全文获取类型
收费全文 | 167篇 |
免费 | 11篇 |
专业分类
儿科学 | 2篇 |
妇产科学 | 6篇 |
基础医学 | 32篇 |
临床医学 | 20篇 |
内科学 | 48篇 |
皮肤病学 | 3篇 |
神经病学 | 9篇 |
特种医学 | 2篇 |
外科学 | 28篇 |
预防医学 | 12篇 |
眼科学 | 3篇 |
药学 | 9篇 |
中国医学 | 1篇 |
肿瘤学 | 3篇 |
出版年
2023年 | 2篇 |
2022年 | 4篇 |
2021年 | 8篇 |
2020年 | 2篇 |
2019年 | 4篇 |
2018年 | 10篇 |
2017年 | 2篇 |
2016年 | 3篇 |
2015年 | 6篇 |
2014年 | 5篇 |
2013年 | 10篇 |
2012年 | 8篇 |
2011年 | 8篇 |
2010年 | 8篇 |
2009年 | 6篇 |
2008年 | 8篇 |
2007年 | 18篇 |
2006年 | 4篇 |
2005年 | 7篇 |
2004年 | 5篇 |
2003年 | 7篇 |
2002年 | 6篇 |
2001年 | 4篇 |
2000年 | 4篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1990年 | 3篇 |
1989年 | 5篇 |
1987年 | 3篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 3篇 |
排序方式: 共有178条查询结果,搜索用时 15 毫秒
31.
32.
Wisniewska JM Rödl CB Kahnt AS Buscató E Ulrich S Tanrikulu Y Achenbach J Rörsch F Grösch S Schneider G Cinatl J Proschak E Steinhilber D Hofmann B 《Biochemical pharmacology》2012,83(2):228-240
5-Lipoxygenase (5-LO) is a crucial enzyme of the arachidonic acid (AA) cascade and catalyzes the formation of bioactive leukotrienes (LTs) which are involved in inflammatory diseases and allergic reactions. The pathophysiological effects of LTs are considered to be prevented by 5-LO inhibitors. In this study we present cyclohexyl-[6-methyl-2-(4-morpholin-4-yl-phenyl)-imidazo[1,2-a]pyridin-3-yl]-amine (EP6), a novel imidazo[1,2-a]pyridine based compound and its characterization in several in vitro assays. EP6 suppresses 5-LO activity in intact polymorphonuclear leukocytes with an IC(50) value of 0.16μM and exhibits full inhibitory potency in cell free assays (IC(50) value of 0.05μM for purified 5-LO). The efficacy of EP6 was not affected by the redox tone or the concentration of exogenous AA, characteristic drawbacks known for the class of nonredox-type 5-LO inhibitors. Furthermore, EP6 suppressed 5-LO activity independently of the cell stimulus or the activation pathway of 5-LO contrary to what is known for some nonredox-type inhibitors. Using molecular modeling and site-directed mutagenesis studies, we were able to derive a feasible binding region within the C2-like domain of 5-LO that can serve as a new starting point for optimization and development of new 5-LO inhibitors targeting this site. EP6 has promising effects on cell viability of tumor cells without mutagenic activity. Hence the drug may possess potential for intervention with inflammatory and allergic diseases and certain types of cancer including leukemia. 相似文献
33.
34.
35.
Luiz Schweitzer Alexandre Cunha Thiago Pereira Kerstin Mika Ana Maria Botelho do Rego Ana Maria Ferraria Heinz Kieburg Sven Geissler Eckart Uhlmann Janosch Schoon 《Materials》2020,13(23)
Loosening of orthodontic and orthopedic implants is a critical and common clinical problem. To minimize the numbers of revision surgeries due to peri-implant inflammation or insufficient osseointegration, developments of new implant manufacturing strategies are indicated. Ultrafast laser surface texturing is a promising contact-free technology to modify the physicochemical properties of surfaces toward an anti-infectious functionalization. This work aims to texture Ti6Al4V surfaces with ultraviolet (UV) and green (GR) radiation for the manufacturing of laser-induced periodic surface structures (LIPSS). The assessment of these surface modifications addresses key aspects of topography, morphology and chemical composition. Human primary mesenchymal stromal cells (hMSCs) were cultured on laser-textured and polished Ti6Al4V to characterize the surfaces in terms of their in vitro biocompatibility, cytotoxicity, and metal release. The outcomes of the in vitro experiment show the successful culture of hMSCs on textured Ti6Al4V surfaces developed within this work. Cells cultured on LIPSS surfaces were not compromised in terms of their viability if compared to polished surfaces. Yet, the hMSC culture on UV-LIPSS show significantly lower lactate dehydrogenase and titanium release into the supernatant compared to polished. Thus, the presented surface modification can be a promising approach for future applications in orthodontics and orthopedics. 相似文献
36.
Ellenberger C Schüppel KF Möhring M Reischauer A Alex M Czerny CP Fercho A Schoon HA 《Journal of comparative pathology》2005,132(1):101-105
Cowpox virus infection associated with a streptococcal septicaemia was diagnosed in a weak German Warmblood filly, born 29 days prematurely, and humanely destroyed on the sixth day of life. At necropsy, ulcerative lesions in the alimentary tract, colitis, polyarthritis and nephritis were observed. Transmission electron microscopical examination of specimens from ulcerative lesions revealed typical orthopox virions. Cowpox virus was unequivocally identified by virological and molecular-biological methods. 相似文献
37.
Christopher L Schlett Hinnerk Doll Janosch Dahmen Ole Polacsek Gero Federkeil Martin R Fischer Fabian Bamberg Martin Butzlaff 《BMC medical education》2010,10(1):1
Background
Problem-based Learning (PBL) has been suggested as a key educational method of knowledge acquisition to improve medical education. We sought to evaluate the differences in medical school education between graduates from PBL-based and conventional curricula and to what extent these curricula fit job requirements. 相似文献38.
39.
40.
Bo Jan Noordman Manon C W Spaander Roelf Valkema Bas P L Wijnhoven Mark I van Berge Henegouwen Joël Shapiro Katharina Biermann Ate van der Gaast Richard van Hillegersberg Maarten C C M Hulshof Kausilia K Krishnadath Sjoerd M Lagarde Grard A P Nieuwenhuijzen Liekele E Oostenbrug Peter D Siersema Erik J Schoon Meindert N Sosef Ewout W Steyerberg Heidi Rütten 《The lancet oncology》2018,19(7):965-974