |
内科学 | 191篇 |
神经病学 | 5篇 |
特种医学 | 2篇 |
外科学 | 6篇 |
综合类 | 1篇 |
预防医学 | 2篇 |
药学 | 1篇 |
出版年
2024年 | 1篇 |
2023年 | 4篇 |
2021年 | 8篇 |
2020年 | 3篇 |
2019年 | 18篇 |
2018年 | 15篇 |
2017年 | 4篇 |
2016年 | 2篇 |
2015年 | 6篇 |
2014年 | 11篇 |
2013年 | 13篇 |
2012年 | 27篇 |
2011年 | 21篇 |
2010年 | 14篇 |
2009年 | 7篇 |
2008年 | 26篇 |
2007年 | 18篇 |
2006年 | 31篇 |
2005年 | 9篇 |
2004年 | 11篇 |
2003年 | 5篇 |
2002年 | 8篇 |
2001年 | 4篇 |
2000年 | 4篇 |
1999年 | 1篇 |
1987年 | 1篇 |
排序方式: 共有272条查询结果,搜索用时 515 毫秒
71.
72.
Manzano-Fernández S Pastor-Pérez FJ Barquero-Pérez Ó Pascual-Figal DA Goya-Esteban R Rojo-Álvarez JL Caamaño-Fernández A Martínez Martínez-Espejo MD Januzzi JL Valdés M García-Alberola A 《Journal of cardiac failure》2011,17(9):735-741
Background
Heart rate turbulence (HRT) is associated with risk in chronic heart failure (CHF). The objective of this study was to assess the short-term variability of HRT and to compare the diagnostic yield of 7-day (7DH) versus 24-hour (1DH) Holter monitoring for calculating HRT in a CHF population.Methods and Results
Forty-nine consecutive patients with CHF were studied. At inclusion, 7DH was performed to evaluate the variability of HRT parameters. For categorized analyses, turbulence onset (TO) ≥0% and turbulence slope (TS) ≤2.5 ms/RR were defined as abnormal, and patients were classified into subgroups based on the number of abnormal HRT parameters.The cumulative percentage of patients with calculable HRT increased from 69.4% with 1DH to 93.9% with 7DH. The intraclass correlation coefficients across the 7-day monitoring were 0.81 (95% confidence interval [CI] 0.70–0.89) for TO and 0.90 (95% CI 0.84–0.95) for TS. When comparing 2 randomly selected days, TO and TS values were similar (P > .1) and showed a strong correlation (TO: r = 0.79; TS: r = 0.84: P < .001). Bland-Altman plots showed a mean difference of 0.31% (95% CI −0.07 to 0.70) for TO and 0.44 ms/RR (95% CI −1.37 to 0.48) for TS. In contrast, categorized analyses showed that up to 16% of patients changed their HRT subgroup score from day 1 to day 2 of comparison.Conclusions
In this population, 7DH significantly increased the percentage of patients with calculable HRT parameters. The short-term variability of the quantitative HRT values was good, but when patients were categorized into the established HRT subgroups, the concordance was suboptimal. 相似文献73.
Hanumantha R. Jogu Sameer Arora Muthiah Vaduganathan Arman Qamar Ambarish Pandey Parag A. Chevli Tusharkumar H. Pansuriya Muhammad I. Ahmad Abhishek Dutta Padageshwar R. Sunkara Waqas Qureshi Sujethra Vasu Bharathi Upadhya Deepak L. Bhatt James L. Januzzi David Herrington 《Clinical cardiology》2019,42(6):592-604
74.
James L. Januzzi Simon A. Mahler Robert H. Christenson Jennifer Rymer L. Kristin Newby Richard Body David A. Morrow Allan S. Jaffe 《Journal of the American College of Cardiology》2019,73(9):1059-1077
High-sensitivity cardiac troponin (hs-cTn) I or T methods have been in use in certain regions for years but are now increasingly globally adopted, including in the United States. Accordingly, inevitable challenges are created for institutions transitioning from conventional cardiac troponin (cTn) assays. hs-cTn assays have higher analytic precision at lower concentrations, yielding greater clinical sensitivity for myocardial injury and allowing accurate recognition of small changes in troponin concentration (rise or fall) within a short time frame. Although much of the knowledge regarding troponin biology that was applicable with older troponin assays still holds true, considerable education regarding the differences between conventional cTn and hs-cTn is needed before medical systems convert to the newer methods. This includes a basic understanding of how hs-cTn testing differs from conventional cTn testing and how it is best deployed in different settings, such as the emergency department and inpatient services. This Expert Panel will review important concepts for institutional transition to hs-cTn methodology, providing recommendations useful for education before implementation. 相似文献
75.
76.
S. Celik E. Giannitsis K. C. Wollert K. Schw?bel D. Lossnitzer T. Hilbel S. Lehrke D. Zdunek A. Hess J. L. Januzzi H. A. Katus 《Clinical research in cardiology》2011,100(12):1077-1085
Objective
A recently developed immunoassay for high-sensitivity measurement of cardiac troponin T (hsTnT) allows measurement at the 99th percentile for a normal population with an assay imprecision <10%. It is unclear whether such a low cutpoint (14?ng/L) is helpful for long-term risk stratification of patients with an acute coronary syndrome (ACS) undergoing routine early invasive strategy.Patients and main outcome measures
Consecutive patients with ACS admitted to a chest pain unit were studied. The usefulness of hsTnT for early diagnosis of myocardial infarction (MI) and prediction of all-cause death or death/MI over a median of 271?days following presentation was compared against the fourth generation cTnT at the 99th percentile cutpoint.Results
Of 1,384 patients with ACS enrolled, 47.8% had non-ST-segment elevation MI (NSTEMI), 26.4% unstable angina, 21.8% STEMI and 4% had non-ACS. Adjusted risk for all-cause death [adjusted HR 8.26 (95%CI: 1.13?C66.33), p?=?0.038] and death/MI [adjusted HR 2.71 (95% CI: 1.15?C6.38), p?=?0.023] were significantly higher with hsTnT above the 99th percentile. In particular, among patients with a standard fourth generation cTnT result below the 99th percentile cutoff (0.01?ng/mL), hsTnT improved risk assessment. Mortality risk associated with an elevated hsTnT was present across the spectrum of ACS, as well as in conditions with hsTnT elevations not related to ACS.Conclusion
hsTnT at the 99th percentile cutoff is useful for the diagnostic evaluation of patients with ACS, and provides strong and independent predictive power for adverse long-term outcomes even after early invasive strategy. 相似文献77.
Karakas M Januzzi JL Meyer J Lee H Schlett CL Truong QA Rottbauer W Bamberg F Dasdemir S Hoffmann U Koenig W 《Clinical chemistry》2011,57(8):1137-1145
78.
79.
80.