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21.
An interesting case of wide QRS tachycardia with right bundle branch block morphology: What is the mechanism? 下载免费PDF全文
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Narrow QRS tachycardia with apparent concentric atrial activation pattern: What is the mechanism? 下载免费PDF全文
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Monique Lhussier HND MSc PhD Simon Eaton BMedSci BMBS FRCP DM CertMEd Natalie Forster BA PGCert Mathew Thomas BA Sue Roberts MBBS MSc FRCP Susan M Carr BA MSc PhD 《Health expectations》2015,18(5):605-624
Objective
This article focuses on approaches within clinical practice that seek to actively involve patients with long‐term conditions (LTCs) and how professionals may understand and implement them. Personalized care planning is one such approach, but its current lack of conceptual clarity might have impeded its widespread implementation to date. A variety of overlapping concepts coexist in the literature, which have the potential to impair both clinical and research agendas. The aim of this article is therefore to explore the meaning of the concept of care planning in relation to other overlapping concepts and how this translates into clinical practice implementation.Methods
Searches were conducted in the Cochrane database for systematic reviews, CINHAL and MEDLINE. A staged approach to conducting the concept mapping was undertaken, by (i) an examination of the literature on care planning in LTCs; (ii) identification of related terms; (iii) locating reviews of those terms. Retrieved articles were subjected to a content analysis, which formed the basis of our concept maps. (iv) We then appraised these against knowledge and experience of the implementation of care planning in clinical practice.Results and Conclusions
Thirteen articles were retrieved, in which the core importance of patient‐centredness, shared decision making and self‐management was highlighted. Literature searches on these terms retrieved a further 24 articles. Our concept mapping exercise shows that whilst there are common themes across the concepts, the differences between them reflect the context and intended outcomes within clinical practice. We argue that this clarification exercise will allow for further development of both research and clinical implementation agendas. 相似文献25.
Identification of an oncogenic form of the thrombopoietin receptor MPL using retrovirus-mediated gene transfer 总被引:3,自引:3,他引:3
Onishi M; Mui AL; Morikawa Y; Cho L; Kinoshita S; Nolan GP; Gorman DM; Miyajima A; Kitamura T 《Blood》1996,88(4):1399-1406
Thrombopoietin and its receptor (MPL) are important regulators of megakaryopoiesis. We have identified an activating mutation of MPL using a combination of a retrovirus-mediated gene transfer and polymerase chain reaction-driven random mutagenesis. This point mutation causes a single amino acid substitution from Ser498 to Asn498 in the transmembrane region and abrogates factor-dependency of all interleukin-3-dependent cell lines tested. Murine interleukin-3- dependent Ba/F3 cells expressing the mutated but not the normal form of MPL were tumorigenic when transduced into syngeneic mice. Analysis of intracellular signaling pathways indicated that the mutant MPL protein constitutively activated two distinct signaling pathways, SHC-Raf-MAPK and JAK2-STAT3/STAT5. 相似文献
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DM Clarkson 《Journal of medical engineering & technology》2013,37(3):125-131
An overview is provided of the scope and application of IEC TR 60825-9 in determination of hazards of non coherent optical radiation sources. Specific areas reviewed in detail include those relating to hazards of ultraviolet radiation, retinal thermal hazard and blue light photochemical hazard. The effect of spectral temperature on relative risk relating to retinal thermal hazard and blue light photochemical hazard are outlined. Assessment of risk factors of these hazards was determined using a range of measurement devices including spectral radiometer, broad band power meter and a locally developed device for determination of pulse profile of pulsed light sources. 相似文献
28.
Recurrent Spontaneous Paresthesia in the Upper Limb Could Be Due to Migraine: A Case Series 下载免费PDF全文
Sanjay Prakash DM Chaturbhuj Rathore DM Prayag Makwana MD Mitali Rathod MD 《Headache》2015,55(8):1143-1147
Transient neurologic dysfunction is a characteristic feature of migraine. About 20% of migraineurs may experience various symptoms in the absence of any headache at one time or another. Visual auras are the most common auras of migraine, and migraine is considered as the most common cause of transient vision loss in young patients. Sensory auras are the second most common migrainous auras. However, the literature is silent for isolated sensory aura as a migraine equivalent. Herein we report 14 patients with recurrent episodic paresthesia in the limbs and other body parts. All patients fulfilled the diagnostic criteria of “typical aura without headache” of ICHD‐3β. All patients were subjected to various investigations to rule out secondary causes. Ten patients received antimigraine drugs and all showed a positive response to therapy. Recurrent spontaneous paresthesia is quite common in the general population and many patients remain undiagnosed. We speculate that a subset of patients might be related to migrainous sensory auras. 相似文献
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Erectile Impotence in Chronic Alcoholics 总被引:1,自引:0,他引:1
Edward T. H. Tan BSc PhD Ralph H. Johnson DM DSc FRCP David G. Lambie BSc PhD Mithra E. Vijayasenan MB BS FRANZCP Edwin A. Whiteside MB ChB 《Alcoholism, clinical and experimental research》1984,8(3):297-301
Erectile impotence is a common complaint in alcoholics, but its mechanism is unknown. We have studied nocturnal penile erection in 13 alcoholics who complained of impotence. Seven had normal erections and their impotence was therefore psychogenic. Six were found to have diminished or absent nocturnal erections. Plasma concentrations of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were elevated in this latter group, with the exception of one patient who had only raised FSH. They also had more evidence of neurological damage than the other seven alcoholics, and two had evidence of damage to the parasympathetic nervous system. Investigation of erection during sleep in alcoholic patients with impotence may be useful in differentiating clinically between patients with psychogenic causes and patients with organic causes of impotence. 相似文献