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111.
Janice Munroe 《The Canadian journal of hospital pharmacy》2012,65(6):471-Dec;65(6):471
112.
Janice Munroe 《The Canadian journal of hospital pharmacy》2012,65(6):472-Dec;65(6):472
113.
Lengacher CA Reich RR Post-White J Moscoso M Shelton MM Barta M Le N Budhrani P 《Journal of behavioral medicine》2012,35(1):86-94
To investigate prevalence and severity of symptoms and symptom clustering in breast cancer survivors who attended MBSR(BC).
Women were randomly assigned into MBSR(BC) or Usual Care (UC). Eligible women were ≥ 21 years, had been diagnosed with breast
cancer and completed treatment within 18 months of enrollment. Symptoms and interference with daily living were measured pre-
and post-MBSR(BC) using the M.D. Anderson Symptom Inventory. Symptoms were reported as highly prevalent but severity was low.
Fatigue was the most frequently reported and severe symptom among groups. Symptoms clustered into 3 groups and improved in
both groups. At baseline, both MBSR(BC) and the control groups showed similar mean symptom severity and interference; however,
after the 6-week post-intervention, the MBSR(BC) group showed statistically-significant reduction for fatigue and disturbed
sleep (P < 0.01) and improved symptom interference items, compared to the control group. For the between-group comparisons, 11 of
13 symptoms and 5 of 6 interference items had lower means in the MBSR(BC) condition than the control condition. These results
suggest that MBSR(BC) modestly decreases fatigue and sleep disturbances, but has a greater effect on the degree to which symptoms
interfere with many facets of life. Although these results are preliminary, MBSR intervention post-treatment may effectively
reduce fatigue and related interference in QOL of breast cancer survivors. 相似文献
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JP Gouin CS Carter H Pournajafi-Nazarloo WB Malarkey TJ Loving J Stowell JK Kiecolt-Glaser 《Biological psychology》2012,91(2):270-274
The neuropeptide vasopressin has traditionally been associated with vasoconstriction and water reabsorption by the kidneys. However, data from experimental animal studies also implicate vasopressin in social bonding processes. Preliminary work suggests that vasopressin also plays a role in social behaviors in humans. The goal of this cross-sectional study was to evaluate associations among plasma vasopressin and self-reported interpersonal functioning in a sample of married couples. During a 24-h admission to a hospital-based research unit, 37 couples completed measures of interpersonal functioning and provided blood samples for neuropeptide analyses. Results showed that vasopressin was associated with markers of interpersonal functioning, but not with general psychological distress. Specifically, greater plasma vasopressin levels were related to a larger social network, fewer negative marital interactions, less attachment avoidance, more attachment security, and marginally greater spousal social support. These results indicate that vasopressin is likely implicated in different relationship maintenance processes in humans. 相似文献
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Pulmonary hypertension: Barrier or just a bump in the road in transplanting adults with congenital heart disease 下载免费PDF全文
Jonathan N. Menachem MD Edo Y. Birati MD Payman Zamani MD Anjali T. Owens MD Pavan Atluri MD Christian A. Bermudez MD David Drajpuch NP Stephanie Fuller MD Yuli Y. Kim MD Christopher E. Mascio MD Vikram Palanivel MD J. Eduardo Rame MD Joyce Wald DO Michael A. Acker MD Jeremy A. Mazurek MD 《Congenital heart disease》2018,13(4):492-498
118.
Luke A. Massey MRCP Caroline Micallef MD FRCR Dominic C. Paviour PhD Sean S. O'Sullivan PhD MRCPI Helen Ling BScMed BMBS MSc David R. Williams PhD Constantinos Kallis PhD Janice L. Holton PhD FRCPath Tamas Revesz MD FRCPath David J. Burn MD FRCP Tarek Yousry Dr med Habil FRCR Andrew J. Lees MD FRCP Nick C. Fox PhD FRCP Hans R. Jäger MD FRCR 《Movement disorders》2012,27(14):1754-1762
Conventional magnetic resonance imaging (cMRI) is often used to aid the diagnosis of progressive supranuclear palsy (PSP) and multiple system atrophy (MSA), but its ability to predict the histopathological diagnosis has not been systematically studied. cMRI from 48 neuropathologically confirmed cases, including PSP (n = 22), MSA (n = 13), Parkinson's disease (PD) (n = 7), and corticobasal degeneration (n = 6), and controls (n = 9) were assessed blinded to clinical details and systematically rated for reported abnormalities. Clinical diagnosis and macroscopic postmortem findings were retrospectively assessed. Radiological assessment of MRI was correct in 16 of 22 (72.7%) PSP cases and 10 of 13 (76.9%) MSA cases with substantial interrater agreement (Cohen's kappa 0.708; P < .001); no PSP case was misclassified as MSA or vice versa. MRI was less sensitive but more specific than clinical diagnosis in PSP and both more sensitive and specific than clinical diagnosis in MSA. The “hummingbird” and “morning glory” signs were highly specific for PSP, and “the middle cerebellar peduncle sign” and “hot cross bun” for MSA, but sensitivity was lower (up to 68.4%) and characteristic findings may not be present even at autopsy. cMRI, clinical diagnosis, and macroscopic examination at postmortem have similar sensitivity and specificity in predicting a neuropathological diagnosis. We have validated specific radiological signs in pathologically confirmed PSP and MSA. However, the low sensitivity of these and macroscopic findings at autopsy suggest a need for imaging techniques sensitive to microstructural abnormalities without regional atrophy. © 2012 Movement Disorder Society 相似文献
119.
Rong Liu Brian Hoffpauir Shannon D Chilewski Janice Gamberdella Uma Kavita Jia Duo Carol Gleason Yan Zhang Renuka Pillutla Binodh DeSilva Lora Hamuro 《The AAPS journal》2017,19(1):82-91
The Gyrolab? xP is a microfluidic platform for conducting ligand binding assays (LBAs) and is recognized for its utility in discovery bioanalysis. However, few reports have focused on the technology for regulated bioanalysis. This technology has the advantage of low reagent consumption, low sample volume, and automated ligand binding methods. To improve bioanalysis testing timelines and increase the speed at which biotherapeutics are delivered to patients, we evaluated the technology for its potential to deliver high-quality data at reduced testing timelines for regulated bioanalysis. Six LBA methods were validated to support bioanalysis for GLP toxicokinetic or clinical pharmacokinetic studies. Validation, sample analysis, and method transfer are described. In total, approximately 4000 samples have been tested for regulated bioanalysis to support 6 GLP toxicology studies and approximately 1000 samples to support 2 clinical studies. Gyrolab? xP had high run pass rates (≥83%) and high incurred sample reanalysis (ISR) pass rates (>94%). The maximum total error observed across all QC levels for a given assay was <30% for all six LBAs. High instrument response precision (CV ≤5%) was observed across compact discs (CDs), and methods were validated to use a single standard curve across multiple CDs within a Gyrolab? xP run. Reduced bioanalysis timelines were achieved compared to standard manual plate-based methods, and methods were successfully transferred across testing labs, paving the way for this platform for use in late-stage clinical development. 相似文献
120.